Nataliya Sipyagina

Dr. Nataliya Sipyagina

Institute of Physiologically Active Compounds, Chernogolovka, Moskovskaya Oblast’, Russia

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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25 October 2019 in Molecules
Verified
Journal Article
Open access
PDF file
AMAlena N. Malkova
Alena N. Malkova
NSNataliya Sipyagina
Nataliya Sipyagina
IGInna Gozhikova
Inna Gozhikova
YDYuri A. Dobrovolsky
Yuri A. Dobrovolsky
Dmitriy V. KonevDmitriy V. Konev
Dmitriy V. Konev
SLS.A. Lermontov
S.A. Lermontov
A series of carbon aerogels (C-AGs) were prepared by the pyrolysis of resorcinol-formaldehyde aerogels at 700–1100 °C as potential supercapacitor electrodes, and their texture and electrochemical properties were determined. The specific surface area of all C-AGs was in the range of 700–760 m2/g, their electron conductivity increased linearly from 0.4 to 4.46 S/cm with an increase of the pyrolysis temperature. The specific capacitance of electrode material based on C-AGs reached 100 F/g in sulfuric acid and could be realized at a 2 A/g charge-discharge current, which makes it possible to use carbon aerogels as electrode materials.

24 March 2022 in Molecules
Verified
Journal Article
Open access
PDF file
Aleksey A. UstyugovAleksey A. Ustyugov
Aleksey A. Ustyugov
NSNataliya Sipyagina
Nataliya Sipyagina
AMAlena N. Malkova
Alena N. Malkova
ESElena Straumal
Elena Straumal
LYLyudmila L. Yurkova
Lyudmila L. Yurkova
SLS.A. Lermontov
S.A. Lermontov
Cell culturing methods in its classical 2D approach have limitations associated with altered cell morphology, gene expression patterns, migration, cell cycle and proliferation. Moreover, high throughput drug screening is mainly performed on 2D cell cultures which are physiologically far from proper cell functions resulting in inadequate hit-compounds which subsequently fail. A shift to 3D culturing protocols could solve issues with altered cell biochemistry and signaling which would lead to a proper recapitulation of physiological conditions in test systems. Here, we examined porous ultra-high molecular weight polyethylene (UHMWPE) as an inexpensive and robust material with varying pore sizes for cell culturing. We tested and developed culturing protocols for immortalized human neuroblastoma and primary mice hippocampal cells which resulted in high rate of cell penetration within one week of cultivation. UHMWPE was additionally functionalized with gelatin, poly-L-lysine, BSA and chitosan, resulting in increased cell penetrations of the material. We have also successfully traced GFP-tagged cells which were grown on a UHMWPE sample after one week from implantation into mice brain. Our findings highlight the importance of UHMWPE use as a 3D matrix and show new possibilities arising from the use of cheap and chemically homogeneous material for studying various types of cell-surface interactions further improving cell adhesion, viability and biocompatibility.