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Coronavirus disease has heterogeneous clinical features; however, the reasons for the heterogeneity are poorly understood. This study aimed to identify clinical phenotypes according to patients’ temperature trajectory. A retrospective review was conducted in five tertiary hospitals in Hubei Province from November 2019 to March 2020. We explored potential temperature-based trajectory phenotypes and assessed patients’ clinical outcomes, inflammatory response, and response to immunotherapy according to phenotypes. A total of 1580 patients were included. Four temperature-based trajectory phenotypes were identified: normothermic (Phenotype 1); fever, rapid defervescence (Phenotype 2); gradual fever onset (Phenotype 3); and fever, slow defervescence (Phenotype 4). Compared with Phenotypes 1 and 2, Phenotypes 3 and 4 had a significantly higher C-reactive protein level and neutrophil count and a significantly lower lymphocyte count. After adjusting for confounders, Phenotypes 3 and 4 had higher in-hospital mortality (adjusted odds ratio and 95% confidence interval 2.1, 1.1–4.0; and 3.3, 1.4–8.2, respectively), while Phenotype 2 had similar mortality, compared with Phenotype 1. Corticosteroid use was associated with significantly higher in-hospital mortality in Phenotypes 1 and 2, but not in Phenotypes 3 or 4 (p for interaction < 0.01). A similar trend was observed for gamma-globulin. Patients with different temperature-trajectory phenotypes had different inflammatory responses, clinical outcomes, and responses to corticosteroid therapy. The online version contains supplementary material available at 10.1186/s13613-021-00907-4.
Yanfei Shen; Dechang Chen; Xinmei Huang; Guolong Cai; Qianghong Xu; Caibao Hu; Jing Yan; Jiao Liu. Novel phenotypes of coronavirus disease: a temperature-based trajectory model. Annals of Intensive Care 2021, 11, 1 .
AMA StyleYanfei Shen, Dechang Chen, Xinmei Huang, Guolong Cai, Qianghong Xu, Caibao Hu, Jing Yan, Jiao Liu. Novel phenotypes of coronavirus disease: a temperature-based trajectory model. Annals of Intensive Care. 2021; 11 ():1.
Chicago/Turabian StyleYanfei Shen; Dechang Chen; Xinmei Huang; Guolong Cai; Qianghong Xu; Caibao Hu; Jing Yan; Jiao Liu. 2021. "Novel phenotypes of coronavirus disease: a temperature-based trajectory model." Annals of Intensive Care 11, no. : 1.
Human cytomegalovirus (HCMV) remains a major public health burden worldwide. The anti-HCMV activity of glucuronomannan oligosaccharides (Gs) and sulphated glucuronomannan oligosaccharides (SGs) was investigated. Among these Gs and SGs, G4S1 and G6S1 (higher sulphated glucuronomannan tetramer and hexamer) showed satisfactory anti-HCMV activity starting at 50 μg/mL and 10 μg/mL, respectively. The results of the morphology, western blotting, qPCR and TCID50 assay showed that they prevented lytic cytopathic changes, inhibited the expression IE1/2 and UL44, and reduced the UL123 copy number and virus titre significantly. It was interesting to note that degree of sulphation and polymerization was more important for anti-HCMV activity. Moreover, the anti-HCMV activities of G4S1 and G6S1 were stable when stored at 4°C, -20°C, and -80°C for at least three months and mainly occurred in the early stage of HCMV infection through the negative charge of the sulphate groups and the interaction between SGs and the host cells.
Sanying Wang; Xiaogang Xu; Chuan Sun; Jing Zhang; Xinyue He; Zhongshan Zhang; Hong Huang; Jing Yan; Weihua Jin; Genxiang Mao. Sulphated glucuronomannan tetramer and hexamer from Sargassum thunbergii exhibit anti-human cytomegalovirus activity by blocking viral entry. Carbohydrate Polymers 2021, 273, 118510 .
AMA StyleSanying Wang, Xiaogang Xu, Chuan Sun, Jing Zhang, Xinyue He, Zhongshan Zhang, Hong Huang, Jing Yan, Weihua Jin, Genxiang Mao. Sulphated glucuronomannan tetramer and hexamer from Sargassum thunbergii exhibit anti-human cytomegalovirus activity by blocking viral entry. Carbohydrate Polymers. 2021; 273 ():118510.
Chicago/Turabian StyleSanying Wang; Xiaogang Xu; Chuan Sun; Jing Zhang; Xinyue He; Zhongshan Zhang; Hong Huang; Jing Yan; Weihua Jin; Genxiang Mao. 2021. "Sulphated glucuronomannan tetramer and hexamer from Sargassum thunbergii exhibit anti-human cytomegalovirus activity by blocking viral entry." Carbohydrate Polymers 273, no. : 118510.
The human leukocyte antigen (HLA) gene family plays a key role in the immune response and thus is crucial in many biomedical and clinical settings. Utilizing Sanger sequencing, the golden standard technology for HLA typing enables accurate identification of HLA alleles in high-resolution. However, only the commercial software, such as uTYPE, SBT-Assign, and SBTEngine, and very few open-source tools could be applied to perform HLA typing based on Sanger sequencing. We developed a user-friendly, cross-platform and open-source desktop application, known as SOAPTyping, for Sanger-based typing in HLA class I and II alleles. SOAPTyping can produce accurate results with a comprehensible protocol and featured functions. Moreover, SOAPTyping supports a more advanced group-specific sequencing primers (GSSP) module to solve the ambiguous typing results. We used SOAPTyping to analyze 36 samples with known HLA typing from the University of California Los Angeles (UCLA) International HLA DNA Exchange platform and 100 anonymous clinical samples, and the HLA typing results from SOAPTyping are identical to the golden results and 5.5 times faster than commercial software uTYPE, which shows the usability of SOAPTyping. We introduce the SOAPTyping as the first open-source and cross-platform HLA typing software with the capability of producing high-resolution HLA typing predictions from Sanger sequence data.
Yong Zhang; Yongsheng Chen; Huixin Xu; Junbin Fang; Zijian Zhao; Weipeng Hu; Xiaoqin Yang; Jia Ye; Yun Cheng; Jiayin Wang; Weiqiang Sun; Huanming Yang; Jing Yan; Lin Fang. SOAPTyping: an open-source and cross-platform tool for sequence-based typing for HLA class I and II alleles. BMC Bioinformatics 2020, 21, 1 -9.
AMA StyleYong Zhang, Yongsheng Chen, Huixin Xu, Junbin Fang, Zijian Zhao, Weipeng Hu, Xiaoqin Yang, Jia Ye, Yun Cheng, Jiayin Wang, Weiqiang Sun, Huanming Yang, Jing Yan, Lin Fang. SOAPTyping: an open-source and cross-platform tool for sequence-based typing for HLA class I and II alleles. BMC Bioinformatics. 2020; 21 (1):1-9.
Chicago/Turabian StyleYong Zhang; Yongsheng Chen; Huixin Xu; Junbin Fang; Zijian Zhao; Weipeng Hu; Xiaoqin Yang; Jia Ye; Yun Cheng; Jiayin Wang; Weiqiang Sun; Huanming Yang; Jing Yan; Lin Fang. 2020. "SOAPTyping: an open-source and cross-platform tool for sequence-based typing for HLA class I and II alleles." BMC Bioinformatics 21, no. 1: 1-9.
Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with anti-hCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenuated by pre-incubation with piceatannol in a dose-dependent manner. These results demonstrated that piceatannol suppressed the hCMV infection via inhibition of the activation of p16INK4a and cellular senescence induced by hCMV. Together, these findings indicate piceatannol as a novel and potent anti-hCMV agent with the potential to be developed as an effective treatment for chronic hCMV infection.
San-Ying Wang; Jing Zhang; Xiao-Gang Xu; Hui-Li Su; Wen-Min Xing; Zhong-Shan Zhang; Wei-Hua Jin; Ji-Huan Dai; Ya-Zhen Wang; Xin-Yue He; Chuan Sun; Jing Yan; Gen-Xiang Mao. Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro. Journal of Microbiology 2020, 58, 716 -723.
AMA StyleSan-Ying Wang, Jing Zhang, Xiao-Gang Xu, Hui-Li Su, Wen-Min Xing, Zhong-Shan Zhang, Wei-Hua Jin, Ji-Huan Dai, Ya-Zhen Wang, Xin-Yue He, Chuan Sun, Jing Yan, Gen-Xiang Mao. Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro. Journal of Microbiology. 2020; 58 (8):716-723.
Chicago/Turabian StyleSan-Ying Wang; Jing Zhang; Xiao-Gang Xu; Hui-Li Su; Wen-Min Xing; Zhong-Shan Zhang; Wei-Hua Jin; Ji-Huan Dai; Ya-Zhen Wang; Xin-Yue He; Chuan Sun; Jing Yan; Gen-Xiang Mao. 2020. "Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro." Journal of Microbiology 58, no. 8: 716-723.
Calorie restriction (CR) is a nongenetic intervention with a robust effect on delaying aging in mammals and other organisms. A mild stimulation on mitochondrial biogenesis induced by CR seems to be an important action mode for its benefits. Here, we reported that a component isolated from Rhodiola rosea L., salidroside, delays replicative senescence in human fibroblasts, which is related to its stimulation on mitochondrial biogenesis by activating SIRT1 partly resulted from inhibition on miR-22. Salidroside increased the mitochondrial mass that accompanied an increment of the key regulators of mitochondrial biogenesis including PGC-1α, NRF-1, and TFAM and reversed the mitochondrial dysfunction in presenescent 50PD cells, showing a comparable effect to that of resveratrol. SIRT1 is involved in the inducement of mitochondrial biogenesis by salidroside. The declined expression of SIRT1 in 50PD cells compared with the young 30PD cells was prevented upon salidroside treatment. In addition, pretreatment of EX-527, a selective SIRT1 inhibitor, could block the increased mitochondrial mass and decreased ROS production induced by salidroside in 50PD cells, resulting in an accelerated cellular senescence. We further found that salidroside reversed the elevated miR-22 expression in presenescent cells according to a miRNA array analysis and a subsequent qPCR validation. Enforced miR-22 expression by using a Pre-miR-22 lentiviral construct induced the young fibroblasts (30PD) into a senescence state, accompanied with increased senescence-related molecules including p53, p21, p16, and decreased SIRT1 expression, a known target of miR-22. However, salidroside could partly impede the senescence progression induced by lenti-Pre-miR-22. Taken together, our data suggest that salidroside delays replicative senescence by stimulating mitochondrial biogenesis partly through a miR22/SIRT1 pathway, which enriches our current knowledge of a salidroside-mediated postpone senility effect and provides a new perspective on the antidecrepitude function of this naturally occurring compound in animals and humans.
Gen-Xiang Mao; Xiao-Gang Xu; San-Ying Wang; Hui-Fen Li; Jing Zhang; Zhong-Shan Zhang; Hui-Li Su; Sha-Sha Chen; Wen-Min Xing; Ya-Zhen Wang; Ji-Huan Dai; Guo-Fu Wang; Sean X. Leng; Jing Yan. Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway. Oxidative Medicine and Cellular Longevity 2019, 2019, 1 -13.
AMA StyleGen-Xiang Mao, Xiao-Gang Xu, San-Ying Wang, Hui-Fen Li, Jing Zhang, Zhong-Shan Zhang, Hui-Li Su, Sha-Sha Chen, Wen-Min Xing, Ya-Zhen Wang, Ji-Huan Dai, Guo-Fu Wang, Sean X. Leng, Jing Yan. Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway. Oxidative Medicine and Cellular Longevity. 2019; 2019 ():1-13.
Chicago/Turabian StyleGen-Xiang Mao; Xiao-Gang Xu; San-Ying Wang; Hui-Fen Li; Jing Zhang; Zhong-Shan Zhang; Hui-Li Su; Sha-Sha Chen; Wen-Min Xing; Ya-Zhen Wang; Ji-Huan Dai; Guo-Fu Wang; Sean X. Leng; Jing Yan. 2019. "Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway." Oxidative Medicine and Cellular Longevity 2019, no. : 1-13.
SummaryThe human leukocyte antigen (HLA) gene family plays a key role in the immune response and thus is crucial in many biomedical and clinical settings. Utilizing Sanger sequencing - the gold standard technology for HLA typing – enables accurate identification of HLA alleles with high-resolution. However, there exists a current hurdle that only commercial software such as UType, SBT-Assign and SBTEngine, instead of any open source tools could be applied to perform HLA typing based on Sanger sequencing. To fill the gap, we developed a stand-alone, open-source and cross-platform software, known as SOAPTyping, for Sanger-based typing in HLA class I and II alleles.Availability and implementationSOAPTyping is implemented in C++ language and Qt framework, which is supported on Windows, Mac and Linux. Source code and detailed documentation are accessible via the project GitHub page: https://github.com/BGI-flexlab/[email protected] informationSupplementary data are available at Bioinformatics online.
Yong Zhang; Yongsheng Chen; Huixin Xu; Junbin Fang; Zijian Zhao; Weipeng Hu; Xiaoqin Yang; Jia Ye; Yun Cheng; Jiayin Wang; Huangming Yang; Jing Yan; Lin Fang. SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles. 2019, 674648 .
AMA StyleYong Zhang, Yongsheng Chen, Huixin Xu, Junbin Fang, Zijian Zhao, Weipeng Hu, Xiaoqin Yang, Jia Ye, Yun Cheng, Jiayin Wang, Huangming Yang, Jing Yan, Lin Fang. SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles. . 2019; ():674648.
Chicago/Turabian StyleYong Zhang; Yongsheng Chen; Huixin Xu; Junbin Fang; Zijian Zhao; Weipeng Hu; Xiaoqin Yang; Jia Ye; Yun Cheng; Jiayin Wang; Huangming Yang; Jing Yan; Lin Fang. 2019. "SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles." , no. : 674648.
Comprehensive geriatric assessment is the major approach in screening geriatric syndrome. The aim of this expert consensus is to supply standard operating procedures for clinical practice of comprehensive geriatric assessment in China.
Xujiao Chen; Jing Yan; Jianye Wang; Pulin Yu. Chinese expert consensus on the application of comprehensive geriatric assessment for the elderly. AGING MEDICINE 2018, 1, 100 -105.
AMA StyleXujiao Chen, Jing Yan, Jianye Wang, Pulin Yu. Chinese expert consensus on the application of comprehensive geriatric assessment for the elderly. AGING MEDICINE. 2018; 1 (2):100-105.
Chicago/Turabian StyleXujiao Chen; Jing Yan; Jianye Wang; Pulin Yu. 2018. "Chinese expert consensus on the application of comprehensive geriatric assessment for the elderly." AGING MEDICINE 1, no. 2: 100-105.
Senescence is a complex multiple factor proces, which is still poorly understood. The purpose of this study was to find the proteome of cultured human fetal lung diploid fibroblasts (2BS) of different population doubling (PD), as well as the altered proteome induced by salidroside (SAL) in 2BS cells. Proteins were identified by two-dimensional electrophoresis (2-DE) combining matrix-assisted laser desorption/ionization-time and flight mass spectrometry (MAL DI-TOF/MS). As a result, we found 16 proteins with two-fold variations in senescent cells or after SAL treatment, some being reduced such as reticulocalbin-1, heat shock protein beta-6, elongation factor 1-delta, F-actin-capping protein subunit alpha-1, and chloride intracellular channel 1. In contrast, 40S ribosomal protein SA, proteasome subunit alpha type-5, and zinc finger BED domain-containing protein 5 increased with cell age. Furthermore, heat shock protein beta-6, Zinc finger BED domain-containing protein 5 was increased in PD30 cells after 10 μM SAL treatment, whereas, elongation factor 1-delta, 6-phosphogluconolactonase, Nucleoside diphosphate kinase A, F-actin-capping protein subunit alpha-1, Probable ATP-dependent RNA helicase DDX41, Chloride intracellular channel 1, and Peroxiredoxin-6 were increased in PD50 cells after 10 μM SAL treatment. Some of these proteins were involved in the protein synthetic and degradative pathways, which emphasizes the metabolic disorder or functional impairment of cell senescence. Moreover, these proteins could be candidate biomarkers for evaluating the SAL anti-senescence effect.
Wenmin Xing; Wenyan Gao; Huili Su; Sanying Wang; Jing Zhang; Genxiang Mao; Jing Yan. Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach. Environmental Toxicology and Pharmacology 2018, 58, 114 -121.
AMA StyleWenmin Xing, Wenyan Gao, Huili Su, Sanying Wang, Jing Zhang, Genxiang Mao, Jing Yan. Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach. Environmental Toxicology and Pharmacology. 2018; 58 ():114-121.
Chicago/Turabian StyleWenmin Xing; Wenyan Gao; Huili Su; Sanying Wang; Jing Zhang; Genxiang Mao; Jing Yan. 2018. "Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach." Environmental Toxicology and Pharmacology 58, no. : 114-121.
The objective of this study was to determine the prevalence of and risk factors for dementia in residents aged 65 years and older in a Chinese nursing home. A cross-sectional study was carried out in a nursing home located in Hangzhou, Zhejiang Province, China. Cognitive status, including the presence of dementia and mild cognitive impairment (MCI), was measured using a combination of medical history and objective cognitive assessments. Logistic regression analysis was conducted to predict the associated risk factors. In total, 943 residents (334 males and 609 females) aged 84.00±6.67 years (mean±SD) were included. Dementia was diagnosed in 420 (44.5%) residents, and MCI was diagnosed in 195 (20.7%). Mild, moderate, and severe dementia were present in 20.3%, 14.0%, and 65.7% of those in the dementia group, respectively. Logistic regression analysis revealed that dementia was associated with a low education level (p=0.000), an advanced age (p=0.010), and a history of stroke (p=0.023). Our study found a high prevalence of dementia in a Chinese nursing home, and a high prevalence of patients with severe dementia. Risk factors for dementia included a low educational level, an advanced age, and a history of stroke. Appropriate interventions need to be applied to this population.
Shanhu Xu; Xiaoqing Jin; Caixia Liu; Yu Jin; Ying Xu; Linhui Chen; Saizhu Xu; Hongying Tang; Jing Yan. Investigating the Prevalence of Dementia and Its Associated Risk Factors in a Chinese Nursing Home. Journal of Clinical Neurology 2017, 13, 10 -14.
AMA StyleShanhu Xu, Xiaoqing Jin, Caixia Liu, Yu Jin, Ying Xu, Linhui Chen, Saizhu Xu, Hongying Tang, Jing Yan. Investigating the Prevalence of Dementia and Its Associated Risk Factors in a Chinese Nursing Home. Journal of Clinical Neurology. 2017; 13 (1):10-14.
Chicago/Turabian StyleShanhu Xu; Xiaoqing Jin; Caixia Liu; Yu Jin; Ying Xu; Linhui Chen; Saizhu Xu; Hongying Tang; Jing Yan. 2017. "Investigating the Prevalence of Dementia and Its Associated Risk Factors in a Chinese Nursing Home." Journal of Clinical Neurology 13, no. 1: 10-14.
The occurrence, bleeding, and treatment of internal mammary artery (IMA) injury after blunt chest trauma have not been well described in the literature. We reviewed articles published from July 1977 to February 2014 describing IMA injury after blunt chest trauma in 49 patients. There was a predominant incidence in males and on the left side. Blunt trauma to the IMA can cause anterior mediastinal hematoma, hemothorax, pseudoaneurysm, arteriovenous fistula, and extra-pleural hematoma. Of the 49 patients studied, 20 underwent embolization, 22 underwent surgical operation, 4 were managed by clinical observation, and 3 had undescribed treatment. Different parts and extents of IMA injury, adjacent vein injury, as well as the integrity of the pleura determined differences in bleeding modality. Prompt diagnosis, complete hemostasis, aggressive resuscitation, and multidisciplinary teams are recommended for patients with IMA injury.
Jin-Ming Chen; Jin Lv; Kai Ma; Jing Yan. Assessment of internal mammary artery injury after blunt chest trauma: a literature review. Journal of Zhejiang University-SCIENCE B 2014, 15, 864 -869.
AMA StyleJin-Ming Chen, Jin Lv, Kai Ma, Jing Yan. Assessment of internal mammary artery injury after blunt chest trauma: a literature review. Journal of Zhejiang University-SCIENCE B. 2014; 15 (10):864-869.
Chicago/Turabian StyleJin-Ming Chen; Jin Lv; Kai Ma; Jing Yan. 2014. "Assessment of internal mammary artery injury after blunt chest trauma: a literature review." Journal of Zhejiang University-SCIENCE B 15, no. 10: 864-869.
The prevalence of hypertension in China has risen dramatically in recent decades, but it is not well understood if hypertension is adequately controlled in the elderly population in Southern China. A provincial survey was performed in order to estimate the prevalence of hypertension control and the associated factors in the elderly population. A cross-sectional survey was conducted in 6 community health service centers across 12 counties in Southern China from October 2010 to April 2011. Recruitment included a total of 10644 hypertensive subjects aged 60 or older. Basic lab tests and physical examinations were administrated on each subject. In addition, each subject completed a standardized questionnaire. The 10644 participants (mean age of 70.3 years) included 5527 women (51.9%), 5117 men (48.1%), 3148 overweight subjects (29.57%), 846 (7.95%) obese subjects, 1654 smokers (15.54%) and 1750 consumers of alcohol (16.44%). The control, treatment and awareness of hypertension were 44.6%, 50.3% and 46.3%, respectively. Most treated hypertensives (68.57%) used combination therapy of antihypertensive medications, and those using long-acting antihypertensive medications had a higher rate of adequately controlled hypertension. Results showed that elderly, living in rural and suburban areas, low education level, family history of hypertension, smoking, excessive salt consumption, lack of physical activity, overweight, obese and diabetes were associated with uncontrolled hypertension. Lack of adequate hypertension control is relatively high among the elderly in Southern China. Hypertension awareness and early treatment are needed in this population, especially among suburban population, as well as adopting appropriate antihypertensive medication therapy and healthy lifestyles.
Li Yang; Xiaoling Xu; Jing Yan; Wei Yu; Xinhua Tang; Haibin Wu; Christy L Parkin. Analysis on associated factors of uncontrolled hypertension among elderly hypertensive patients in Southern China: a community-based, cross-sectional survey. BMC Public Health 2014, 14, 1 -8.
AMA StyleLi Yang, Xiaoling Xu, Jing Yan, Wei Yu, Xinhua Tang, Haibin Wu, Christy L Parkin. Analysis on associated factors of uncontrolled hypertension among elderly hypertensive patients in Southern China: a community-based, cross-sectional survey. BMC Public Health. 2014; 14 (1):1-8.
Chicago/Turabian StyleLi Yang; Xiaoling Xu; Jing Yan; Wei Yu; Xinhua Tang; Haibin Wu; Christy L Parkin. 2014. "Analysis on associated factors of uncontrolled hypertension among elderly hypertensive patients in Southern China: a community-based, cross-sectional survey." BMC Public Health 14, no. 1: 1-8.