Human activities both aggravate and alleviate streamflow drought. Here we show that aggravation is dominant in contrasting cases around the world analysed with a consistent methodology. Our 28 cases included different combinations of human-water interactions. We found that water abstraction aggravated all drought characteristics, with increases of 20%–305% in total time in drought found across the case studies, and increases in total deficit of up to almost 3000%. Water transfers reduced drought time and deficit by up to 97%. In cases with both abstraction and water transfers into the catchment or augmenting streamflow from groundwater, the water inputs could not compensate for the aggravation of droughts due to abstraction and only shift the effects in space or time. Reservoir releases for downstream water use alleviated droughts in the dry season, but also led to deficits in the wet season by changing flow seasonality. This led to minor changes in average drought duration (−26 to +38%) and moderate changes in average drought deficit (−86 to +369%). Land use showed a smaller impact on streamflow drought, also with both increases and decreases observed (−48 to +98%). Sewage return flows and pipe leakage possibly counteracted the effects of increased imperviousness in urban areas; however, untangling the effects of land use change on streamflow drought is challenging. This synthesis of diverse global cases highlights the complexity of the human influence on streamflow drought and the added value of empirical comparative studies. Results indicate both intended and unintended consequences of water management and infrastructure on downstream society and ecosystems.

Human-induced warming is modifying the water cycle. Adaptation to posed threats requires an understanding of hydrological responses to climate variability. Whilst these can be computationally modelled, observed streamflow data is essential for constraining models, and understanding and quantifying emerging trends in the water cycle. To date, the identification of such trends at the global scale has been hindered by data limitations – in particular, the prevalence of direct human influences on streamflow which can obscure climate-driven variability. By removing these influences, trends in streamflow data can be more confidently attributed to climate variability. Here we describe the Reference Observatory of Basins for INternational hydrological climate change detection (ROBIN) – the first iteration of a global network of streamflow data from national reference hydrological networks (RHNs) – comprised of catchments which are near-natural or have limited human influences. This collaboration has established a freely available global RHN dataset of over 3,000 catchments and code libraries, which can be used to underpin new science endeavours and advance change detection studies to support international climate policy and adaptation.