Environmental exposure to cadmium (Cd) or lead (Pb) is independently associated with increased risks of type 2 diabetes, and chronic kidney disease. The aim of this study was to examine the effects of concurrent exposure to these toxic metals on the risks of diabetes and kidney functional impairment. The Cd and Pb exposure levels among study subjects were low to moderate, evident from the means for blood concentrations of Cd and Pb ([Cd]_b and [Pb]_b) of 0.59 µg/L and 4.67 µg/dL, respectively. Of 176 study subjects (mean age 60), 71 (40.3%) had abnormally high fasting plasma glucose levels. Based on their [Cd]_b and [Pb]_b, 53, 71, and 52 subjects were assigned to Cd and Pb exposure profiles 1, 2, and 3, respectively. The diagnosis of diabetes was increased by 4.2-fold in those with an exposure profile 3 (p = 0.002), and by 2.9-fold in those with the estimated glomerular filtration (eGFR) ≤ 60 mL/min/1.73 m² (p = 0.029). The prevalence odds ratio (POR) for albuminuria was increased by 5-fold in those with plasma glucose levels above kidney threshold of 180 mg/dL (p = 0.014), and by 3.1-fold in those with low eGFR) (p = 0.050). Collectively, these findings suggest that the Cd and Pb exposure profiles equally impact kidney function and diabetes risk.

Introduction/Objectives: Type 2 diabetes (T2D) continues to pose a substantial global public health challenge. Current evidence has linked an increase in the risk of T2D to chronic exposure to the heavy metals cadmium (Cd) and lead (Pb). The present study aimed to examine whether the reported links existed in an area of southern Thailand with known Pb contamination. Materials and Methods: A case–control study design was used to recruit 88 diagnosed T2D cases and 90 age-, gender- and locality-matched non-diabetic controls. Blood levels of Cd and Pb were used as exposure indicators. Exposure-related risk factors and socio-demographic data were collected through questionnaires. Results: A significant association was found between blood Pb and T2D diagnosis, but the association between blood Cd and T2D was not statistically significant. Factors related to high Pb exposure were education, occupation, income, smoking habits, alcohol consumption, and dietary patterns, particularly the consumption of sweet and fatty foods. Participants with higher blood Pb levels had poorer glycemic control, thereby suggesting potential interference of Pb with oral hypoglycemic agents. Conclusions: This study confirms the connection between Pb exposure and increased risk of having T2D. Additionally, it identified socio-demographic factors, and consumption habits that contributed to such an enhanced T2D risk. The role of Cd exposure requires further studies, using urinary Cd excretion, which reflects long-term exposure conditions. These findings suggest the need to incorporate environmental and occupational exposure in diabetes care strategies. From the clinical and public health perspectives, targeted interventions should focus on reducing heavy metal exposure, improving risk awareness, and strengthening occupational safety measures to prevent disease progression.

This study aimed to assess health literacy (HL), preventive behaviors (PBs), and the factors associated with PBs toward COVID-19 among village health volunteers (VHVs) and residents in urban and rural areas in the upper south of Thailand. A cross-sectional study was conducted using valid questionnaires administered using an online platform. Data were analyzed using descriptive statistics, t-tests, and binary logistic regression analysis. A total of 846 people participated in this study, and 62.8% of participants had an adequate level of HL. Furthermore, 55.0% of participants had an adequate level of PBs. Among VHVs, PB levels were adequate, whereas among residents, they were inadequate. Moreover, among VHVs, underlying diseases (adjusted odds ratio (OR): 1.77, 95% CI: 1.13–2.76), access to HL (adjusted OR: 4.28, 95% CI: 1.42–12.88), appraisal of HL (adjusted OR: 3.09, 95% CI: 1.90–5.02), and application of HL (adjusted OR: 2.51, 95% CI: 1.52–4.12) were associated with COVID-19 PB. Additionally, among residents, only marital status (adjusted OR: 1.59, 95% CI: 1.04–2.44), appraisal of HL (adjusted OR: 1.78, 95% CI: 1.18–2.84), and application of HL (adjusted OR: 3.85, 95% CI: 2.39–6.20) were associated with PBs towards COVID-19. Furthermore, individuals with inadequate HL demonstrated noteworthy significance in all dimensions of PBs. To prioritize and optimize preventive programs aimed at enhancing PBs, the government must take proactive initiatives in implementing robust health communication strategies across diverse media platforms, both in the present and future.