Cancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis and treatment. Most CTAs are located on the X chromosome and aggregate into large gene families, such as the melanoma antigen, synovial sarcoma X and G antigen families. Members of the CTA subfamily are usually co‑expressed in tumor tissues and share similar structural characteristics and biological functions. As cancer vaccines are recommended to induce specific antitumor responses, CTAs, particularly CTA subfamilies, are widely used in the design of cancer vaccines. To date, DNA, mRNA and peptide vaccines have been commonly used to generate tumor‑specific CTAs in vivo and induce anticancer effects. Despite promising results in preclinical studies, the antitumor efficacy of CTA‑based vaccines is limited in clinical trials, which may be partially attributed to weak immunogenicity, low efficacy of antigen delivery and presentation processes, as well as a suppressive immune microenvironment. Recently, the development of nanomaterials has enhanced the cancer vaccination cascade, improved the antitumor performance and reduced off‑target effects. The present study provided an in‑depth review of the structural characteristics and biofunctions of the CTA subfamilies, summarised the design and utilisation of CTA‑based vaccine platforms and provided recommendations for developing nanomaterial‑derived CTA‑targeted vaccines.

Walking-induced vibration control in wood floors is a critical issue attracting the attention of many researchers and engineers. This paper presents an experimental study applying static deflection tests, modal tests, and pedestrian load tests to a series of full-scale 12 m span tooth plates connected to wood truss joist floors with strongbacks and partition walls. A comparison of the calculation error of vibration parameters between the theoretical formula and a numerical model was also conducted. The results show that strongbacks and partition walls effectively reduce both the vertical displacement and the root means acceleration at the center of the floor under pedestrian load but increases the natural frequency. The partition wall can achieve a better vibration-reduction effect than strongbacks. The error of the finite element model is higher than that of the theoretical formula. Using the theoretical formula in engineering wood floor design is recommended.