The technologies of ultrasound detection have a wide range of applications in marine science and industrial manufacturing. With the variation of the environment, the requirements of anti-interference, miniaturization, and ultra-sensitivity are put forward. Optical microcavities are often carefully designed for a variety of ultra-sensitive detections. Using the packaged microsphere cavity, we fabricated an ultrasound sensor that can work in an underwater environment. During practical detection, the optical resonance mode of the cavity can work with real-time response accordingly. The designed structure can work in various complex environments and has advantages in the fields of precision measurement and nano-particle detection.