Negative attitudes are a major barrier to the equality of people with disabilities. Governments and other organisations have implemented numerous programs to change attitudes towards people with disabilities. We analyse published evidence about the effectiveness of such programs using a framework of the interrelationship between three levels of policy intervention to change attitudes: personal level – directed at changing the attitudes of individuals; organisational level – concerning attitudinal barriers in domains such as employment, education and health; and government level – legally mandating behaviour change. The analysis finds that the following policy types can be effective if used together: policies that involve direct contact with people with disability; information and awareness campaigns; education and training about disability; and antidiscrimination enforcement. Policy characteristics that contribute to effectiveness include: a positive program experience for participants; multi-faceted and prolonged interventions; and adequate program resources. Policy effectiveness to change attitudes relies on corresponding reinforcement at all three policy levels