Introduction: Improving well-being and overall system performance are the ultimate goals of ergonomics which are achieved through ergonomic interventions. This systematic review aimed to answer this question: What do the different ergonomic interventions accomplish in a workplace? Method: This systematic review followed the PRISMA guidelines. Ergonomic interventions in workplaces focusing on any ergonomics health outcomes or productivity were identified in electronic databases up to 1 Jun, 2019. Results: The 1635 articles collected from the literature screening stage were screened for their relevance to this study by the authors independently. The full-text review identified 22 papers qualified for inclusion in this systematic review. Most of the interventions implemented in the analyzed articles were ergonomic training programs, participatory ergonomics and workstation designs. The highlight results showed that interventions such as feedback, participatory ergonomics in short term follow-ups, and job rotation along with ergonomic guidelines, did not significantly affect the risk of psychosocial factors. A significant reduction of musculoskeletal disorders in the upper limbs was reported with workplace improvements. Conclusion: There was no specific study method or intervention approach found to influence ergonomic outcomes. A multicomponent intervention program can be used to improve the impact of interventions on employees’ health and system productivity.