Water is one of the most important natural resources and is widely used around the globe for various purposes. In fact, the agricultural sector consumes 70% of the world’s accessible water, of which about 60% is wasted. Thus, it needs to be managed scientifically and efficiently to maximize food production to meet the requirements of an ever-increasing population. There is a lack of information on water requirements of crops and irrigation scheduling concerning the Shaheed Benazirabad district, Pakistan. Thus, the present study was conducted to determine the irrigation water requirements (IWR) and irrigation scheduling for the major crops in the Shaheed Benazirabad district, Sindh, Pakistan, using agro-climatic data and the CROPWAT model. Agro-climatic data such as rainfall, maximum and minimum temperature, sunshine hours, humidity, and wind speed were obtained from the NASA website, CLIMWAT 2.0, and world weather However, data about studied crops and soils were obtained from FAO (Food and Agriculture Organization). Analysis revealed that the IWRs per irrigation round for the four major crops—sugarcane, banana, cotton, and wheat—were as 3108.0 mm, 1768.5 mm, 1655.7 mm, and 402.5 mm, respectively. It was observed the IWRs are more sensitive in the hot season because of high temperatures and low relative humidity, and vice versa in the cold season. The use of scientific tools such as CROPWAT is recommended to assess IWRs with a high degree of accuracy and to compute irrigation scheduling. Accordingly, the study results will be helpful for improving food production and supervision of water resources.