This paper selected three kinds of AC-20 hot-mix recycled asphalt mixtures with high RAP content (30%, 40%, and 50%). It obtains a mixture of different degrees of miscibility by changing RAP preheating temperatures and mixing temperatures. The calculation formula of the degree of blending (DOB) of RAP asphalt interface recycling is proposed. The DSR test quantitatively characterized the DOB mixture’s low temperature, and fatigue properties were tested by beam bending test and four-point bending fatigue test. The prediction models of the recycled mixture’s low temperature and fatigue properties were proposed. The RAP preheating temperature is the most critical factor that dominates both transfers of RAP asphalt to the surface of new aggregate and the effective blending of old and new asphalt. DOB has a significant great influence on low-temperature performance and fatigue performance. The DOB of recycled asphalt can be improved by adjusting and optimizing the process parameters of plant hot recycled mixture to effectively improve the recycled mixture’s low-temperature crack resistance and fatigue lifetime. The optimal RAP dosage and mixing process of required performance can be obtained based on the prediction models to save experimental time and cost.