D. Rigante was born in 1966 and started his medical studies in 1986. He works in the field of hereditary periodic fevers at the Università Cattolica Sacro Cuore, Rome, Italy. His research activities have been focused on the study of autoinflammation and hereditary periodic fevers (epidemiologic as well as therapeutic issues of familial Mediterranean fever, mevalonate kinase deficiency syndrome, cryopyrin-associated periodic syndrome and Behçet’s disease). He has contributed to the creation of the first international registry for antiphospholipid syndrome in the pediatric age range, to the creation of the first international registry on P.F.A.P.A. syndrome, to the international analytical study about vasculitic syndromes of infancy, to the first epidemiologic study of uveitis associated with juvenile idiopathic arthritis, and to the creation of the first international registry about atypical and incomplete variants of Kawasaki disease. He has also contributed to the (i) definition of Italian guidelines for the management of Kawasaki disease, (ii) definition of international guidelines on diagnosis and management of childhood Behçet’s disease, (iii) general management of children with P.F.A.P.A. syndrome, and (iv) clinical trials related to the use of biologic drugs for the management of children with drug-refractory autoinflammatory syndromes.