This review focuses on the use of superficially porous particles (SPPs) as chiral stationary phases for ultra-high performance liquid enantioseparations.

5-(Pyrrolidin-2-yl)tetrazole functionalized silica prepared by photoinduced thiol–ene coupling is packed into a short stainless steel column. The resulting packed-bed microreactor is conveniently heated to perform environmentally benign continuous-flow aldol reactions with good stereoselectivities, complete conversion efficiencies, and long term stability of the packing material.