To identify the socio-demographic profiles, suicidal ideation, the presence of mental disorders and the quality of life of patients using mental health services in Arapiraca, Alagoas, Brazil. Interviews were conducted in family health units and the Psychosocial Attention Center. The sample included 202 mental disorder patients with a risk of suicide attempts, 207 mental disorder patients without a risk of suicide attempts and 196 controls. This study used an identification questionnaire, the abbreviated World Health Organization Quality of Life questionnaire, Beck's Suicidal Ideation Scale and the Mini International Neuropsychiatric Interview. Patients who had a mental disorder and a risk of suicide attempts tended to be single, had less education and lower family income, were not working and showed lower scores in quality of life domains; 73 of these patients had suicidal ideation in the previous week. Depressive disorders, manic episodes, hypomanic episodes, social phobias, obsessive compulsive disorder, post-traumatic stress disorder, psychotic syndromes and generalized anxiety disorder were more frequent and statistically significant for patients at risk for suicide attempts. The management of patients with a risk of suicide attempts must focus on individual patients because this risk is directly linked to changes in quality of life and the improvement of these patients' prognosis.

RESUMO Objetivo Evidenciar os fatores predisponentes relativos à ansiedade em minorias sexuais e de gênero na literatura. Métodos Trata-se de uma revisão integrativa. A busca dos artigos foi realizada em três bases de dados eletrônicas: PubMed/Medline, Scopus e ISI Web of Knowledge . Foram utilizados os descritores “ anxiety ”, “ LGBT people ”, “ gay ”, “ bisexual ”, “ lesbian ” e “ transgender ”, com textos completos, publicados no período de 2013 a 2018, no idioma inglês, e foi usado o operador boleano AND . Resultados Foram encontrados 712 artigos. Cinquenta e oito (58) artigos foram selecionados para serem lidos na íntegra e 13 atenderam aos critérios de inclusão desta revisão. As evidências mostram que a população LGBT apresenta maior risco para transtornos mentais, entre eles a ansiedade, quando comparada aos heterossexuais. O aparecimento dos sinais e sintomas de ansiedade estão relacionados com a vergonha e o comportamento evitativo dessa população devido à forte discriminação e à ausência de apoio social e familiar, o que ocasiona altos níveis de angústia. Apenas dois artigos estudaram menores de 18 anos. Conclusões Os profissionais da saúde devem estar abertos, acolhedores e atentos à saúde mental desse público, visando contribuir com a promoção da saúde, apoio social, familiar e a redução da discriminação.

Objective: This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. Methods: a systematic review with meta-analysis was conducted of the associations between the TNF-α (−308G/A) and IL-10 (−819C/T) polymorphisms and dengue. Results: A total of eight case-controls studies involving 384 individuals with symptomatic dengue, 571 individuals with dengue hemorrhagic fever, and 995 healthy controls were considered in the meta-analysis. There was no significant association between TNF-α (−308G/A) and IL-10 (−819C/T) polymorphism and dengue in overall population. However, stratifying meta-analysis by groups, the meta-analysis revealed association between the TNF-α −308 G/G (OR: 1.62, CI: 1.02–2.57, p = 0.04) genotype and allele G (OR: 1.62, CI: 1.04–2.55, p = 0.03) that confers susceptibility to symptomatic dengue, while the TNF-α −308 G/A genotype (OR: 0.69, CI = 0.39–0.99, p = 0.04) and allele A (OR: 0.64, CI: 0.41–1.00, p = 0.05) confers protection to symptomatic dengue. No difference was observed for the TNF-α (−308) and IL-10 (−819C/T) polymorphisms in the comparisons of hemorrhagic dengue versus control and hemorrhagic dengue versus symptomatic dengue. Conclusion: This meta-analysis showed that TNF-α (−308) polymorphism is associated with dengue symptomatic susceptibility.

Large-scale genotyping and next-generation sequencing techniques have allowed great advances in the field of molecular genetics. Numerous common variants of low...

Key words: Suicide attempt; poisoning; emergency