The effect of global climate change on infectious disease remains hotly debated because multiple extrinsic and intrinsic drivers interact to influence transmission dynamics in nonlinear ways. The dominant drivers of widespread pathogens, like West Nile virus, can be challenging to identify due to regional variability in vector and host ecology, with past studies producing disparate findings. Here, we used analyses at national and state scales to examine a suite of climatic and intrinsic drivers of continental-scale West Nile virus epidemics, including an empirically derived mechanistic relationship between temperature and transmission potential that accounts for spatial variability in vectors. We found that drought was the primary climatic driver of increased West Nile virus epidemics, rather than within-season or winter temperatures, or precipitation independently. Local-scale data from one region suggested drought increased epidemics via changes in mosquito infection prevalence rather than mosquito abundance. In addition, human acquired immunity following regional epidemics limited subsequent transmission in many states. We show that over the next 30 years, increased drought severity from climate change could triple West Nile virus cases, but only in regions with low human immunity. These results illustrate how changes in drought severity can alter the transmission dynamics of vector-borne diseases.

We present an intercomparison of a suite of high‐resolution downscaled climate projections based on a six‐member General Circulation Model (GCM) ensemble from Coupled Models Intercomparison Project (CMIP6). The CMIP6 GCMs have been downscaled using dynamical and statistical downscaling techniques based on two meteorological reference observations over the conterminous United States. We use the regional climate model, RegCM4, for dynamical downscaling, double bias correction constructed analogs method for statistical downscaling, and Daymet and Livneh datasets as the reference observations for statistical training and bias‐correction. We evaluate the performances of downscaled data in both historical and future periods under the SSP585 scenario. While dynamical downscaling improves the simulation of some performance evaluation indices, it adds an extra bias in others, highlighting the need for statistical correction before its use in impact assessments. Downscaled datasets after bias‐correction compare exceptionally well with observations. However, the choice of downscaling techniques and the underlying reference observations influence the hydroclimate characteristics of downscaled data. For instance, the statistical downscaling generally preserves the GCMs climate change signal but overestimates the frequency of hot extremes. Similarly, simulated future changes are sensitive to the choice of reference observations, particularly for precipitation extremes that exhibit a higher projected increase in the ensembles trained and/or corrected by Daymet than Livneh. Overall, these results demonstrate that multiple factors, including downscaling techniques and reference observations, can substantially influence the outcome of downscaled climate projections and stress the need for a comprehensive understanding of such method‐based uncertainties.

Probable maximum precipitation (PMP), defined as the largest rainfall depth that could physically occur under a series of adverse atmospheric conditions, has been an important design criterion for critical infrastructures such as dams and nuclear power plants. To understand how PMP may respond to projected future climate forcings, we used a physics‐based numerical weather simulation model to estimate PMP across various durations and areas over the Alabama‐Coosa‐Tallapoosa (ACT) River Basin in the southeastern United States. Six sets of Weather Research and Forecasting (WRF) model experiments driven by both reanalysis and global climate model projections, with a total of 120 storms, were conducted. The depth‐area‐duration relationship was derived for each set of WRF simulations and compared with the conventional PMP estimates. Our results showed that PMP driven by projected future climate forcings is higher than 1981–2010 baseline values by around 20% in the 2021–2050 near‐future and 44% in the 2071–2100 far‐future periods. The additional sensitivity simulations of background air temperature warming also showed an enhancement of PMP, suggesting that atmospheric warming could be one important factor controlling the increase in PMP. In light of the projected increase in precipitation extremes under a warming environment, the reasonableness and role of PMP deserve more in‐depth examination.