Under axial compression, multi-cell tubes are considered more effective than single-cell tubes. Regular hexagonal multi-cell tubes (HMT) were designed, tested, and analyzed by finite element modeling (FEM). The crushing mechanism of the HMT was revealed by compression testing and FEM. Experiments and FEM revealed that the mean crushing force of the HMT can be increased by 14% by adopting multi-cell topology, which shortens the folding wavelength and enables HMT progressive crushing. Thus, the HMT is more efficient in energy absorption compared with the conventional regular hexagonal thin-walled tube (HST). More triangular cells result in HMTs with much greater mean crushing force and specific energy absorption. Three evaluation methods were proposed and discussed to determine the effective crushing distance. A plastic model established according to classical simplified super-folding elements was shown to consistently predict the mean crushing force of the HMTs.