Natural wetlands are among the most important sources of atmospheric methane and thus important for better understanding the long-term temporal variations in the atmospheric methane concentration. During the last 60 years, wetlands have experienced extensive conversion and impacts from climate warming which might result in complicated temporal and spatial variations in the changes of the wetland methane emissions. In this paper, we present a modeling framework, integrating CH4MOD wetland , TOPMODEL, and TEM models, to analyze the temporal and spatial variations in CH 4 emissions from natural wetlands (including inland marshes/swamps, coastal wetlands, lakes, and rivers) in China. Our analysis revealed a total increase of 25.5 %, averaging 0.52 g m −2 per decade, in the national CH 4 fluxes from 1950 to 2010, which was mainly induced by climate warming. Larger CH 4 flux increases occurred in northeastern, northern, and northwestern China, where there have been higher temperature rises. However, decreases in precipitation due to climate warming offset the increment of CH 4 fluxes in these regions. The CH 4 fluxes from the wetland on the Qinghai–Tibet Plateau exhibited the lowest CH 4 increase (0.17 g m −2 per decade). Although climate warming has accelerated CH 4 fluxes, the total amount of national CH 4 emissions decreased by approximately 2.35 Tg (1.91–2.81 Tg), i.e., from 4.50 Tg in the early 1950s to 2.15 Tg in the late 2000s, due to the wetland loss totalling 17.0 million ha. Of this reduction, 0.26 Tg (0.24–0.28 Tg) was derived from lakes and rivers, 0.16 Tg (0.13–0.20 Tg) from coastal wetlands, and 1.92 Tg (1.54–2.33 Tg) from inland wetlands. Spatially, northeastern China contributed the most to the total reduction, with a loss of 1.68 Tg. The wetland CH 4 emissions reduced by more than half in most regions in China except for the Qinghai–Tibet Plateau, where the CH 4 decrease was only 23.3 %.