The increasing demand for low-cost space-borne Earth observation missions has led to small satellite constellation systems development. CubeSat platforms can provide a cost-effective multiple-mission space system using state-of-the-art technology. This paper presents a new approach to CubeSat constellation design for multiple missions using a multi-objective genetic algorithm (MOGA). The CubeSat constellation system is proposed to perform multi-missions that should satisfy global Earth observation and regional disaster monitoring missions. A computational approach using a class of MOGA named non-dominated sorting genetic algorithm II is implemented to optimize the proposed system. Pareto optimal solutions are found that can minimize the number of satellites and the average revisit time (ART) for both regional and global coverage while maximizing the percentage coverage. As a result, the study validates the feasibility of implementing the CubeSat constellation design with an acceptable level of performance in terms of ART and percentage coverage. Moreover, the study demonstrates CubeSat’s ability to perform a multi-missions.