We identified Basigin (BSG, EMMPRIN, CD147) to be induced in human epidermal keratinocytes (KC) using pro-aging stress and replicative senescence | POSTER
Skin as a barrier separates and protects organism from its surrounding. A wide range of stressors from the environment (UV radiation, pollution) challenges skin homeostasis and prolonged imbalance accelerates skin aging. Aged skin is characterized by presence of senescent cells, which have changed appearance and phenotype, accumulate damaged biomolecules (DNA, proteome, lipidome)