In response to the limitations of traditional one-size-fits-all models, health professions education is increasingly adopting personalized learning approaches that recognize individual learner differences. This review examines personalized learning in health professions education, focusing on its key principles, implementation strategies, and impact on learning outcomes. Literature searches were performed using PubMed, Scopus, and Google Scholar using specific keywords: “Personalized learning; Health professions education; education, Key principles; strategies for fostering personalized learning, learning outcomes; were reviewed by the authors. The key principles of personalized learning in health professions education centres are based on learner agency, learner-centeredness, self-Regulated learning and metacognition, and mastery-driven instruction tailored to individual needs. These strategies for implementing personalized learning include curriculum design, instructional methodologies, assessment methods, faculty development, and the integration of real-world clinical scenarios. Studies included in the current review have suggested several strategies to foster personalized learning in health professions education. The implementation of these strategies will enhance educational outcomes by improving knowledge retention, increasing learner engagement, strengthening overall academic performance, and better preparing students for clinical practice. In conclusion, Personalized learning in health professions education integrates learner-centered principles with competency-based progression, adaptive instruction, and continuous feedback to create responsive academic and clinical training environments. When implemented through structured curricular and assessment strategies, it enhances engagement, knowledge retention, clinical skill development, and long-term professional competence.