Urolithin A (Uro A) is a dietary metabolite of the intestinal microbiota following the ingestion of plant-based food ingredients ellagitannins and ellagic acid in mammals. Accumulating studies have reported its multiple potential health benefits in a broad range of diseases, including cardiovascular disease, cancer, cognitive impairment, and diabetes. In particular, Uro A is safe via direct oral administration and is non-genotoxic. The pancreas plays a central role in regulating energy consumption and metabolism by secreting digestive enzymes and hormones. Numerous pathophysiological factors, such as inflammation, deficits of mitophagy, and endoplasmic reticulum stress, can negatively affect the pancreas, leading to pancreatic diseases, including pancreatitis, pancreatic cancer, and diabetes mellitus. Recent studies showed that Uro A activates autophagy and inhibits endoplasmic reticulum stress in the pancreas, thus decreasing oxidative stress, inflammation, and apoptosis. In this review, we summarize the knowledge of Uro A metabolism and biological activity in the gut, as well as the pathological features and mechanisms of common pancreatic diseases. Importantly, we focus on the potential activities of Uro A and the underlying mechanisms in ameliorating various pancreatic diseases via inhibiting inflammatory signaling pathways, activating autophagy, maintaining the mitochondrial function, and improving the immune microenvironment. It might present a novel nutritional strategy for the intervention and prevention of pancreatic diseases.

In recent years, there has been a significant increase in age-related diseases due to the improvement in life expectancy worldwide. The pancreas undergoes various morphological and pathological changes with aging, such as pancreatic atrophy, fatty degeneration, fibrosis, inflammatory cell infiltration, and exocrine pancreatic metaplasia. Meanwhile, these may predispose the individuals to aging-related diseases, such as diabetes, dyspepsia, pancreatic ductal adenocarcinoma, and pancreatitis, as the endocrine and exocrine functions of the pancreas are significantly affected by aging. Pancreatic senescence is associated with various underlying factors including genetic damage, DNA methylation, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and inflammation. This paper reviews the alternations of morphologies and functions in the aging pancreas, especially β-cells, closely related to insulin secretion. Finally, we summarize the mechanisms of pancreatic senescence to provide potential targets for treating pancreatic aging-related diseases.

Walking with load is a common task in daily life and disaster rescue. Long-term load carriage may cause irreversible damage to the human body. Although remarkable progress has been made in the field of wearable robots, it is still far from avoiding interference to human legs, which will lead to energy consumption. In this paper, a novel wearable robot, Centaur, for assisting load carriage has been proposed. The Centaur system consists of two rigid robotic legs of two degrees-of-freedom (DOFs) to transfer load weight to the ground. Different from exoskeletons, the robotic legs of the Centaur are placed behind the human rather than attached to human limbs, which can provide a larger support polygon and avoid additional interference to the wearer. Additionally, the Centaur can attain the locomotion stability of the quadruped while maintaining the motion agility of the biped itself. This paper also presents an interactive motion control strategy based on the human-robot interaction force. This control strategy incorporates legged robotics walking controller and real-time walking trajectory planning to realize the cooperative walking with human beings. Finally, experiments of human walking with load carriage have been conducted on flat terrain to verify the concept of the Centaur system. The result demonstrates that the Centaur system can effectively reduce 70.03% of load weight during the single stance phase, which indicates that the Centaur system provides a new solution for assisting human walking with load-carriage.