Whether computed tomographic (CT) radiation really induces cancers remains controversial.
1-3 At least in children and adolescents, the association between CT radiation and carcinogenesis seems plausible given the supporting results of multiple large epidemiological studies.
4-8 However, inclusion criteria of these studies were vague, lacking information regarding the reasons for the CT scan. The reported carcinogenic risks may have been overestimated because previous studies
4-8 had potential biases, including confounding by indication (CT examination was performed because of a predisposing factor) and reverse causation (preexisting but undetectable malignant neoplasms as the reasons for the CT scan).
1,2,9 Indeed, other studies showed that such biases might lead to overestimation of the carcinogenic risk.
10-12