In recent years, the usage of radio frequency magnetic fields for biomedical applications has increased exponentially. Several diagnostic and therapeutic methodologies exploit this physical entity such as, for instance, magnetic resonance imaging, hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation. Within this framework, the magnetic field focusing and shaping, at different depths inside the tissue, emerges as one of the most important challenges from a technological point of view, since it is highly desirable for improving the effectiveness of clinical methodologies. In this review paper, we will first report some of the biomedical practices employing radio frequency magnetic fields, that appear most promising in clinical settings, explaining the underneath physical principles and operative procedures. Specifically, we direct the interest toward hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation, together with a brief mention of magnetic resonance imaging. Additionally, we deeply review the technological solutions that have appeared so far in the literature to shape and control the radio frequency magnetic field distribution within biological tissues, highlighting human applications. In particular, volume and surface coils, together with the recent raise of metamaterials and metasurfaces will be reported. The present review manuscript can be useful to fill the actual gap in the literature and to serve as a guide for the physicians and engineers working in these fields.

In this paper, we present a novel passive dual-tuned magnetic metasurface, which can enhance the field distribution produced by a closely placed radio-frequency coil for both ¹H and ²³Na 1.5 T MRI imaging. In particular, the proposed solution comprises a 5 × 5 capacitively loaded array, in which each unit-cell is composed of two concentric spiral coils. Specifically, the unit-cell internal spiral coil operates at the proton Larmor frequency (64 MHz), whereas the external is at the sodium one (17 MHz). Therefore, the paper aims to demonstrate the possibility of enhancing the magnetic field distribution in transmission and reception for 1.5 T MRI scanners by using the same metasurface configuration for imaging both nuclei, thus drastically simplifying the required instrumentation. We first describe the theoretical model used to design and synthetize the dual-tuned magnetic metasurface. Next, full-wave simulations are carried out to validate the approach. Finally, we report the experimental results acquired by testing the fabricated prototype at the workbench, observing a good agreement with the theoretical design and the numerical simulations. In particular, the metasurface increases the transmission efficiency T_x in presence of a biological phantom by a factor 3.5 at 17 MHz and by a factor 5 at 64 MHz, respectively. The proposed solution can pave the way for MRI multi-nuclei diagnostic technique with better images quality, simultaneously reducing the scanning time, the invasiveness on the patient and the overall costs.

In this study, we present a wearable sensing system for monitoring the physiological status of damaged biological tissues based on a flexible, frequency-coded electromagnetic spiral resonator array. The physiological parameter evaluation is performed in a contactless way, avoiding the placing of electronically active elements directly upon the patient’s skin, thus ensuring safety and comfort. Firstly, we report in detail the physical principles behind the sensing strategy: a passive array is interrogated through an actively fed external single-loop probe that is inductively coupled with the double-layer spiral unit cells. The variation in the physiological parameters influences the array response, thus providing sensing information, due to the different complex dielectric permittivity values related to the tissue status. Moreover, the proposed frequency-coded approach allows for spatial information on the lesion to be retrieved, thus increasing the sensing ability. In order to prove the validity of this general methodology, we created a numerical test case, designing a practical implementation of the wearable sensing system working at a radiofrequency regime (10–100 MHz). In addition, we also fabricated prototypes, exploiting PCB technology, and realized stratified phantoms by incorporating opportune additives to control the dielectric properties. The numerical results and the experimental verification demonstrated the validity of the developed sensing strategy, showing satisfying agreement and, thus, proving the good sensibility and spatial resolution of the frequency-coded array. These results can open the path to a radically novel approach for self-care and monitoring of inflamed status and, more generally, for wearable sensing devices in biomedical applications.

In this article, the theoretical and experimental feasibility analyses of a high-sensitivity imaging system for non-invasive detection of pathological inclusions within biological tissues are presented. The radiating system, exploiting a low frequency magnetic field operating at 3 MHz, consists of an inner resonant spiral sensor, inductively coupled to an unloaded external planar probe loop. The proposed configuration produces a focused magnetic field distribution, therefore a high-sensitivity imaging with respect to the wavelength can be accomplished (detecting inclusions with size in the order of λ/10000, i.e., 1 cm). In particular, the inclusion detection is carried out by observing the amplitude shift of the external probe loop input impedance while scanning the region of interest, leading to a non-invasive and contactless imaging procedure. In addition, we demonstrate the possibility to detect an inclusion, placed within the investigated tissue, either with or without the use of a ferromagnetic contrast medium. To evaluate the proposed imaging system effectiveness, we first perform full-wave numerical simulations. Then, we report the experimental measurements acquired over a fabricated prototype interacting with a representative biological phantom, observing a very good agreement with the numerical simulations. The results confirm the potential for an innovative near-field imaging system to be employed for non-invasive detection of malignant inclusions, expanding the adoption of low RF frequencies in biomedical applications.