In summer, the urban heat island effect causes unbearable warmth in Shantou City, especially in the urban areas along the Inner Bay with densely populated neighborhoods. An investigation of the layout patterns of 100 residential neighborhoods along Shantou’s Inner Bay was conducted, leading to the establishment of four types and nine sub-types of idealized residential neighborhood models. Their wind speed, relative humidity, and air temperature were simulated in the ENVI-met software (version No.5.0.1). The simulation results show that high-rise buildings in the front areas play a decisive role in the overall microclimate environment. Accordingly, three principal drawbacks regarding neighborhood layout for thermal climate adaptation were extracted. Furthermore, by comparing the simulation results before and after modifying the layout of high-rise buildings, three spatial strategies to strengthen the humidification and cooling effect of sea–land breezes to optimize the outdoor microclimatic environment of neighborhoods were proposed, and these strategies were subsequently verified in the Golden-Harbor neighborhood.