The aim of this study was to examine the association between type 2 diabetes (T2DM), use of glucose-lowering medications and endometrial cancer (EC) risk. Methods: The risk of EC incidence among women with T2DM in Lithuania was assessed using a retrospective cohort study design. Female patients who were registered with T2DM between 1 January 2000 and 31 December 2012 were identified in the National Health Insurance Fund database. EC cases (ICD-10 code C54) were identified from the Lithuanian Cancer Registry. Standardized incidence ratios (SIRs) were calculated by dividing the observed numbers of EC among patients with T2DM by the expected number of EC, calculated using national rates. Results: A total of 77,708 diabetic women were included in the analysis, and 995 cases of EC were identified. A significantly increased EC risk in diabetic women was found as compared to the general population (SIR = 1.69, 95% CI 1.59–1.80). The greatest EC risk was found among younger patients at T2DM diagnosis, and the risk declined gradually with increasing age but persisted in being significantly increased among all age groups. The risk for EC increased with increasing duration of diabetes, and the highest EC risk was observed more than 10 years after T2DM diagnosis. A significantly higher EC risk than expected from the general population was found in all patient groups by glucose-lowering medication combinations. The lowest EC risk was observed in diabetic women who were users of “oral only” (without metformin) (SIR = 1.42, 95% CI 1.10–1.83) and “metformin only” (SIR = 1.69, 95% CI 1.49–1.92) medications. A two times greater EC risk was observed among the remaining glucose-lowering medication categories. In contrast, use of insulin only was not related to a higher EC incidence risk (SIR = 0.45, 95% CI 0.23–0.86); however, the risk estimation was based on nine cases. Conclusions: Our study shows a significantly increased EC risk in diabetic women as compared to the general population. In this study, a significantly higher EC risk was found in all patient groups by glucose-lowering medication combinations, except for insulin only users.

In the light of the changing pattern of the consumption of dietary supplements among adults in other countries during the COVID-19 pandemic, we aim to assess the prevalence of the consumption of dietary supplements with respect to the purpose of consumption and sociodemographic factors among adults in Lithuania. This study included two samples of adults from Lithuania: 870 in 2019 and 1600 in 2021. Anonymous original questionnaires were used to collect the data about the consumption of dietary supplements before and during the pandemic. The consumption of dietary supplements was prevalent among 67.2% and 78.1% of the samples, respectively. Although the majority (73.7%) of the respondents indicated that the pandemic had no effect on their use of dietary supplements, every fourth respondent’s (24.6%) consumption increased. In 2021, the consumption was more prevalent among females, respondents with university education, urban citizens, employed respondents, respondents without children, with higher income, and those who knew a person with COVID-19 (p < 0.05). During the pandemic, the strengthening of the immune system and the body were the leading reasons for consumption (49.0% and 43.5%, respectively). The consumption of dietary supplements appropriate for these purposes increased among 63.3% and 66.9% of respondents, respectively. To conclude, the consumption of dietary supplements among adults in Lithuania increased during the COVID-19 pandemic.

Background: Pancreatic cancer is one of the deadliest cancers worldwide, and its incidence is increasing. The aim of this study was to examine the time trends in the incidence and mortality rates of pancreatic cancer for the period of 1998–2015 for the first time in Lithuania by sex, age, subsite, and stage. Methods: This study was based on all cases (deaths) of pancreatic cancer diagnosed between 1998 and 2015. Age-standardized incidence (mortality) rates and group-specific rates were calculated for each sex using the direct method (European Standard). TNM classification-based information reported to the cancer registry was grouped into three categories: (1) localized cancer: T1-3/N0/M0; (2) cancer with regional metastasis: any 1-3/N+/M0; (3) advanced cancer: any T/any N/M+. Joinpoint regression was used to provide annual percentage changes (APCs) and to detect points in time where statistically significant changes in the trends occurred. Results: Overall, 8514 pancreatic cancer cases (4364 in men and 3150 in women) were diagnosed and 7684 persons died from cancer of the pancreas. Pancreatic cancer incidence rates were considerably lower for women than for men, with a female:male ratio of 1:2. Incidence rates changed during the study period from 14.2 in 1998 to 15.0/100,000 in the year 2015 in men, and from 6.7 to 9.8/100,000 in women. Incidence rates over the study period were stable for men (APC = 0.1%) and increasing for women by 1.1% per year. Similarly, mortality rates increased in women by 0.9% per year, and were stable in men. During the study period, incidence and mortality rates of pancreatic cancer were close. For the entire study period, rates increased significantly in the 50–74 years age group; only cancer of the head of pancreas showed a decline by 0.9%, while tail and not-specified pancreatic cancer incidence increased by 11.4% and 4.51%, respectively. Conclusions: The increasing pancreatic cancer incidence trend in the Lithuanian population may be related to the prevalence of its main risk factors (smoking, obesity, physical inactivity, diet, and diabetes).

Background and Objectives: The aim of this study was to assess the consumption of dietary supplements (DS) among working-age residents of Lithuania from 2021 to 2023 with respect to social and demographic factors and an assessment of personal health. Materials and Methods: Using stratified sampling techniques, this study included three samples of working-age residents (1600 each year, 4800 total). Three surveys were conducted, the distribution of the respondents between groups was compared using the χ² test. Results: The consumption of DS significantly differed each year and accounted for 78.1%, 71.6%, and 72.7% of the respondents, respectively (p < 0.05). In 2022, the prevalence of the consumption of DS was lower in the majority of social and demographic groups (p < 0.05). In 2023, it was higher among females, younger residents, and those from larger families, who suffered from COVID-19 (p < 0.05). Despite similar changes found in the consumption of DS among those who negatively assessed their health, this group showed more prevalent consumption of DS among residents with non-university education, unemployed respondents, and those with lower income (p < 0.05). Conclusions: Despite a significantly lower prevalence in the consumption of DS in 2022, it was higher again in 2023. The assessment of personal health shows different habits in the consumption of DS.

Background: There is an insufficient level of research carried on the consumption of dietary supplements among diverse social and demographic groups, especially among those with a negative assessment of personal health. Therefore, the aim of this study was to assess the consumption of dietary supplements among working-age residents of Lithuania in the period from 2021 to 2023 with respect to social and demographic factors and the assessment of personal health. Materials and methods: The data for this study were collected after conducting three independent cross-sectional surveys in 2021, in 2022, and in 2023. Each of the samples included 1600 working-age adult residents of Lithuania. Distribution of the respondents by the assessment of personal health and gender, age, marital status, education level, place of residence, employment, income, and COVID-19 cases among the respondents and members of their families was assessed. Results: The consumption of dietary supplements differed each year and accounted for 78.1%, 71.6%, and 72.7% of the respondents, respectively (p < 0.05). In 2022, the prevalence of the consumption of dietary supplements was lower in the majority of social and demographic groups (p < 0.05). In 2023, it was higher among females, younger residents, and those from larger families, who suffered from COVID-19 (p < 0.05). Despite similar changes found in the consumption of dietary supplements among those who negatively assessed their health, this group showed more prevalent consumption of dietary supplements among residents with non-university education, unemployed respondents, and those with lower income (p < 0.05). Conclusions: Despite a significantly lower prevalence in the consumption of dietary supplements in 2022, it was higher again in 2023. A negative assessment of personal health is associated with opposite tendencies in the prevalence of the consumption of dietary supplements in the general population. Key messages: • Despite a significantly lower prevalence in the consumption of dietary supplements in 2022, it was higher again in 2023. • The negative assessment of personal health should be taken into account when planning nutritional interventions due to its association with different consumption of dietary supplements.

Background and Objectives: The COVID-19 pandemic had a significant impact on physical activity among various populations. Due to a lack of country-representative studies on the prevailing trends in leisure-time physical activity since the COVID-19 pandemic, the aim of this study was to assess the temporal, social, and demographic inequalities in the prevalence of engagement in exercise and sports among working-age citizens of Lithuania from 2021 to 2024. Materials and Methods: This study included four samples of working-age citizens (1600 per year, 6400 in total). Four surveys were conducted, and the distribution of respondents among the groups was compared. Results: In general, the prevalence of engagement in exercise and sports did not change over a four-year period (48.8%, p = 0.256). The prevalence of regular exercise and sports increased, while engagement in irregular exercise and sports decreased (p = 0.014). Binary logistic regression analysis showed that younger age, male sex, being single, having no children under 18 years of age, selecting foods for health strengthening, positive self-assessment of nutrition and health status, use of dietary supplements, attention to purchasing healthy products, and university education attainment were associated with engagement in exercise and sports (regular or irregular) (p < 0.05). Analysis focused specifically on regular exercise and sports revealed associations with a longer time since the onset of the COVID-19 pandemic, younger age, urban residence, selection of foods for health strengthening, positive assessment of nutrition and health status, and university education attainment (p < 0.05), while no significant associations were observed with sex, marital status, presence of children under 18 years of age, use of dietary supplements, or attention to purchasing healthy products (p > 0.05). Conclusions: The overall prevalence of physical activity engagement among working-aged Lithuanian citizens did not change from 2021 to 2024, engagement in regular and irregular exercise and sports has changed. Engagement in regular and irregular exercise and sports is associated with different social profiles.