Dr. Girolamo Di Maio’s research primarily focuses on obesity and its systemic effects on metabolism, cellular function, and cognition. His studies explore how obesity alters gene expression, metabolic pathways, and hormonal signaling in both physiological and pathological conditions, using human and murine models. He investigates the metabolic behavior of mesenchymal stromal cells and their differentiation into adipocytes, particularly the mechanisms underlying browning—a process essential for enhancing energy expenditure and restoring metabolic balance. A key aspect of his work examines how obesity and related metabolic dysfunctions impair executive functions and brain performance. By analyzing the cross-talk between adipose tissue, inflammation, and the central nervous system, Dr. Di Maio contributes to a deeper understanding of the cognitive and behavioral consequences of metabolic disorders. His research aims to identify cellular and molecular targets to improve metabolic health and preserve cognitive integrity in obese individuals.