Prof. Dr. Carla Bazzicalupi

Department of Chemistry, University of Florence, Via della Lastruccia, 3-13 - 50019 Sesto Fiorentino, Florence, Italy

Prof. Dr. Carla Bazzicalupi

Department of Chemistry, University of Florence, Via della Lastruccia, 3-13 - 50019 Sesto Fiorentino, Florence, Italy

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Academic Career Length

34Years (1993-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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29 May 2004 in Inorganic Chemistry

Journal Article

Clioquinol, a Drug for Alzheimer's Disease Specifically Interfering with Brain Metal Metabolism: Structural Characterization of Its Zinc(II) and Copper(II) Complexes

Massimo Di Vaira

Carla Bazzicalupi

Pierluigi Orioli

Luigi Messori

Bruno Bruni

Paolo Zatta

1 April 2011 in Desalination

Journal Article

Mechanism of paracetamol removal by vegetable wastes: The contribution of π–π interactions, hydrogen bonding and hydrophobic effect

1 June 1997 in Inorganic Chemistry

Journal Article

Carboxy and Phosphate Esters Cleavage with Mono- and Dinuclear Zinc(II) Macrocyclic Complexes in Aqueous Solution. Crystal Structure of [Zn₂L1(μ-PP)₂(MeOH)₂](ClO₄)₂ (L1 = [30]aneN₆O₄, PP^- = Diphenyl Phosphate)

Claudia Giorgi

Daniela Zanchi

25 October 2012 in Nucleic Acids Research

Journal Article

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

Francesca Scheggi

The first crystal structure of human telomeric DNA in complex with the natural alkaloid berberine, produced by different plant families and used in folk medicine for millennia, was solved by X-ray diffraction method. The G-quadruplex unit features all-parallel strands. The overall folding assumed by DNA is the same found in previously reported crystal structures. Similarly to previously reported structures the ligand molecules were found to be stacked onto the external 5′ and 3′-end G-tetrads. However, the present crystal structure highlighted for the first time, the presence of two berberine molecules in the two binding sites, directly interacting with each tetrad. As a consequence, our structural data point out a 2:1 ligand to G-tetrad molar ratio, which has never been reported before in a telomeric intramolecular quadruplex structure.

1 July 1999 in Journal of the American Chemical Society

Journal Article

Thermodynamics of Phosphate and Pyrophosphate Anions Binding by Polyammonium Receptors

Mirco Cecchi

Barbara Valtancoli

19 April 2012 in ACS Chemical Biology

Journal Article

Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA

Irene Bessi

Carla Bazzicalupi

Christian Richter

Hendrik R. A. Jonker

Krishna Saxena

Paola Gratteri

About Me

Carla Bazzicalupi, Associate Professor - Department of Chemistry “Ugo Schiff” - University of Florence (Italy). Master degree in Chemistry (1992) and PhD in Chemical Sciences (1996), Italy.Assistant Professor at University of Florence since 2001. Associate Professor (Inorganic Chemistry) at the same University since 2015.Main research interests: structural characterization by means of X-ray diffraction and molecular modelling techniques of supramolecular species.Synthetic receptors, mainly macrocyclic or open polyamines, for the coordination of environmentally and/or biologically relevant species; more recently compounds able to selective interact with non-B DNA, mainly G-quadruplex, structure based drug discovery.Member of the Italian Association of Crystallography (AIC) and of the Società Chimica ItalianaPUBLICATIONS: more than 200 publications in ISI journals, H-index 39 (WoS); 5433 citations (WoS). Orcid number: 0000-0003-4602-0405.

Prof. Dr. Carla Bazzicalupi

Prof. Dr. Carla Bazzicalupi

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