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With the increasing burden of common neurodegenerative disorders and their long-hypothesized link with platelet biology, genomic approaches have been recently used to investigate the presence of a shared genetic basis between neurodegenerative risk and platelet parameters, reporting a significant though moderate genetic correlation between Parkinson Disease (PD) risk and platelet distribution width, an index of platelet size variability. Here, we investigated the genetic overlap of platelet parameters with an endophenotype of PD, age-at-onset (PD-AAO). First, we applied a Linkage Disequilibrium (LD)-score regression to the summary statistics of a large independent Genome Wide Association Study (GWAS) previously conducted, to estimate the co-heritability based on common genetic variants. Then, we analyzed multitrait single-variant associations to identify novel loci associated with both PD-AAO and mean platelet volume (MPV). Finally, we performed gene and gene-set enrichment analyses of these associations. We observed a statistically significant genetic correlation between MPV and PD-AAO (rg (SE) = −0.215 (0.082); p = 0.009). The multitrait analysis revealed eight novel variants associated with PD-AAO and 33 with MPV. The genes most significantly enriched for associations with PD-AAO included ARHGEF3 (Rho Guanine Nucleotide Exchange Factor 3), previously associated with depression, and KALRN (Kalirin RhoGEF Kinase), encoding a PINK1 interactor previously implicated in schizophrenia, Alzheimer Disease and PD itself. Interestingly, these genes were also identified in the analysis of MPV. The most significant gene-set enrichments shared between MPV and PD-AAO were observed for coagulation- and megakaryopoiesis-related pathways. These findings provide novel hints into the common genetic basis of PD endophenotypes, platelet biology and its neuropsychiatric comorbidities, paving the way for investigating common underlying mechanisms.
Alfonsina Tirozzi; Roberta Parisi; Chiara Cerletti; Maria Donati; Giovanni de Gaetano; Licia Iacoviello; Alessandro Gialluisi. Genomic Overlap between Platelet Parameters Variability and Age at Onset of Parkinson Disease. Applied Sciences 2021, 11, 6927 .
AMA StyleAlfonsina Tirozzi, Roberta Parisi, Chiara Cerletti, Maria Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi. Genomic Overlap between Platelet Parameters Variability and Age at Onset of Parkinson Disease. Applied Sciences. 2021; 11 (15):6927.
Chicago/Turabian StyleAlfonsina Tirozzi; Roberta Parisi; Chiara Cerletti; Maria Donati; Giovanni de Gaetano; Licia Iacoviello; Alessandro Gialluisi. 2021. "Genomic Overlap between Platelet Parameters Variability and Age at Onset of Parkinson Disease." Applied Sciences 11, no. 15: 6927.
Background: Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19, but its association with mortality is unclear. We reviewed published literature for evidence of an association between HCQ (with or without azithromycin (AZM)) and total mortality in COVID-19 patients. Methods: Articles were retrieved until April 29th, 2021 by searching in seven databases. Data were combined using the general-variance-based method. Results: A total of 25 cohort studies (N=41,339 patients) and 11 randomized clinical trials (RCTs; N=8,709) were found. The use of HCQ was not associated with mortality in meta-analysis of RCTs (pooled risk ratio (PRR): 1.08, 95%CI: 0.97-1.20; I2=0%), but it was associated with 20% lower mortality risk (PRR=0.80, 95%CI: 0.69-0.93; I2=80%) in pooling of cohort studies. The negative association with mortality was mainly apparent by pooling cohort studies that used lower doses of HCQ (≤400 mg/day; PRR=0.69, 95%CI: 0.57-0.87). Use of HCQ+AZM (11 studies) was associated with 25% non-statistically significant lower mortality risk (PPR=0.75; 0.51-1.10; P=0.15). Use of HCQ was not associated with severe adverse events (PRR=1.12, 95%CI: 0.88-1.44; I2=0%). Conclusions: HCQ use was not associated with mortality in COVID-19 patients in pooling results from RCTs (high level of certainty of evidence), but it was associated with 20% mortality reduction when findings from observational studies were combined (low level of certainty of evidence). The reduction of mortality was mainly apparent in observational studies where lower doses of HCQ were used. These findings might help disentangling the debate on HCQ use in COVID-19.
Augusto Di Castelnuovo; Simona Costanzo; Antonio Cassone; Roberto Cauda; Giovanni De Gaetano; Licia Iacoviello. Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials. Pathogens and Global Health 2021, 1 -11.
AMA StyleAugusto Di Castelnuovo, Simona Costanzo, Antonio Cassone, Roberto Cauda, Giovanni De Gaetano, Licia Iacoviello. Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials. Pathogens and Global Health. 2021; ():1-11.
Chicago/Turabian StyleAugusto Di Castelnuovo; Simona Costanzo; Antonio Cassone; Roberto Cauda; Giovanni De Gaetano; Licia Iacoviello. 2021. "Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials." Pathogens and Global Health , no. : 1-11.
Biological aging, or the discrepancy between biological and chronological age of a subject (Δage), has been associated with a polyphenol-rich Mediterranean diet and represents a new, robust indicator of cardiovascular disease risk. We aimed to disentangle the relationship of dietary polyphenols and total antioxidant capacity with Δage in a cohort of Italians. A cross-sectional analysis was performed on a sub-cohort of 4592 subjects (aged ≥ 35 y; 51.8% women) from the Moli-sani Study (2005–2010). Food intake was recorded by a 188-item food-frequency questionnaire. The polyphenol antioxidant content (PAC)-score was constructed to assess the total dietary content of polyphenols. Total antioxidant capacity was measured in foods by these assays: trolox equivalent antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP) and ferric reducing-antioxidant power (FRAP). A deep neural network, based on 36 circulating biomarkers, was used to compute biological age and the resulting Δage, which was tested as outcome in multivariable-adjusted linear regressions. Δage was inversely associated with the PAC-score (β = −0.31; 95%CI −0.39, −0.24) but not with total antioxidant capacity of the diet. A diet rich in polyphenols, by positively contributing to deceleration of the biological aging process, may exert beneficial effects on the long-term risk of cardiovascular disease and possibly of bone health.
Simona Esposito; Alessandro Gialluisi; Simona Costanzo; Augusto Di Castelnuovo; Emilia Ruggiero; Amalia De Curtis; Mariarosaria Persichillo; Chiara Cerletti; Maria Donati; Giovanni de Gaetano; Licia Iacoviello; Marialaura Bonaccio; on behalf of the Investigators for the Moli-Sani Study. Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study. Nutrients 2021, 13, 1701 .
AMA StyleSimona Esposito, Alessandro Gialluisi, Simona Costanzo, Augusto Di Castelnuovo, Emilia Ruggiero, Amalia De Curtis, Mariarosaria Persichillo, Chiara Cerletti, Maria Donati, Giovanni de Gaetano, Licia Iacoviello, Marialaura Bonaccio, on behalf of the Investigators for the Moli-Sani Study. Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study. Nutrients. 2021; 13 (5):1701.
Chicago/Turabian StyleSimona Esposito; Alessandro Gialluisi; Simona Costanzo; Augusto Di Castelnuovo; Emilia Ruggiero; Amalia De Curtis; Mariarosaria Persichillo; Chiara Cerletti; Maria Donati; Giovanni de Gaetano; Licia Iacoviello; Marialaura Bonaccio; on behalf of the Investigators for the Moli-Sani Study. 2021. "Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study." Nutrients 13, no. 5: 1701.
We investigated the effect of confinement during the COVID-19 pandemic on the consumption of foods characterising the Mediterranean dietary pattern (MDP) and its major correlates in two Italian population-based cohorts comprising 3161 subjects (mean age 57.7 ± 15.4 y). At population level, 38.8% of participants reported an improvement of diet quality during the first nationwide lockdown. Healthful dietary changes were associated with older age (β = 0.41; 95% confidence interval [CI] 0.08, 0.73 for 56–65 vs. 18–39 y), greater wealth (β = 0.45; 0.01, 0.89 for >40,000 ≤ 60,000 vs. ≤ 10,000 EUR/y), increased physical activity (β = 0.52; 0.22, 0.81) and reduced body weight (β = 0.36; 0.11, 0.62). Switching to healthy eating was also related to increased consumption of organic (β = 1.24; 0.88, 1.60) and locally-grown food (β = 0.74; 0.51, 0.96). The first Italian lockdown led, in a substantial part of the population, to higher intake of foods characterising a MDP; this was also accompanied by healthier lifestyle and more sustainable food choices.
Emilia Ruggiero; Cristiana Mignogna; Simona Costanzo; Mariarosaria Persichillo; Augusto Di Castelnuovo; Simona Esposito; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello; Marialaura Bonaccio; for the Moli-LOCK Study Investigators. Changes in the consumption of foods characterising the Mediterranean dietary pattern and major correlates during the COVID-19 confinement in Italy: results from two cohort studies. International Journal of Food Sciences and Nutrition 2021, 1 -13.
AMA StyleEmilia Ruggiero, Cristiana Mignogna, Simona Costanzo, Mariarosaria Persichillo, Augusto Di Castelnuovo, Simona Esposito, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Marialaura Bonaccio, for the Moli-LOCK Study Investigators. Changes in the consumption of foods characterising the Mediterranean dietary pattern and major correlates during the COVID-19 confinement in Italy: results from two cohort studies. International Journal of Food Sciences and Nutrition. 2021; ():1-13.
Chicago/Turabian StyleEmilia Ruggiero; Cristiana Mignogna; Simona Costanzo; Mariarosaria Persichillo; Augusto Di Castelnuovo; Simona Esposito; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello; Marialaura Bonaccio; for the Moli-LOCK Study Investigators. 2021. "Changes in the consumption of foods characterising the Mediterranean dietary pattern and major correlates during the COVID-19 confinement in Italy: results from two cohort studies." International Journal of Food Sciences and Nutrition , no. : 1-13.
Neuromedin U (NMU) is a neuropeptide involved in gut-brain axis, energy balance and immune response. We aimed at analysing the association between NMU epigenetic variability and metabolic indices and the potential mediating role of low-grade inflammation in a general population of Italian adults. NMU Blood DNA methylation levels at two CpG islands (NMU76 and NMU32) were analysed using pyrosequencing in a randomly selected sub-cohort of 1,160 subjects from the Moli-sani study (≥35years; 49.20% men). Multivariable regressions adjusted for age, sex, smoking, alcohol and vegetable consumption were performed to estimate the associations between methylation and metabolic phenotypes (BMI, waist-to-hip ratio, blood pressure, glucose, HOMA-IR, lipids, lipoprotein(a) and apolipoproteins). Mediation analysis was performed to identify the influence of low-grade inflammation in the association using a composite index based on C reactive protein, granulocyte-to-lymphocyte ratio (GLR), platelet and white blood cell counts (INFLA-score). Using principal component analysis four methylation factors were identified: NMU76-F1, NMU76-F2, NMU32-F1 and NMU32-F2. NMU76-F1 was FDR significantly associated with total cholesterol (for 1 SD increase: β = 4.5 ± 1.4 mg/dL of, R2 = 10.8%, p = 0.001), ApoB (0.03 ± 0.01 g/L, 12.2%, p = 0.0004), with INFLA-score (1.05 ± 0.22, p = 2.7E-6) and GLR (-0.27 ± 0.03, 30.4%, p = 1.3E-20). GLR and lymphocyte number mediate the association of NMU76-F1 with cholesterol (24.0% of total effect, Sobel p = 0.013) and ApoB (42.6%, p = 9E-7), respectively. These findings suggest that NMU promoter methylation patterns could mark a pathway linking lipids with haematopoiesis and systemic inflammation.
Annalisa Marotta; Fabrizia Noro; Roberta Parisi; Alessandro Gialluisi; Alfonsina Tirozzi; Amalia De Curtis; Simona Costanzo; Augusto Di Castelnuovo; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello; Benedetta Izzi; Francesco Gianfagna. NMU DNA methylation in blood is associated with metabolic and inflammatory indices: results from the Moli-sani study. Epigenetics 2021, 1 -14.
AMA StyleAnnalisa Marotta, Fabrizia Noro, Roberta Parisi, Alessandro Gialluisi, Alfonsina Tirozzi, Amalia De Curtis, Simona Costanzo, Augusto Di Castelnuovo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Benedetta Izzi, Francesco Gianfagna. NMU DNA methylation in blood is associated with metabolic and inflammatory indices: results from the Moli-sani study. Epigenetics. 2021; ():1-14.
Chicago/Turabian StyleAnnalisa Marotta; Fabrizia Noro; Roberta Parisi; Alessandro Gialluisi; Alfonsina Tirozzi; Amalia De Curtis; Simona Costanzo; Augusto Di Castelnuovo; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello; Benedetta Izzi; Francesco Gianfagna. 2021. "NMU DNA methylation in blood is associated with metabolic and inflammatory indices: results from the Moli-sani study." Epigenetics , no. : 1-14.
Alongside their function in primary hemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic.
Benedetta Izzi; Alfonsina Tirozzi; Chiara Cerletti; Maria Benedetta Donati; Giovanni De Gaetano; Marc F. Hoylaerts; Licia Iacoviello; Alessandro Gialluisi. Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities. International Journal of Molecular Sciences 2020, 21, 8817 .
AMA StyleBenedetta Izzi, Alfonsina Tirozzi, Chiara Cerletti, Maria Benedetta Donati, Giovanni De Gaetano, Marc F. Hoylaerts, Licia Iacoviello, Alessandro Gialluisi. Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities. International Journal of Molecular Sciences. 2020; 21 (22):8817.
Chicago/Turabian StyleBenedetta Izzi; Alfonsina Tirozzi; Chiara Cerletti; Maria Benedetta Donati; Giovanni De Gaetano; Marc F. Hoylaerts; Licia Iacoviello; Alessandro Gialluisi. 2020. "Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities." International Journal of Molecular Sciences 21, no. 22: 8817.
The health benefits of moderate wine consumption have been extensively studied during the last few decades. Some studies have demonstrated protective associations between moderate drinking and several diseases including oral cavity cancer (OCC). However, due to the various adverse effects related to ethanol content, the recommendation of moderate wine consumption has been controversial. The polyphenolic components of wine contribute to its beneficial effects with different biological pathways, including antioxidant, lipid regulating and anti-inflammatory effects. On the other hand, in the oral cavity, ethanol is oxidized to form acetaldehyde, a metabolite with genotoxic properties. This review is a critical compilation of both the beneficial and the detrimental effects of wine consumption on OCC.
Paula Silva; Norbert Latruffe; Giovanni De Gaetano. Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus. Molecules 2020, 25, 2569 .
AMA StylePaula Silva, Norbert Latruffe, Giovanni De Gaetano. Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus. Molecules. 2020; 25 (11):2569.
Chicago/Turabian StylePaula Silva; Norbert Latruffe; Giovanni De Gaetano. 2020. "Wine Consumption and Oral Cavity Cancer: Friend or Foe, Two Faces of Janus." Molecules 25, no. 11: 2569.
Zinc finger and BTB domain-containing protein 12 (ZBTB12) is a predicted transcription factor with potential role in hematopoietic development. Recent evidence linked low methylation level of ZBTB12 exon1 to myocardial infarction (MI) risk. However, the role of ZBTB12 in the pathogenesis of MI and cardiovascular disease in general is not yet clarified. We investigated the relation between ZBTB12 methylation and several blood parameters related to cardio-cerebrovascular risk in an Italian family-based cohort. ZBTB12 methylation was analyzed on white blood cells from the Moli-family cohort using the Sequenom EpiTYPER MassARRAY (Agena). A total of 13 CpG Sequenom units were analyzed in the small CpG island located in the only translated ZBTB12 exon. Principal component analysis (PCA) was performed to identify groups of CpG units with similar methylation estimates. Linear mixed effect regressions showed a positive association between methylation of ZBTB12 Factor 2 (including CpG units 8, 9–10, 16, 21) and TNF-ɑ stimulated procoagulant activity, a measure of procoagulant and inflammatory potential of blood cells. In addition, we also found a negative association between methylation of ZBTB12 Factor 1 (mainly characterized by CpG units 1, 3–4, 5, 11, and 26) and white blood cell and granulocyte counts. An in silico prediction analysis identified granulopoiesis- and hematopoiesis-specific transcription factors to potentially bind DNA sequences encompassing CpG1, CpG3–4, and CpG11. ZBTB12 hypomethylation is linked to shorter TNF-ɑ stimulated whole blood coagulation time and increased WBC and granulocyte counts, further elucidating the possible link between ZBTB12 methylation and cardiovascular disease risk.
Fabrizia Noro; on behalf of the Moli-family study Investigators; Francesco Gianfagna; Alessandro Gialluisi; Amalia De Curtis; Augusto Di Castelnuovo; Emanuela Napoleone; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Marc F. Hoylaerts; Licia Iacoviello; Benedetta Izzi. ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort. Clinical Epigenetics 2019, 11, 74 .
AMA StyleFabrizia Noro, on behalf of the Moli-family study Investigators, Francesco Gianfagna, Alessandro Gialluisi, Amalia De Curtis, Augusto Di Castelnuovo, Emanuela Napoleone, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc F. Hoylaerts, Licia Iacoviello, Benedetta Izzi. ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort. Clinical Epigenetics. 2019; 11 (1):74.
Chicago/Turabian StyleFabrizia Noro; on behalf of the Moli-family study Investigators; Francesco Gianfagna; Alessandro Gialluisi; Amalia De Curtis; Augusto Di Castelnuovo; Emanuela Napoleone; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Marc F. Hoylaerts; Licia Iacoviello; Benedetta Izzi. 2019. "ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort." Clinical Epigenetics 11, no. 1: 74.
The association between obesity and mortality in the elderly remains controversial. To test the association between BMI and mortality, with the hypothesis of a mediation by low-grade inflammation (LGI), a prospective study design (median follow-up 7.8 years) was used on a sample of 4,970 elderly subjects (age ≥ 65 years) from the Moli-sani Study cohort. The association between BMI categories and overall or cause-specific mortality (hazard ratio, HR) was calculated by multivariable Cox regression. Dose-response relationship was tested using restricted cubic splines. Interaction between BMI and LGI, assessed through high-sensitivity C-reactive protein (hs-CRP) and INFLA-score, was also tested. In comparison with normal-weight, overweight was significantly associated with a 20% (adjusted HR = 0.80; 95%CI 0.67–0.95) reduced risk of total mortality, while severe obesity (BMI > 40) with an increased risk (HR = 1.81; 95%CI 1.13–2.93). Cubic spline curves showed a U-shaped relationship between BMI and total mortality (p value for nonlinear relationship = 0.001). Similar results were found for cardio-cerebrovascular and other causes mortality. Hs-CRP and INFLA-score were associated with an increased risk of total mortality in adjusted analyses. Mediation analysis did not show any effect of LGI on the association between BMI and mortality. However, after stratification for LGI under or below the population median, greater LGI increased the risk of mortality in obese elderly more than expected (p for interaction = 0.04). A U-shaped association between BMI and mortality was observed in Italian elderly subjects. While the association was independent of LGI levels, there was a significant interaction between BMI and LGI in increasing mortality risk in obese elderly individuals.
Giacomo Crotti; Francesco Gianfagna; Marialaura Bonaccio; Augusto Di Castelnuovo; Simona Costanzo; Mariarosaria Persichillo; Amalia De Curtis; Chiara Cerletti; Maria Benedetta Donati; Giovanni De Gaetano; Licia Iacoviello. Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation? Immunological Investigations 2018, 47, 774 -789.
AMA StyleGiacomo Crotti, Francesco Gianfagna, Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Mariarosaria Persichillo, Amalia De Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni De Gaetano, Licia Iacoviello. Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation? Immunological Investigations. 2018; 47 (8):774-789.
Chicago/Turabian StyleGiacomo Crotti; Francesco Gianfagna; Marialaura Bonaccio; Augusto Di Castelnuovo; Simona Costanzo; Mariarosaria Persichillo; Amalia De Curtis; Chiara Cerletti; Maria Benedetta Donati; Giovanni De Gaetano; Licia Iacoviello. 2018. "Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation?" Immunological Investigations 47, no. 8: 774-789.
S Costanzo; K Mukamal; A Di Castelnuovo; M Bonaccio; M Olivieri; M Persichillo; A De Curtis; C Cerletti; Mb Donati; G De Gaetano; L Iacoviello. Impact of Alcohol Consumption upon Healthcare Utilization: Evidence from Moli-sani study. The European Journal of Public Health 2018, 28, 1 .
AMA StyleS Costanzo, K Mukamal, A Di Castelnuovo, M Bonaccio, M Olivieri, M Persichillo, A De Curtis, C Cerletti, Mb Donati, G De Gaetano, L Iacoviello. Impact of Alcohol Consumption upon Healthcare Utilization: Evidence from Moli-sani study. The European Journal of Public Health. 2018; 28 (suppl_4):1.
Chicago/Turabian StyleS Costanzo; K Mukamal; A Di Castelnuovo; M Bonaccio; M Olivieri; M Persichillo; A De Curtis; C Cerletti; Mb Donati; G De Gaetano; L Iacoviello. 2018. "Impact of Alcohol Consumption upon Healthcare Utilization: Evidence from Moli-sani study." The European Journal of Public Health 28, no. suppl_4: 1.
M Bonaccio; A Di Castelnuovo; S Costanzo; M Persichillo; C Cerletti; Mb Donati; G De Gaetano; L Iacoviello. Combined impact of healthy lifestyle factors on survival in the elderly. The European Journal of Public Health 2018, 28, 1 .
AMA StyleM Bonaccio, A Di Castelnuovo, S Costanzo, M Persichillo, C Cerletti, Mb Donati, G De Gaetano, L Iacoviello. Combined impact of healthy lifestyle factors on survival in the elderly. The European Journal of Public Health. 2018; 28 (suppl_4):1.
Chicago/Turabian StyleM Bonaccio; A Di Castelnuovo; S Costanzo; M Persichillo; C Cerletti; Mb Donati; G De Gaetano; L Iacoviello. 2018. "Combined impact of healthy lifestyle factors on survival in the elderly." The European Journal of Public Health 28, no. suppl_4: 1.
E Ruggiero; M Bonaccio; A De Curtis; S Costanzo; M Persichillo; A Di Castelnuovo; F Gianfagna; C Cerletti; Mb Donati; G De Gaetano; L Iacoviello. Association of Mediterranean diet with emerging biomarkers of cardiovascular risk. The European Journal of Public Health 2018, 28, 1 .
AMA StyleE Ruggiero, M Bonaccio, A De Curtis, S Costanzo, M Persichillo, A Di Castelnuovo, F Gianfagna, C Cerletti, Mb Donati, G De Gaetano, L Iacoviello. Association of Mediterranean diet with emerging biomarkers of cardiovascular risk. The European Journal of Public Health. 2018; 28 (suppl_4):1.
Chicago/Turabian StyleE Ruggiero; M Bonaccio; A De Curtis; S Costanzo; M Persichillo; A Di Castelnuovo; F Gianfagna; C Cerletti; Mb Donati; G De Gaetano; L Iacoviello. 2018. "Association of Mediterranean diet with emerging biomarkers of cardiovascular risk." The European Journal of Public Health 28, no. suppl_4: 1.
Objective To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding. Methods We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 years and older with a group of age- and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) between 2002 and 2014. Participants were dichotomized into excessive drinkers (>45 g of alcohol) and light to moderate drinkers or nondrinkers. To isolate the unconfounded effect of alcohol on ICH, we used causal directed acyclic graphs and the back-door criterion to select a minimal sufficient adjustment set(s) of variables for multivariable analyses. Analyses were performed on the whole group as well as separately for lobar and deep ICH. Results We analyzed 3,173 patients (1,471 lobar ICH and 1,702 deep ICH) and 3,155 controls. After adjusting for the preselected variables in the minimal sufficient adjustments, heavy alcohol intake was associated with deep ICH risk (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.36–2.09) as well as with the overall risk of ICH (OR, 1.38; 95% CI, 1.17–1.63), whereas no effect was found for lobar ICH (OR, 1.01; 95% CI, 0.77–1.32). Conclusions In white people aged 55 years and older, high alcohol intake might exert a causal effect on ICH, with a prominent role in the vascular pathologies underlying deep ICH.
Paolo Costa; Mario Grassi; Licia Iacoviello; Marialuisa Zedde; Simona Marcheselli; Giorgio Silvestrelli; Maria Luisa DeLodovici; Maria Sessa; Andrea Zini; Maurizio Paciaroni; Cristiano Azzini; Massimo Gamba; Massimo Del Sette; Antonella Toriello; Carlo Gandolfo; Domenico Marco Bonifati; Rossana Tassi; Anna Cavallini; Alberto Chiti; Rocco Salvatore Calabrò; Francesco Grillo; Paolo Bovi; Giampaolo Tomelleri; Augusto Di Castelnuovo; Marco Ritelli; Giancarlo Agnelli; Alessandro De Vito; Nicola Pugliese; Giuseppe Martini; Corrado Lodigiani; Andrea Morotti; Loris Poli; Valeria De Giuli; Filomena Caria; Claudio Cornali; Giovanni de Gaetano; Marina Colombi; Alessandro Padovani; Alessandro Pezzini. Alcohol intake and the risk of intracerebral hemorrhage in the elderly. Neurology 2018, 91, e227 -e235.
AMA StylePaolo Costa, Mario Grassi, Licia Iacoviello, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Maria Luisa DeLodovici, Maria Sessa, Andrea Zini, Maurizio Paciaroni, Cristiano Azzini, Massimo Gamba, Massimo Del Sette, Antonella Toriello, Carlo Gandolfo, Domenico Marco Bonifati, Rossana Tassi, Anna Cavallini, Alberto Chiti, Rocco Salvatore Calabrò, Francesco Grillo, Paolo Bovi, Giampaolo Tomelleri, Augusto Di Castelnuovo, Marco Ritelli, Giancarlo Agnelli, Alessandro De Vito, Nicola Pugliese, Giuseppe Martini, Corrado Lodigiani, Andrea Morotti, Loris Poli, Valeria De Giuli, Filomena Caria, Claudio Cornali, Giovanni de Gaetano, Marina Colombi, Alessandro Padovani, Alessandro Pezzini. Alcohol intake and the risk of intracerebral hemorrhage in the elderly. Neurology. 2018; 91 (3):e227-e235.
Chicago/Turabian StylePaolo Costa; Mario Grassi; Licia Iacoviello; Marialuisa Zedde; Simona Marcheselli; Giorgio Silvestrelli; Maria Luisa DeLodovici; Maria Sessa; Andrea Zini; Maurizio Paciaroni; Cristiano Azzini; Massimo Gamba; Massimo Del Sette; Antonella Toriello; Carlo Gandolfo; Domenico Marco Bonifati; Rossana Tassi; Anna Cavallini; Alberto Chiti; Rocco Salvatore Calabrò; Francesco Grillo; Paolo Bovi; Giampaolo Tomelleri; Augusto Di Castelnuovo; Marco Ritelli; Giancarlo Agnelli; Alessandro De Vito; Nicola Pugliese; Giuseppe Martini; Corrado Lodigiani; Andrea Morotti; Loris Poli; Valeria De Giuli; Filomena Caria; Claudio Cornali; Giovanni de Gaetano; Marina Colombi; Alessandro Padovani; Alessandro Pezzini. 2018. "Alcohol intake and the risk of intracerebral hemorrhage in the elderly." Neurology 91, no. 3: e227-e235.
Platelet count represents a useful tool in clinical practice to discriminate individuals at higher risk of bleeding. Less obvious is the role of platelet count variability within the normal range of distribution in shaping the individual's disease risk profile. Epidemiological studies have shown that platelet count in the adult general population, is associated with a number of health outcomes related to haemostasis and thrombosis. However, recent studies are suggesting a possible role of this platelet index also as an independent risk factor. In this review of adult population studies, we will first focus on known genetic and non‐genetic determinants of platelet number variability. Next, we will evaluate platelet count as a marker and/or a predictor of disease risk and its interaction with other risk factors. We will then discuss the role of platelet count variability within the normal distribution range as a contribution to disease/mortality risk. The possibility of considering platelet count as a simple, inexpensive indicator of increased risk of disease and death in general populations could open new opportunities to investigate novel platelet pathophysiological roles as well as therapeutic opportunities. Future studies should also consider platelet count, not only platelet function, as a modulator of disease/mortality risk. This article is protected by copyright. All rights reserved.
Benedetta Izzi; Marialaura Bonaccio; Giovanni De Gaetano; Chiara Cerletti. Learning by counting blood platelets in population studies: survey and perspective a long way after Bizzozero. Journal of Thrombosis and Haemostasis 2018, 16, 1711 -1721.
AMA StyleBenedetta Izzi, Marialaura Bonaccio, Giovanni De Gaetano, Chiara Cerletti. Learning by counting blood platelets in population studies: survey and perspective a long way after Bizzozero. Journal of Thrombosis and Haemostasis. 2018; 16 (9):1711-1721.
Chicago/Turabian StyleBenedetta Izzi; Marialaura Bonaccio; Giovanni De Gaetano; Chiara Cerletti. 2018. "Learning by counting blood platelets in population studies: survey and perspective a long way after Bizzozero." Journal of Thrombosis and Haemostasis 16, no. 9: 1711-1721.
The polyphenol content of the diet was associated with reduced mortality risk in a Mediterranean population, possibly through an antiinflammatory mechanism.
George Pounis; Simona Costanzo; Marialaura Bonaccio; Augusto Di Castelnuovo; Amalia de Curtis; Emilia Ruggiero; Mariarosaria Persichillo; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello; Jos Vermylen; Ignacio De Paula Carrasco; Simona Giampaoli; Antonio Spagnuolo; Deodato Assanelli; Vincenzo Centritto; Pasquale Spagnuolo; Dante Staniscia; Americo Bonanni; Roberto Lorenzet; Antonio Mascioli; Marco Olivieri; Domenico Rotilio; Francesco Gianfagna; Maurizio Giacci; Antonella Padulo; Dario Petraroia; Sara Magnacca; Federico Marracino; Maria Spinelli; Christian Silvestri; Giuseppe Dell'Elba; Claudio Grippi; Francesca De Lucia; Branislav Vohnout; Angelita Verna; Maura Di Lillo; Irene Di Stefano; Agnieszka Pampuch; Agostino Pannichella; Antonio Rinaldo Vizzarri; Daniela Barbato; Francesca Bracone; Carmine Di Giorgio; Simona Panebianco; Antonello Chiovitti; Sergio Caccamo; Vanesa Caruso; Daniela Cugino; Francesco Zito; Alessandra Ferri; Concetta Castaldi; Marcella Mignogna; Tomasz Guszcz; Paola Barisciano; Lorena Buonaccorsi; Floriana Centritto; Antonella Cutrone; Francesca Fanelli; Iolanda Santimone; Anna Sciarretta; Isabella Sorella; Emanuela Plescia; Alessandra Molinaro; Christiana Cavone; Giovanna Galuppo; Dolores D'Angelo; Rosanna Ramacciato. Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study. Nutrition 2018, 48, 87 -95.
AMA StyleGeorge Pounis, Simona Costanzo, Marialaura Bonaccio, Augusto Di Castelnuovo, Amalia de Curtis, Emilia Ruggiero, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Jos Vermylen, Ignacio De Paula Carrasco, Simona Giampaoli, Antonio Spagnuolo, Deodato Assanelli, Vincenzo Centritto, Pasquale Spagnuolo, Dante Staniscia, Americo Bonanni, Roberto Lorenzet, Antonio Mascioli, Marco Olivieri, Domenico Rotilio, Francesco Gianfagna, Maurizio Giacci, Antonella Padulo, Dario Petraroia, Sara Magnacca, Federico Marracino, Maria Spinelli, Christian Silvestri, Giuseppe Dell'Elba, Claudio Grippi, Francesca De Lucia, Branislav Vohnout, Angelita Verna, Maura Di Lillo, Irene Di Stefano, Agnieszka Pampuch, Agostino Pannichella, Antonio Rinaldo Vizzarri, Daniela Barbato, Francesca Bracone, Carmine Di Giorgio, Simona Panebianco, Antonello Chiovitti, Sergio Caccamo, Vanesa Caruso, Daniela Cugino, Francesco Zito, Alessandra Ferri, Concetta Castaldi, Marcella Mignogna, Tomasz Guszcz, Paola Barisciano, Lorena Buonaccorsi, Floriana Centritto, Antonella Cutrone, Francesca Fanelli, Iolanda Santimone, Anna Sciarretta, Isabella Sorella, Emanuela Plescia, Alessandra Molinaro, Christiana Cavone, Giovanna Galuppo, Dolores D'Angelo, Rosanna Ramacciato. Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study. Nutrition. 2018; 48 ():87-95.
Chicago/Turabian StyleGeorge Pounis; Simona Costanzo; Marialaura Bonaccio; Augusto Di Castelnuovo; Amalia de Curtis; Emilia Ruggiero; Mariarosaria Persichillo; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello; Jos Vermylen; Ignacio De Paula Carrasco; Simona Giampaoli; Antonio Spagnuolo; Deodato Assanelli; Vincenzo Centritto; Pasquale Spagnuolo; Dante Staniscia; Americo Bonanni; Roberto Lorenzet; Antonio Mascioli; Marco Olivieri; Domenico Rotilio; Francesco Gianfagna; Maurizio Giacci; Antonella Padulo; Dario Petraroia; Sara Magnacca; Federico Marracino; Maria Spinelli; Christian Silvestri; Giuseppe Dell'Elba; Claudio Grippi; Francesca De Lucia; Branislav Vohnout; Angelita Verna; Maura Di Lillo; Irene Di Stefano; Agnieszka Pampuch; Agostino Pannichella; Antonio Rinaldo Vizzarri; Daniela Barbato; Francesca Bracone; Carmine Di Giorgio; Simona Panebianco; Antonello Chiovitti; Sergio Caccamo; Vanesa Caruso; Daniela Cugino; Francesco Zito; Alessandra Ferri; Concetta Castaldi; Marcella Mignogna; Tomasz Guszcz; Paola Barisciano; Lorena Buonaccorsi; Floriana Centritto; Antonella Cutrone; Francesca Fanelli; Iolanda Santimone; Anna Sciarretta; Isabella Sorella; Emanuela Plescia; Alessandra Molinaro; Christiana Cavone; Giovanna Galuppo; Dolores D'Angelo; Rosanna Ramacciato. 2018. "Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study." Nutrition 48, no. : 87-95.
Evidence indicates that Vitamin D deficiency may be associated with increased risk of cardiovascular disease, although findings on risk of heart failure (HF) are controversial. We investigated the relationship between serum Vitamin D and the incidence of hospitalization for HF in a large prospective cohort of Italian adults.19,092 (49% men, age range 35-99 years) HF-free individuals from the Moli-sani study, with complete data on serum Vitamin D (25-hydroxyvitamin) levels and incident hospitalized HF, were analysed. The cohort was followed up for a median of 6.2 years. Baseline serum Vitamin D levels were categorized in deficient (<10 ng/mL), insufficient (10-29 ng/mL), and normal (≥30 ng/mL) Incident cases of hospitalization for HF were identified by linkage with the regional hospital discharge registry. Hazard ratios (HRs) were calculated using Cox-proportional hazard models. The prevalence of normal, insufficient or deficient levels of Vitamin D was 12.2%, 79.6% and 8.2%, respectively. During follow-up, 562 admissions to hospital for HF were identified. The incidence of HF was 1.6%, 2.9% and 5.3%, respectively in subjects with normal, insufficient and deficient levels of Vitamin D. After multivariable analysis, individuals with deficiency of Vitamin D had a higher risk of hospitalization for HF (HR: 1.61, 95%CI: 1.06-2.43) than those with normal levels. Further adjustment for subclinical inflammation did not substantially change the association between Vitamin D deficiency and HF.Deficiency of Vitamin D was associated, independently of known HF risk factors, with an increased risk of hospitalization for HF in an Italian adult population.
S. Costanzo; A. De Curtis; A. Di Castelnuovo; M. Persichillo; M. Bonaccio; G. Pounis; C. Cerletti; M.B. Donati; G. de Gaetano; L. Iacoviello; Jos Vermylen; Ignacio De Paula Carrasco; Simona Giampaoli; Antonio Spagnuolo; Deodato Assanelli; Vincenzo Centritto; Pasquale Spagnuolo; Dante Staniscia; Francesco Zito; Americo Bonanni; Roberto Lorenzet; Antonio Mascioli; Marco Olivieri; Domenico Rotilio; Francesco Gianfagna; Maurizio Giacci; Antonella Padulo; Dario Petraroia; Claudio Grippi; Sara Magnacca; Federico Marracino; Maria Spinelli; Christian Silvestri; Francesca De Lucia; Benedetta Izzi; Branislav Vohnout; Franco Zito; Angelita Verna; Maura Di Lillo; Irene Di Stefano; Agnieszka Pampuch; Agostino Pannichella; Antonio Rinaldo Vizzarri; Antonella Arcari; Daniela Barbato; Francesca Bracone; Carmine Di Giorgio; Simona Panebianco; Antonello Chiovitti; Sergio Caccamo; Vanesa Caruso; Livia Rago; Daniela Cugino; Alessandra Ferri; Concetta Castaldi; Marcella Mignogna; Tomasz Guszcz; Romina di Giuseppe; Paola Barisciano; Lorena Buonaccorsi; Floriana Centritto; Antonella Cutrone; Francesca Fanelli; Iolanda Santimone; Anna Sciarretta; Isabella Sorella; Emanuela Plescia; Alessandra Molinaro; Christiana Cavone; Giovanna Galuppo; Dolores D'Angelo; Rosanna Ramacciato. Serum vitamin D deficiency and risk of hospitalization for heart failure: Prospective results from the Moli-sani study. Nutrition, Metabolism and Cardiovascular Diseases 2018, 28, 298 -307.
AMA StyleS. Costanzo, A. De Curtis, A. Di Castelnuovo, M. Persichillo, M. Bonaccio, G. Pounis, C. Cerletti, M.B. Donati, G. de Gaetano, L. Iacoviello, Jos Vermylen, Ignacio De Paula Carrasco, Simona Giampaoli, Antonio Spagnuolo, Deodato Assanelli, Vincenzo Centritto, Pasquale Spagnuolo, Dante Staniscia, Francesco Zito, Americo Bonanni, Roberto Lorenzet, Antonio Mascioli, Marco Olivieri, Domenico Rotilio, Francesco Gianfagna, Maurizio Giacci, Antonella Padulo, Dario Petraroia, Claudio Grippi, Sara Magnacca, Federico Marracino, Maria Spinelli, Christian Silvestri, Francesca De Lucia, Benedetta Izzi, Branislav Vohnout, Franco Zito, Angelita Verna, Maura Di Lillo, Irene Di Stefano, Agnieszka Pampuch, Agostino Pannichella, Antonio Rinaldo Vizzarri, Antonella Arcari, Daniela Barbato, Francesca Bracone, Carmine Di Giorgio, Simona Panebianco, Antonello Chiovitti, Sergio Caccamo, Vanesa Caruso, Livia Rago, Daniela Cugino, Alessandra Ferri, Concetta Castaldi, Marcella Mignogna, Tomasz Guszcz, Romina di Giuseppe, Paola Barisciano, Lorena Buonaccorsi, Floriana Centritto, Antonella Cutrone, Francesca Fanelli, Iolanda Santimone, Anna Sciarretta, Isabella Sorella, Emanuela Plescia, Alessandra Molinaro, Christiana Cavone, Giovanna Galuppo, Dolores D'Angelo, Rosanna Ramacciato. Serum vitamin D deficiency and risk of hospitalization for heart failure: Prospective results from the Moli-sani study. Nutrition, Metabolism and Cardiovascular Diseases. 2018; 28 (3):298-307.
Chicago/Turabian StyleS. Costanzo; A. De Curtis; A. Di Castelnuovo; M. Persichillo; M. Bonaccio; G. Pounis; C. Cerletti; M.B. Donati; G. de Gaetano; L. Iacoviello; Jos Vermylen; Ignacio De Paula Carrasco; Simona Giampaoli; Antonio Spagnuolo; Deodato Assanelli; Vincenzo Centritto; Pasquale Spagnuolo; Dante Staniscia; Francesco Zito; Americo Bonanni; Roberto Lorenzet; Antonio Mascioli; Marco Olivieri; Domenico Rotilio; Francesco Gianfagna; Maurizio Giacci; Antonella Padulo; Dario Petraroia; Claudio Grippi; Sara Magnacca; Federico Marracino; Maria Spinelli; Christian Silvestri; Francesca De Lucia; Benedetta Izzi; Branislav Vohnout; Franco Zito; Angelita Verna; Maura Di Lillo; Irene Di Stefano; Agnieszka Pampuch; Agostino Pannichella; Antonio Rinaldo Vizzarri; Antonella Arcari; Daniela Barbato; Francesca Bracone; Carmine Di Giorgio; Simona Panebianco; Antonello Chiovitti; Sergio Caccamo; Vanesa Caruso; Livia Rago; Daniela Cugino; Alessandra Ferri; Concetta Castaldi; Marcella Mignogna; Tomasz Guszcz; Romina di Giuseppe; Paola Barisciano; Lorena Buonaccorsi; Floriana Centritto; Antonella Cutrone; Francesca Fanelli; Iolanda Santimone; Anna Sciarretta; Isabella Sorella; Emanuela Plescia; Alessandra Molinaro; Christiana Cavone; Giovanna Galuppo; Dolores D'Angelo; Rosanna Ramacciato. 2018. "Serum vitamin D deficiency and risk of hospitalization for heart failure: Prospective results from the Moli-sani study." Nutrition, Metabolism and Cardiovascular Diseases 28, no. 3: 298-307.
Platelet count varies by age, sex and ethnicity. However, previous studies have adopted standard ranges to identify subjects with thrombocytopenia or thrombocytosis. The aim of this study was to test the predictive role of age-sex-based cut-offs of platelet count proposed by an Italian collaborative study, towards the risk of cause-specific death. We conducted a prospective analysis on 21,563 adult subjects (mean age 55.6 ± 11.8) randomised from the general population of the Moli-sani study. Hazard ratios (HR) were calculated by multivariable Cox-proportional hazard models with 95% confidence intervals. Over a median follow-up of 8.2 years (interquartile range: 7.3 to 9.2 years; 175,972 person-years), we ascertained and validated 1,130 deaths, 415 of which are from cardiovascular disease, 439 from cancer and 276 from non-vascular/non-cancer causes. As opposed to the normal ranges defined by age and sex (extreme values from 122 to 405 x109/L), lower platelet number (87.7% of values being higher than 100x109/L) was associated with increased risk of total (HR = 1.92; 95%CI 1.38–2.67), cancer (HR = 1.77; 95%CI 1.03–3.05), and non-cardiovascular/non-cancer mortality (HR = 3.16; 95%CI 1.84–5.42) but was unrelated to cardiovascular mortality. Higher platelet count was not associated with any death risk. In conclusion, age-sex-based low platelet count, well above the traditional lower normal range of <100 x109/L, is associated with increased total and specific mortality risk in a general population.
Marialaura Bonaccio; Augusto Di Castelnuovo; Simona Costanzo; Amalia de Curtis; Maria Benedetta Donati; Chiara Cerletti; Giovanni de Gaetano; Licia Iacoviello. Age- and sex-based ranges of platelet count and cause-specific mortality risk in an adult general population: prospective findings from the Moli-sani study. Platelets 2017, 29, 312 -315.
AMA StyleMarialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Amalia de Curtis, Maria Benedetta Donati, Chiara Cerletti, Giovanni de Gaetano, Licia Iacoviello. Age- and sex-based ranges of platelet count and cause-specific mortality risk in an adult general population: prospective findings from the Moli-sani study. Platelets. 2017; 29 (3):312-315.
Chicago/Turabian StyleMarialaura Bonaccio; Augusto Di Castelnuovo; Simona Costanzo; Amalia de Curtis; Maria Benedetta Donati; Chiara Cerletti; Giovanni de Gaetano; Licia Iacoviello. 2017. "Age- and sex-based ranges of platelet count and cause-specific mortality risk in an adult general population: prospective findings from the Moli-sani study." Platelets 29, no. 3: 312-315.
Background To assess the association between health-related quality of life (HRQL) and a composite outcome including incident coronary heart disease (CHD) and cerebrovascular events in a large general population-based cohort. Design Prospective analysis on 17,102 men and women (mean age 53 ± 11) free from cardiovascular disease at time of enrolment in the Moli-sani cohort (2005–2010). Methods HRQL was assessed by the 36-Item Short Form Health Survey. Hazard ratios with 95% confidence intervals (95% CIs) were calculated using multivariable Cox-proportional hazard models. Results At the end of follow-up (median 4.2 years), 237 new events occurred (coronary heart disease n = 197, cerebrovascular disease n = 42). In a multivariable model adjusted for socioeconomic factors, chronic disease and health-related behaviours, both mental and physical HRQL were inversely associated with the risk of the composite outcome (hazard ratio = 0.57; 0.39–0.84 and hazard ratio = 0.62; 0.40–0.94, respectively; highest vs. lowest quartile). Further adjustment for C-reactive protein marginally modified the association with physical HRQL (hazard ratio = 0.67; 0.43–1.02). Similar findings were obtained when only CHD events were analysed (hazard ratio = 0.63; 0.41–0.96 for highest versus lowest mental HRQL) although results with physical HRQL were no longer significant (hazard ratio = 0.65; 0.40–1.04 for highest versus lowest quartile). Associations with incident cerebrovascular disease showed a trend toward protection (hazard ratio = 0.50; 0.22–1.17 and hazard ratio = 0.51; 0.22–1.23 for highest versus lowest tertile of mental and physical HRQL, respectively). Conclusions HRQL is an independent predictor of composite CHD/cerebrovascular outcomes in an adult population. The magnitude of the association was not affected either by socioeconomic factors, health conditions or health-related behaviours. Improvement of quality of life may be a major factor in targeting appropriate prevention strategies for cardiovascular health.
Marialaura Bonaccio; Augusto Di Castelnuovo; Simona Costanzo; Mariarosaria Persichillo; Amalia de Curtis; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello. Health-related quality of life and risk of composite coronary heart disease and cerebrovascular events in the Moli-sani study cohort. European Journal of Preventive Cardiology 2017, 25, 287 -297.
AMA StyleMarialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Mariarosaria Persichillo, Amalia de Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello. Health-related quality of life and risk of composite coronary heart disease and cerebrovascular events in the Moli-sani study cohort. European Journal of Preventive Cardiology. 2017; 25 (3):287-297.
Chicago/Turabian StyleMarialaura Bonaccio; Augusto Di Castelnuovo; Simona Costanzo; Mariarosaria Persichillo; Amalia de Curtis; Chiara Cerletti; Maria Benedetta Donati; Giovanni de Gaetano; Licia Iacoviello. 2017. "Health-related quality of life and risk of composite coronary heart disease and cerebrovascular events in the Moli-sani study cohort." European Journal of Preventive Cardiology 25, no. 3: 287-297.
There is lack of evidence about the likely impact of the economic crisis on dietary habits in Western societies. We aimed to assess dietary modifications that possibly occurred during the recession and to investigate major socioeconomic factors associated with such modifications. Cross-sectional analysis on 1829 subjects from the general population recruited in the larger INHES study (n = 9319) a telephone-based survey on nutrition and health conducted in Italy from 2010 to 2013. Association of socioeconomic (education, household income, occupation) with self-reported impact of the economic crisis on dietary habits was tested by multivariable logistic regression analysis. Low-educated subjects (OR = 2.30; 95% CI: 1.39-3.80), those with poor income (OR = 5.71; 95% CI: 3.68-8.85), and unemployed (OR = 3.93; 95% CI: 1.62-9.56) had higher odds of reporting undesirable dietary changes due to recession. Adherence to the Mediterranean diet was lower in subjects reporting a negative impact of the crisis on diet as compared to those declaring no effect, whereas the quality of grocery items was higher in the latter. Undesirable dietary changes due to the economic crisis were mainly reported by lower socioeconomic groups. Subjects perceiving a negative impact of the recession on their diet also showed a lower adherence to Mediterranean diet and reduced quality of grocery products.
Marialaura Bonaccio; Augusto Di Castelnuovo; Americo Bonanni; Simona Costanzo; Mariarosaria Persichillo; Chiara Cerletti; Maria Benedetta Donati; Giovanni De Gaetano; Licia Iacoviello; INHES Study Investigators. Socioeconomic status and impact of the economic crisis on dietary habits in Italy: results from the INHES study. Journal Of Public Health 2017, 40, 703 -712.
AMA StyleMarialaura Bonaccio, Augusto Di Castelnuovo, Americo Bonanni, Simona Costanzo, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni De Gaetano, Licia Iacoviello, INHES Study Investigators. Socioeconomic status and impact of the economic crisis on dietary habits in Italy: results from the INHES study. Journal Of Public Health. 2017; 40 (4):703-712.
Chicago/Turabian StyleMarialaura Bonaccio; Augusto Di Castelnuovo; Americo Bonanni; Simona Costanzo; Mariarosaria Persichillo; Chiara Cerletti; Maria Benedetta Donati; Giovanni De Gaetano; Licia Iacoviello; INHES Study Investigators. 2017. "Socioeconomic status and impact of the economic crisis on dietary habits in Italy: results from the INHES study." Journal Of Public Health 40, no. 4: 703-712.
Neuromedin U (NmU) is a pleiotropic hypothalamic neuropeptide involved in the gut-brain axis. It acts via both a Gαq/11-coupled receptor (NMUR1) and a Gαi-coupled receptor (NMUR2) in different cell types. Expression of both receptors was reported in platelets, but their significance for NmU signaling remains elusive. We studied the potential effects of NmU on human platelet activation. In platelet-rich plasma (PRP), NmU alone (up to 10μM) did not induce any measurable aggregation, but at nanomolar concentrations, it potentiated platelet aggregation by low (mean 0.47μM) ADP concentrations (from 25.9±3.6% to 74.8±2.7% maximal aggregation for ADP vs. ADP+NmU, 100nM, mean±SEM, n=13), accompanied by platelet P-selectin expression and intracellular calcium mobilization. Accordingly, platelet preincubation with NmU for 2min sensitized platelets for subsequent activation by ADP. When P2Y1 was inactivated by 50μM MRS2179, NmU comparably potentiated ADP-induced PRP aggregation, suggestive of cooperative activation with Gαi-coupled P2Y12. Likewise, NmU potentiated platelet aggregation by Gαi-operated epinephrine at subthreshold concentrations (99ng/ml, mean), but not that by Gαq-dependent serotonin (20μM). Platelet aggregation by NmU/epinephrine combination was fully inhibited by the Gαq inhibitor YM-254890 (1μM). qPCR detection and western blot analysis substantiated platelet expression of NMUR1 in different donors, a finding collectively complying with functionally relevant Gαq/11-mediated activation of platelet NMUR1 by NmU. Our findings advocate further studies on platelet sensitization by NmU, released during vascular activation and injury, to define its role as a modifier of platelet responsiveness to the physiological activation signals, operational in cardiovascular health and disease.
C. Grippi; Benedetta Izzi; F. Gianfagna; F. Noro; E. Falcinelli; A. Di Pardo; E. Amico; M.B. Donati; G. de Gaetano; Licia Iacoviello; M.F. Hoylaerts; C. Cerletti. Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation. Thrombosis Research 2017, 159, 100 -108.
AMA StyleC. Grippi, Benedetta Izzi, F. Gianfagna, F. Noro, E. Falcinelli, A. Di Pardo, E. Amico, M.B. Donati, G. de Gaetano, Licia Iacoviello, M.F. Hoylaerts, C. Cerletti. Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation. Thrombosis Research. 2017; 159 ():100-108.
Chicago/Turabian StyleC. Grippi; Benedetta Izzi; F. Gianfagna; F. Noro; E. Falcinelli; A. Di Pardo; E. Amico; M.B. Donati; G. de Gaetano; Licia Iacoviello; M.F. Hoylaerts; C. Cerletti. 2017. "Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation." Thrombosis Research 159, no. : 100-108.