Early detection of breast cancer is an essential procedure to reduce the mortality rate among women. In this paper, a new AI-based computer-aided diagnosis (CAD) framework called ETECADx is proposed by fusing the benefits of both ensemble transfer learning of the convolutional neural networks as well as the self-attention mechanism of vision transformer encoder (ViT). The accurate and precious high-level deep features are generated via the backbone ensemble network, while the transformer encoder is used to diagnose the breast cancer probabilities in two approaches: Approach A (i.e., binary classification) and Approach B (i.e., multi-classification). To build the proposed CAD system, the benchmark public multi-class INbreast dataset is used. Meanwhile, private real breast cancer images are collected and annotated by expert radiologists to validate the prediction performance of the proposed ETECADx framework. The promising evaluation results are achieved using the INbreast mammograms with overall accuracies of 98.58% and 97.87% for the binary and multi-class approaches, respectively. Compared with the individual backbone networks, the proposed ensemble learning model improves the breast cancer prediction performance by 6.6% for binary and 4.6% for multi-class approaches. The proposed hybrid ETECADx shows further prediction improvement when the ViT-based ensemble backbone network is used by 8.1% and 6.2% for binary and multi-class diagnosis, respectively. For validation purposes using the real breast images, the proposed CAD system provides encouraging prediction accuracies of 97.16% for binary and 89.40% for multi-class approaches. The ETECADx has a capability to predict the breast lesions for a single mammogram in an average of 0.048 s. Such promising performance could be useful and helpful to assist the practical CAD framework applications providing a second supporting opinion of distinguishing various breast cancer malignancies.

Breast cancer, which attacks the glandular epithelium of the breast, is the second most common kind of cancer in women after lung cancer, and it affects a significant number of people worldwide. Based on the advantages of Residual Convolutional Network and the Transformer Encoder with Multiple Layer Perceptron (MLP), this study proposes a novel hybrid deep learning Computer-Aided Diagnosis (CAD) system for breast lesions. While the backbone residual deep learning network is employed to create the deep features, the transformer is utilized to classify breast cancer according to the self-attention mechanism. The proposed CAD system has the capability to recognize breast cancer in two scenarios: Scenario A (Binary classification) and Scenario B (Multi-classification). Data collection and preprocessing, patch image creation and splitting, and artificial intelligence-based breast lesion identification are all components of the execution framework that are applied consistently across both cases. The effectiveness of the proposed AI model is compared against three separate deep learning models: a custom CNN, the VGG16, and the ResNet50. Two datasets, CBIS-DDSM and DDSM, are utilized to construct and test the proposed CAD system. Five-fold cross validation of the test data is used to evaluate the accuracy of the performance results. The suggested hybrid CAD system achieves encouraging evaluation results, with overall accuracies of 100% and 95.80% for binary and multiclass prediction challenges, respectively. The experimental results reveal that the proposed hybrid AI model could identify benign and malignant breast tissues significantly, which is important for radiologists to recommend further investigation of abnormal mammograms and provide the optimal treatment plan.

Breast cancer remains a leading cause of mortality in women, underscoring the need for timely and accurate diagnosis. This paper addresses this challenge by introducing a comprehensive explainable federated learning framework for breast cancer prediction. We evaluate three deep learning approaches in both centralized and federated scenario settings: (1) individual artificial intelligence (AI) models, (2) high-level feature space ensemble models, and (3) a hybrid model combining global Vision Transformer (ViT) and local convolutional neural network (CNN) features. These models are assessed on binary, multi-class, and Breast Imaging Reporting and Data System (BI-RADS) classification tasks using a unique dataset encompassing real-world risk factors. In the federated scenario, we employ three clients with the same approaches as the centralized setting, aggregating their predictions using an AI global model. Explainable AI (XAI) technique is incorporated to enhance AI models’ transparency. Our federated learning approach demonstrates superior performance, achieving accuracies of 98.65%, 97.30%, and 95.59% for binary, multi-class, and BI-RADS tasks, respectively. The proposed model, evaluated with a 95% Confidence Interval (CI) and Areas Under Curve (AUC) curves, registers top classifiers with an AUC of 0.970 [0.917–1]. Local Interpretable Model-Agnostic Explanations (LIME) XAI-based federated learning framework offers a promising solution for privacy-preserving and accurate breast cancer prediction in both research and clinical practice.

Valvular heart disease (VHD) is one of the primary causes of cardiovascular illnesses with high mortality rates worldwide. Early detection of VHD enables optimal treatment and stops the onset of heart problems. Even with the capability of diagnosing VHD, many misdiagnosed cases have existed. Therefore, in this work, four AI models are proposed to effectively diagnose heart sounds generated from phonocardiography (PCG) recordings, namely VGG16, ResNet50, Transformer Encoder, and a hybrid framework based on ResNet50 and the Transformer Encoder with Multiple Layer Perceptron (MLP). Two benchmark datasets are involved, namely Yaseen and PhysioNet 2016 challenge datasets. The suggested AI models can classify heart sounds in two scenarios: Multi-class scenario (aortic stenosis, mitral stenosis, mitral regurgitation, mitral valve prolapse, and normal) and binary classification (normal and abnormal). Melfrequency cepstral coefficients (MFCCs) features are extracted from heart sound files, where a 22050-sample rate is used with 12 seconds as the maximum clip duration for each audio file. Additionally, a pre-processing technique is applied using the z-score normalization and Discrete cosine transform (DCT) algorithms. Besides, noise, stretching, and shifting are used to augment sound data. By using a 5-fold cross-validation technique, the proposed hybrid framework has outperformed other models using the Yaseen dataset, reaching an average of 99.80% for accuracy and AUC, respectively. On the other hand, this model can achieve averages of 97.40% and 96.40% for accuracy and AUC, respectively, when the PhysioNet 2016 challenge dataset is used. When the Yaseen dataset is relabeled as normal and abnormal, it reaches 100.0% for both accuracy and AUC. The experiment’s findings indicate that the proposed hybrid AI model can significantly recognize heart sound recordings. This ability is essential for the domain of experts to advise the most effective treatment and prompt further investigation into suspicious cases.

Background: The examination, counting, and classification of white blood cells (WBCs), also known as leukocytes, are essential processes in the diagnosis of many disorders, including leukemia, a kind of blood cancer characterized by the uncontrolled proliferation of carcinogenic leukocytes in the marrow of the bone. Blood smears can be chemically or microscopically studied to better understand hematological diseases and blood disorders. Detecting, identifying, and categorizing the many blood cell types are essential for disease diagnosis and therapy planning. A theoretical and practical issue. However, methods based on deep learning (DL) have greatly helped blood cell classification.Materials and Methods: Images of blood cells in a microscopic smear were collected from GitHub, a public source that uses the MIT license. An end-to-end computer-aided diagnosis (CAD) system for leukocytes has been created and implemented as part of this study. The introduced system comprises image preprocessing and enhancement, image segmentation, feature extraction and selection, and WBC classification. By combining the DenseNet-161 and the cyclical learning rate (CLR), we contribute an approach that speeds up hyperparameter optimization. We also offer the one-cycle technique to rapidly optimize all hyperparameters of DL models to boost training performance.Results: The dataset has been split into two sets: approximately 80% of the data (9,966 images) for the training set and 20% (2,487 images) for the validation set. The validation set has 623, 620, 620, and 624 eosinophil, lymphocyte, monocyte, and neutrophil images, whereas the training set has 2,497, 2,483, 2,487, and 2,499, respectively. The suggested method has 100% accuracy on the training set of images and 99.8% accuracy on the testing set.Conclusion: Using a combination of the recently developed pretrained convolutional neural network (CNN), DenseNet, and the one fit cycle policy, this study describes a technique of training for the classification of WBCs for leukemia detection. The proposed method is more accurate compared to the state of the art.