Carbon dots (CDs) have many advantages, such as tunable photoluminescence, large two-photon absorption cross-sections, easy functionalization, low toxicity, chemical inertness, good dispersion, and biocompatibility. Halogen doping further improves the optical and physicochemical properties of CDs, extending their applications in fluorescence sensors, biomedicine, photocatalysis, anti-counterfeiting encryption, and light-emitting diodes. This review briefly describes the preparation of CDs via the “top-down” and “bottom-up” approaches and discusses the preparation methods and applications of halogen (fluorine, chlorine, bromine, and iodine)-doped CDs. The main challenges of CDs in the future are the elucidation of the luminescence mechanism, fine doping with elements (proportion, position, etc.), and their incorporation in practical devices.

Iodine-doped carbon quantum dots (I-CQDs) were synthesized via p-iodobenzoic acid self-doping for the detection of ferric ions (Fe³⁺) and cell imaging.