Gal Reddy Potuganti

Dr. Gal Reddy Potuganti

Arizona State University, Tempe, Arizona, USA
orcid

Research Focus & Metrics

Academic Career Length

9Years (2018-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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12 June 2019 in Synlett
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DIDivakar Reddy Indukuri
Divakar Reddy Indukuri
GPGal Reddy Potuganti
Gal Reddy Potuganti
MAManjula Alla
Manjula Alla
A facile, rapid, metal-free regioselective halogenation and thiocyanation of imidazo[1,2-a]pyridine/pyrimidine heterocycles has been achieved under solvent-free reaction conditions. Halogenations and thiocyanation of the heterocycles could be accomplished by simple grinding of reactants and hypervalent iodine reagents with the corresponding alkali metal or ammonium salts. The method has been extrapolated to a cleaner synthesis of brominated imidazo[1,2-a]pyridine/pyrimidine derivatives, starting from the corresponding heterocyclic amines and substituted α-bromoketones, utilising HBr generated in situ as the source of bromine.

22 November 2018 in The Journal of Organic Chemistry
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Journal Article
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GPGal Reddy Potuganti
Gal Reddy Potuganti
DIDivakar Reddy Indukuri
Divakar Reddy Indukuri
JNJagadeesh Babu Nanubolu
Jagadeesh Babu Nanubolu
MAManjula Alla
Manjula Alla

9 March 2026 in RSC Advances
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Journal Article
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SMShweta Mishra
Shweta Mishra
CJChetna Jadala
Chetna Jadala
SCSavio Cardoza
Savio Cardoza
GPGal Reddy Potuganti
Gal Reddy Potuganti
GANGA REDDY VELMAGANGA REDDY VELMA
GANGA REDDY VELMA
Fluorine has been widely incorporated into small-molecule drugs as an effective strategy to modulate metabolic stability, lipophilicity, target interactions, and overall pharmacokinetic profile.

3 August 2021 in Communications Chemistry
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RKRajnandani Kashyap
Rajnandani Kashyap
NYNaga Veera Yerra
Naga Veera Yerra
JOJoachyutharayalu Oja
Joachyutharayalu Oja
SBSandeepchowdary Bala
Sandeepchowdary Bala
GPGal Reddy Potuganti
Gal Reddy Potuganti
AAAnthony Addlagatta
Anthony Addlagatta
The 100-year-old Diels–Alder reaction (DAr) is an atom economic and elegant organic chemistry transformation combining a 1,3-diene and a dienophile in a [4+2] cycloaddition leading to a set of products with several stereo centres and multiple stereoisomers. Stereoselective [4+2] cycloaddition is a challenge. Here, we describe two natural enzymes, PyrI4 and AbnU performing stereospecific intermolecular DAr on non-natural substrates. AbnU catalyses a single exo-stereoisomer by 32-fold higher than the background. PyrI4 catalyses the same stereoisomer (15-fold higher) as a major component (>50%). Structural, biochemical and fluorescence studies indicate that the dienophile enters first into the β-barrel of the enzymes followed by the 1,3-diene, yielding a stereospecific product. However, if some critical interactions are disrupted to increase the catalytic efficiency, stereoselectivity is compromised. Since it is established that natural enzymes can carry out intermolecular DAr on non-natural substrates, several hundreds of Diels-Alderases available in nature could be explored.

24 April 2026 in RSC Advances
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Journal Article
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CJChetna Jadala
Chetna Jadala
SMShweta Mishra
Shweta Mishra
GPGal Reddy Potuganti
Gal Reddy Potuganti
SCSavio Cardoza
Savio Cardoza
GANGA REDDY VELMAGANGA REDDY VELMA
GANGA REDDY VELMA
Nitrogen-containing heterocycles (N-Hets) are among the most prevalent and versatile structural motifs in pharmaceuticals, serving as key scaffolds in over 85% of biologically active small molecules.

4 May 2018 in Synlett
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Journal Article
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MAManjula Alla
Manjula Alla
GPGal Reddy Potuganti
Gal Reddy Potuganti
DIDivakar Reddy Indukuri
Divakar Reddy Indukuri
An efficient one-pot synthesis of quinazolino[4,3-b]quinazoline derivatives has been accomplished, starting from 2-(2-bromo­phenyl)quinazolin-4(3H)-one, aldehydes, and various nitrogen sources under aerobic conditions. The multicomponent protocol is mediated by copper(I) salts and involves amination of 2-(2-bromophenyl)quinazolin-4(3H)-one, followed by condensation with the aldehyde and an oxidative cyclization to give the target compounds in moderate to good yields.