Context: Given the growing public health crisis caused by viral diseases, traditional medicine stands as one of the fundamental pillars for the study and discovery of phytometabolites with antiviral properties. It is necessary to investigate and evaluate these compounds, mostly phenolic, that could be used as drugs. Aims: To identify the polyphenols by UPLC-MS/MS and the potential in silico antiviral activity of medicinal plants in Trujillo, Peru. Methods: The ethnobotany of the eight most widely used medicinal plants in the city of Trujillo was described (Azadirachta indica A. Juss. “paradise”, Caesalpinia spinosa (Molina) Kuntze “tara”, Citrus limon (L.) Osbeck “lemon”, Clinopodium pulchellum (Kunth) Govaerts "panizara", Cordia lutea Lam. "overo", Ocimum basilicum L. "basil", Schinus molle L. "molle", and Taraxacum campylodes G.E. Haglund "dandelion"). The phytometabolites responsible for the antiviral activity were identified by LC-MS and evaluated in silico against the viral proteins NS2B/NS3 (DENV-2), NS5B (HCV), and ICP27 (HSV-1) by molecular docking using Chimera 1.16 software and molecular interaction by Maestro 13.1 software to identify the position and type of interaction. Results: Five polyphenols (chlorogenic acid, gallic acid, caffeic acid, rosmarinic acid, and rutin) were found, and in the in-silico test, the antiviral activity of chlorogenic acid stood out against DENV-2 and HCV, rutin against HCV and HSV-1, rosmarinic acid against DENV-2 and HCV. Conclusions: It is demonstrated that the medicinal plants studied contain phytometabolites that make them possible antiviral candidates, which would support their use in the traditional medicine of the province of Trujillo, Peru.

Uncaria tomentosa (Willd.) DC. (Rubiaceae): Especie nativa del Perú, medicamento herbolario reconocido por la medicina tradicional

Lippia alba (Mill.) N.E. Br. ex Britton & P. Wilson is an aromatic medicinal plant widely used in traditional medicine for the management of digestive, inflammatory, and infectious disorders. The present study aimed to investigate the ethnobotanical relevance, chemical composition, antioxidant, antifungal, antibacterial, and molecular docking properties of L. alba essential oil (EOLA). Ethnobotanical information was collected through semi-structured interviews with herbal vendors. The essential oil was obtained by hydrodistillation and chemically characterized by GC–MS and GC–FID, leading to the identification of 27 volatile constituents. The chemical profile was dominated by oxygenated monoterpenes (83.83%), with (−)-carvone (63.79%) and dihydrocarvyl acetate (17.74%) as the major compounds, confirming a carvone chemotype. EOLA exhibited moderate antioxidant activity, with values of 24.1 mg TE/100 g and 34.5 mg TE/100 g in the DPPH and ABTS assays, respectively. Furthermore, the essential oil demonstrated significant concentration-dependent antifungal and antibacterial activities against Candida albicans and Staphylococcus aureus. At the highest concentration tested, the antimicrobial activity approached that of the reference drugs. In silico ADMET analysis predicted favorable pharmacokinetic and drug-likeness properties for the major volatile constituents. Molecular docking studies revealed relevant interactions between several compounds, particularly α-gurjunene, alloaromadendrene, trans-α-bisabolene, and (−)-β-bourbonene, and molecular targets associated with oxidative stress and microbial inhibition, providing mechanistic insights into the biological activities observed experimentally. Overall, these findings support the ethnopharmacological use of L. alba and highlight its essential oil as a promising natural source of bioactive compounds with antioxidant and antimicrobial potential for future phytopharmaceutical applications.

Sleep quality is crucial during school age as it directly impacts children's development; however, understanding its influence on anthropometric profile during this vulnerable stage is essential. To determine the association between sleep quality and anthropometric profile in school-aged children from a sports academy in the city of Trujillo, Peru. Data were obtained through a non-experimental cross-sectional study involving 117 boys and girls aged 9 to 12 years. Sleep quality was measured using a survey technique, with the instrument being a sleep quality questionnaire developed by the researchers. Additionally, anthropometric profile was assessed using observational techniques, with the instrument being an anthropometric measurement record form. The p-values for body mass index (BMI), height for age (H/A), waist-to-height ratio and skinfold thickness were all greater than 0.05 (0.360; 0.661; 0.696; 0.312). There is no association between sleep quality and anthropometric profile, sleep quality had no impact on anthropometric profile.

Traditional medicine is one of the main bases for studying and discovering natural sources of phytometabolites with antiviral properties. This research aims to demonstrate that the medicinal plants used as a treatment of viral diseases in the La Libertad region have, in fact, antiviral ac-tivity. The study evaluated the ethnobotany of the 8 most widely used medicinal plants in the region (Azadirachta indica A. Juss. “paraíso”, Caesalpinia spinosa (Molina) Kuntze “tara”, Citrus limon (L.) Osbeck “limón”, Clinopodium pulchellum (Kunth) Govaerts “panizara”, Cordia lutea Lam. “overo”, Ocimum basilicum L. “albahaca”, Schinus molle L. “molle”, and Taraxacum campylodes G.E. Haglund “diente de león”). The phytometabolites responsible for the antiviral activity were identified by LC-MS and evaluated in silico against the viral proteins NS2B/NS3 (DENV-2), NS5B (HCV), and ICP27 (HSV-1) using molecular docking in Autodock Vina and UCSF Chimera. The presence of five polyphenols (chlorogenic acid, gallic acid, caffeic acid, rosmarinic acid, and rutin) was found and, in the in silico test, the antiviral activity of chlorogenic acid stood out against DENV-2 and HCV, rutin against HCV and HSV-1, rosmarinic acid against DENV-2 and HCV. Therefore, it is verified that the medicinal plants studied have antiviral activity, which supports their use in traditional medicine

El Rubus Ulmifolius o zarzamora es un alimento de alto contenido antioxidante considerado como planta medicinal con efecto analgésico, diurético, etc. Se propone que el Rubus Ulmifolius sea presentado en forma de goma con el fitofármaco niacina afín de reducir los cólicos menstruales. Durante este periodo, el mayor inconveniente de las mujeres se presenta como contracciones constantes del útero acompañado de síntomas de incapacidad para realizar actividades cotidianas. A través de la investigación aquí realizada, se ha comprobado que estos efectos pueden prevenirse con un producto elaborado a base de extracto de zarzamora con una presentación de fácil consumo para sustituir así a los analgésicos por uno elaborado a base de fruta orgánica con una efectividad comprobada como parte de la ayuda alimentaria para fomentar un consumo de alimentos nutraceúticos mejorando así el estilo de vida de la mujer y su desarrollo.