Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness. The application of coformers in a multicomponent crystal method is one possible strategy to modulate a drug’s solubility. A multicomponent crystal is a solid phase formed when several molecules of different substances crystallize in a crystal lattice with a certain stoichiometric ratio. The goal of this review paper is to comprehensively describe the application of coformers in the formation of multicomponent crystals as solutions for pharmaceutically active ingredients with limited solubility. Owing to their benefits including improved physicochemical profile of pharmaceutically active ingredients, multicomponent crystal methods are predicted to become increasingly prevalent in the development of active drug ingredients in the future

Cold Chain Products are pharmaceutical preparations sensitive to temperature, requiring consistently maintained temperature conditions from production, storage, and transportation to the final consumer. Environmental changes, such as temperature fluctuations and direct sunlight exposure, can reduce product quality, leading to the loss of the product's therapeutic potential. Therefore, Pedagang Besar Farmasi (PBF) play a crucial role throughout the distribution chain of cold chain products to ensure that the quality and effectiveness of the products are maintained. This study aims to evaluate the implementation of cold chain product management at a PBF in Tasikmalaya City according to the applicable guidelines, namely the Good Distribution Practices (CDOB). The study employs observation and interview methods, with evaluation using a research tool in the form of a checklist developed based on aspects of cold chain product management according to the 2020 CDOB guidelines. Based on the evaluation of cold chain product management implementation according to CDOB, a PBF in Tasikmalaya City has successfully implemented CDOB aspects well.