Progesterone plays an important role in initial conceptus development and in a successful pregnancy, but results related to progesterone or its analogues (altrenogest) supplementation in early pregnancy of pigs are conflicting. The present study evaluated the effects of altrenogest supplementation in sows during days 6 and 12 of pregnancy on reproductive performance. On day 6 of pregnancy, 301 females were allocated at random to one of the following treatments: CON (Control: non-supplemented females, n = 163) or ALT (females daily supplemented with 20 mg of altrenogest, orally, from day 6 to 12 of pregnancy, n = 138). Ovulation was considered as occurred at 48 h after the first estrus detection to standardize the first day of pregnancy. The supplementation increased the number of total piglets born (ALT: 17.3 ± 0.4; CON: 16.6 ± 0.4), piglets born alive (ALT: 15.6 ± 0.4; CON: 14.8 ± 0.3), and placenta weight (ALT: 4.2 ± 0.1; CON: 3.8 ± 0.1) and decreased the stillbirth rate (ALT: 5.9 ± 0.6; CON: 7.6 ± 0.6) and the number of piglets born weighing less than 800 g (ALT: 6.6 ± 0.6; CON: 8.0 ± 0.6), without impairment on farrowing rate. These results demonstrated that altrenogest supplementation on swine females between days 6 and 12 of pregnancy may be used to improve reproductive performance.

This study evaluated the effects of graded dietary barley malt extract (BME) supplementation on growth performance, fecal consistency, immune parameters, antioxidant status, short-chain fatty acid (SCFA) concentrations, and gut microbiota composition in nursery piglets. A total of 144 weaned piglets (24 days of age; 7.02 ± 1.08 kg) were allocated to four treatments containing 0, 0.33, 0.66, or 0.99% BME for 42 days. Performance variables were assessed at the pen level, and laboratory analyses were performed using one representative piglet per selected pen. No consistent dose–response effects were observed for body weight, average daily gain, feed intake, or diarrhea incidence throughout the nursery period. A linear increase in feed conversion ratio was detected during the pre-starter II phase ( P = 0.023), but no cumulative performance effects were observed over the overall nursery period. Antioxidant enzyme activities, leukocyte populations, and fecal SCFA concentrations were unaffected by BME inclusion ( P > 0.05). Microbial alpha diversity indices were unchanged; however, specific microbial taxa, including Veillonellaceae, Mitsuokella , and Mogibacterium , differed among inclusion levels. Overall, dietary BME up to 0.99% did not improve growth performance, immune parameters, antioxidant status, or intestinal fermentation in nursery piglets, although modest shifts in microbial composition were observed.

This study evaluated the performance of gestating and lactating sows supplemented with tributyrin from gestation until the end of lactation. Additionally, it assessed the effects of this supplementation on pig growth performance during the nursery phase. A total of 148 commercial-line sows (DB90 Brasil; parity 1–4; initial weight: 201.7 ± 12.2 kg) were used during gestation and lactation, along with 180 weaned pigs. A randomized block design was utilized with two dietary treatments during gestation and lactation, and a 2 × 2 factorial arrangement during the nursery phase. Data on sow body composition and productivity during gestation and lactation, as well as piglet performance during nursery, were collected. Treatment effects and interactions were analyzed using ANOVA with the MIXED procedure of SAS Version 9.0 (SAS Inst. Inc., Cary, NC, USA). Sows fed tributyrin tended to weigh 3.05 kg more (p = 0.053) and had 6.51% less backfat accumulation prepartum (p = 0.099). Supplementation reduced stillborns by 35.47% (p = 0.032) and increased litter weight at birth by 10.14% (p = 0.018). Additionally, there was a trend toward an 18.73% reduction in weight variability (p = 0.053) with more piglets weighing ≥1.4 kg. Sow and litter performance during lactation were not affected. Piglets from sows supplemented with tributyrin showed a trend for higher feed intake immediately post-weaning (p = 0.056). Tributyrin supplementation during gestation reduced stillborn rates and increased litter weight at birth.