Prof. Zhen Yuan
University of Macau, Macau, Macao
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Academic Career Length
24Years (2003-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications5 January 2022 in Journal of the American Chemical Society
Journal Article
LXLisi Xie
Lisi Xie
JLJie Li
Jie Li
GWGuohao Wang
Guohao Wang
WSWei Sang
Wei Sang
MXMengze Xu
Mengze Xu
Yunlu Dai +7
26 June 2017 in Nano Letters
Journal Article
KCKaiwen Chang
Kaiwen ChangZLZhihe Liu
Zhihe LiuXFXiaofeng Fang
Xiaofeng Fang
Haobin ChenXMXiaoju Men
Xiaoju Men
CWChangfeng Wu
Changfeng Wu +4
2 August 2022 in Nature Communications
Journal Article
Bacteria-based tumor therapy has recently attracted wide attentions due to its unique capability in targeting tumors and preferentially colonizing the core area of the tumor. Various therapeutic genes are also harbored into these engineering bacteria to enhance their anti-tumor efficacy. However, it is difficult to spatiotemporally control the expression of these inserted genes in the tumor site. Here, we engineer an ultrasound-responsive bacterium (URB) which can induce the expression of exogenous genes in an ultrasound-controllable manner. Owing to the advantage of ultrasound in tissue penetration, an acoustic remote control of bacterial gene expression can be realized by designing a temperature-actuated genetic switch. Cytokine interferon-γ (IFN-γ), an important immune regulatory molecule that plays a significant role in tumor immunotherapy, is used to test the system. Our results show that brief hyperthermia induced by focused ultrasound promotes the expression of IFN-γ gene, improving anti-tumor efficacy of URB in vitro and in vivo. Our study provides an alternative strategy for bacteria-mediated tumor immunotherapy.
25 October 2019 in Epidemiology and Psychiatric Sciences
Journal Article
MDMin Dong
Min Dong
LLLi LU
Li LULZLing Zhang
Ling Zhang
QZQinge Zhang
Qinge Zhang
GUGabor S. Ungvari
Gabor S. Ungvari
YXYu-Tao Xiang
Yu-Tao Xiang +4
Aims: Bipolar disorder (BD) is a severe psychiatric disorder associated with a high risk of suicide. This meta-analysis examined the prevalence of suicide attempts (SA) in patients with BD and its associated factors.Methods: A systematic literature search was conducted in the PubMed, PsycINFO, EMBASE and Web of Science databases from their inception to 11 June 2018. The prevalence of SA in BD was synthesised using the random-effects model.Results: The search identified 3451 articles of which 79 studies with 33 719 subjects met the study entry criteria. The lifetime prevalence of SA was 33.9% (95% CI 31.3–36.6%;I2= 96.4%). Subgroup and meta-regression analyses revealed that the lifetime prevalence of SA was positively associated with female gender, BD-I, BD Not Otherwise Specified and rapid cycling BD subtypes, income level and geographic region.Conclusion: This meta-analysis confirmed that SA is common in BD and identified a number of factors related to SA. Further efforts are necessary to facilitate the identification and prevention of SA in BD. Long-term use of mood stabilisers coupled with psycho-social interventions should be available to BD patients to reduce the risk of suicidal behaviour.
5 June 2006 in Applied Physics Letters
Journal Article
Zhen YuanHJHuabei Jiang
Huabei JiangWe report on experimental demonstration of photoacoustic tomography for reconstructing the optical absorption coefficient images of heterogeneous media. Photoacoustic images are obtained from a series of tissuelike phantom experiments using a finite element-based reconstruction algorithm coupled with a scanning photoacoustic imaging system. The experimental results show that optical absorption images can be quantitatively reconstructed when the photon diffusion model is coupled with the Helmholtz photoacoustic wave equation.
19 October 2020 in Angewandte Chemie International Edition
Journal Article
ZZZhan Zhang
Zhan Zhang
WSWei Sang
Wei Sang
LXLisi Xie
Lisi Xie
WLWenxi Li
Wenxi Li
BLBei Li
Bei Li
Yunlu Dai +4
About Me
Dr. Zhen Yuan is a Professor with Faculty of Health Sciences at the University of Macau and concurrently serves as the Head of the Centre for Cognitive and Brain Sciences with the university. Professor Yuan has achieved a series of internationally recognized in the fields of brain neuroscience and biomedical optics. He has published over 400 high-quality SCI-indexed papers in top journals including Science Advances, Nature Communications, Cell Reports, Cell Reports Physical Sciences, Cell Biomaterials, Research, Microbiome, Translational Psychiatry, Biological Psychiatry, and Molecular Psychiatry, Advanced Materials, Small, Advanced Functional Materials, Nano Letters, Advanced Sciences, ACS Nano, Biomaterials, Nano Micro Letters, Angewandte Chemie International Edition, Theranostics, Optics Letters, and Applied Physics Letters. His Google Scholar H-index is 65, with a total citation of around 14000.
Professor Yuan currently serves on the editorial board of Quantitative Imaging in Medicine and Surgery, Neuroelectronics, Heat and Mind, and Journal of Innovative Optical Health Sciences, and is also a Senior Associate Editor for BMC Medical Imaging and Frontiers in Human Neuroscience. He is a Fellow of the Optical Society of America (OSA) and a Fellow of Vebleo. He holds positions as a Standing Committee Member of the Biomedical Optics Committee of the Chinese Optical Society, Vice President of the Macau Society of Nuclear Medicine and Molecular Imaging, a Council Member of the
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