Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water-soluble drugs. Solid dispersions of weakly water-soluble drugs with water-soluble carriers have lowered the frequency of these problems and improved dissolution. Solid dispersion is a solubilization technology emphasizing mainly on, drug-polymer two-component systems in which drug dispersion and its stabilization is the key to formulation development. Therefore, this technology is recognized as an exceptionally useful means of improving the dissolution properties of poorly water-soluble drugs and in the latest years, a big deal of understanding has been accumulated about solid dispersion, however, their commercial application is limited. In this review article, emphasis is placed on solubility, BCS classification, and carriers. Moreover, this article presents the diverse preparation techniques for solid dispersion and gathers some of the recent technological transfers. The different types of solid dispersions based on the carrier used and molecular arrangement were underlined. Additionally, it summarizes the mechanisms, the methods of preparing solid dispersions, and the marketed drugs that are available using solid dispersion approaches.

In this study, four different olive fruit and leaf varieties collected in Jordan were assessed for quality using both chemical and biological methods. To quantify the phenol and antioxidant content in the olive fruit and leaf extracts, a validated UV method was employed. The antioxidant activity and total phenolic content of fruit and leaf extracts of the olive varieties were measured using the DPPH radical scavenging assay and Folin–Ciocalteu colorimetric method, respectively. The researchers also conducted a biological assay against colon cells to examine the potential health benefits of the olive extracts. The results showed that the phenol content of the samples varied depending on the region they were collected from and that they contained a significant amount of antioxidants. Additionally, it was observed that the samples with higher antioxidant content had lower cell viability against colon cells. Overall, this study suggests that olive extracts may have potential health benefits for colon health and that the phenol and antioxidant content of the extracts can vary depending on the source of the olives.

Pomegranate (Punica granatum) has become an increasingly popular functional food and source of nutraceuticals, owing to its high antioxidant and anti-inflammatory properties. Various parts of the p...

This study aims to delineate the pivotal role of ChatGPT, an Artificial intelligence-driven (AI) language model, in revolutionizing drug delivery research within the pharmaceutical sciences domain. The investigation adopted a structured approach involving systematic literature exploration across databases such as PubMed, ScienceDirect, IEEE Xplore, and Google Scholar. A selection criterion emphasizing peer-reviewed articles, conference proceedings, patents, and seminal texts highlights the integration of AI-driven chatbots, specifically ChatGPT, into various facets of drug delivery research and development. ChatGPT exhibits multifaceted contributions to drug delivery innovation, streamlining drug formulation optimization, predictive modeling, regulatory compliance, and fostering patient-centric approaches. Real-world case studies have underscored its efficacy in expediting drug development timelines and enhancing research efficiency. This paper delves into the diverse applications of ChatGPT, showcasing its potential across drug delivery systems. It elucidates its capabilities in accelerating research phases, facilitating formulation development, predictive modeling for efficacy and safety, and simplifying regulatory compliance. This discussion outlines the transformative impact of ChatGPT in reshaping drug delivery methodologies. In conclusion, ChatGPT, an AI-driven chatbot, has emerged as a transformative tool in pharmaceutical research. Their integration expedites drug development pipelines, ensures effective drug delivery solutions, and augments healthcare advancements. Embracing AI tools such as ChatGPT has become pivotal in evolving drug delivery methodologies for global patient welfare.

Inappropriate antibiotic usage is a critical issue in many countries, especially in low- and middle-income countries, where access to antibiotics may be easier but proper prescribing and use practices are often lacking. This can contribute to the development of antibiotic resistance, which poses a significant threat to global public health. The research on assessing the awareness, attitude, and knowledge of senior pharmacy students in Jordanian universities regarding antibiotic use and resistance can have several impacts. Firstly, it can shed light on the current level of knowledge and awareness among pharmacy students, who are future healthcare professionals, and identify any gaps or misconceptions that need to be addressed through education and training programs. Secondly, the research findings can be used to develop targeted interventions to improve appropriate antibiotic use and reduce the emergence and spread of antibiotic resistance in Jordan and potentially other countries with similar contexts. Finally, the study can contribute to the growing body of knowledge on antibiotic resistance and help inform global efforts to address this critical public health issue. This study aimed to assess the awareness, attitude, and knowledge of senior pharmacy students in Jordanian universities in relation to antibiotic use and antibiotic resistance (AR). A proportionate random sampling method was employed, and a questionnaire was administered to 400 final-year pharmacy students from three universities in the northern region of Jordan over a period of six months (6/3/2022- 11/3/2022). The data was distributed electronically using emails, and Excel was used for data analysis. The findings revealed that the pharmacy students displayed a high level of knowledge (mean score of 86.5%), positive attitude (mean score of 87.2%), and responsible behavior towards antibiotic use, indicative of their awareness and understanding of the risks of AR. The statistical methods used to analyze the data included descriptive statistics and inferential statistics such as t-tests and ANOVA. The study also identified some areas of potential improvement, such as enhancing knowledge about antibiotic resistance mechanisms and the importance of completing the full course of antibiotics. To address these gaps, targeted educational interventions can be developed to empower pharmacy students to promote appropriate antibiotic use and minimize the emergence of antibiotic resistance.

Objective: This study aimed to formulate and evaluate solid dispersions of acyclovir using Polyethylene Glycol (PEG) polymers (PEG 3350, PEG 4000, and PEG 6000) in varying ratios to improve their oral bioavailability. Methods: Solid dispersions of acyclovir with PEG 3350, PEG 4000, and PEG 6000 were prepared at different weight ratios (1:5, 1:20, and 5:1) using the solvent evaporation method. Physical mixtures were also prepared for comparison purposes. Characterization involved Differential Scanning Calorimetry (DSC) to study thermal behavior, X-ray powder Diffraction (XRPD) to assess the crystalline state, Fourier Transform Infrared Spectroscopy (FTIR) for molecular interactions, and dissolution studies using USP apparatus type 2 to evaluate drug release profiles. Results: Among the tested formulations, the solid dispersion of acyclovir with PEG 4000 at a 20:1 ratio demonstrated the most favourable dissolution profile, with over 50% drug release within the first 10 min. DSC analysis indicated a significant reduction in the crystallinity of acyclovir within the solid dispersions, particularly with PEG 4000. XRPD confirmed the transformation of acyclovir to an amorphous state, while FTIR spectroscopy revealed molecular interactions between acyclovir and PEG, indicative of enhanced solubility. Dissolution studies further corroborated the superior performance of the 20:1 PEG 4000 formulation, which showed a remarkable increase in solubility compared to other ratios and physical mixtures. Mathematical modeling using the Weibull and Logistic models suggested controlled and predictable release kinetics for the optimized formulation. Conclusion: Overall, this study underscores the potential of solid dispersion formulations, particularly the 20:1 ratio of PEG 4000 to acyclovir, in enhancing the oral bioavailability of poorly water-soluble drugs, such as acyclovir, offering valuable insights for pharmaceutical formulations and drug delivery systems.