Six benzenesulfonylhydrazone derivatives of methyl dehydroabietate are synthesized via esterification, benzylic oxidation, condensation with hydrazine hydrate, and following nucleophilic substitution...

The 7-C₆₀-adduct of N,N-(tetrachlorophthaloyl)dehydroabietylamine was synthesized for the first time and characterized by IR, UV-vis, mass and NMR spectral studies. The ¹H-NMR and ¹³C-NMR resonance signals of the new compound are unambiguously assigned by using homo- and heteronuclear 2D NMR spectroscopic techniques such as COSY, ROESY, HSQC and HMBC. The C₁ symmetric structure with 6,6-junction of compound was determined.

Senven new acylhydrazone derivatives of dehydroabietic acid were synthesized from dehydroabietic acid through benzylic oxidation, condensation with hydrazine hydrate, followed by nucleophilic substitution reactions with a variety of substituted aromatic acids. The structures of the synthesized compounds were characterized by IR、1H NMR、MS. The antibacterial activities of the synthesized compounds were evaluated by disk diffusion method. Antibacterial activities studies showed that acylhydrazone derivatives of dehydroabietic acid exhibited inhibitory activities against E. coli, S. aureus and B. subtilis. Among the senven compounds, dehydroabietic acid p-fluorobenzoyl hydrazone showed the strongest inhibitory activity against B. subtilis and S. aureus, the diameters of antibacterial rings reached 1.68 and 1.45 cm, respectively.