Mariangela Cernera

Dr. Mariangela Cernera

department of neuroscience, reproductive and odontostomotological sciences, University of Naples Federico II, Naples, Campania, Italy
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Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 February 2026 in Polymers
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Angelo AlibertiAngelo Aliberti
Angelo Aliberti
MCMario Caggiano
Mario Caggiano
MPMirko Piscopo
Mirko Piscopo
Roberta GasparroRoberta Gasparro
Roberta Gasparro
Mariangela CerneraMariangela Cernera
Mariangela Cernera
PIETRO AUSIELLOPIETRO AUSIELLO
PIETRO AUSIELLO
Finite element analysis (FEA) is increasingly used in conservative and restorative dentistry to investigate the mechanical behavior of adhesive direct and indirect polymer-based restorations. Despite the growing number of FEA-based studies, the literature currently lacks a dedicated critical synthesis specifically addressing the methodological validity and clinical interpretability of FEA in adhesive restorative dentistry. This narrative review critically examines the current literature on the application of FEA in adhesive restorative dentistry, with particular attention to class I to class V cavities in anterior and posterior teeth restored with direct or indirect polymeric materials, including inlays, onlays, overlays, and tabletop restorations. A structured, non-systematic search of major databases was conducted, and selected studies were qualitatively appraised with emphasis on modeling assumptions, stress distribution, and clinical meaning. Unlike previous broad overviews of dental biomechanics, this review provides a clinically oriented framework for interpreting FEA findings across restorative strategies. FEA consistently identifies trends related to cavity configuration, cuspal support, restoration design, material stiffness, polymerization shrinkage, and adhesive interface behavior, helping to explain clinically observed failure patterns and supporting minimally invasive approaches. However, simplified material models, idealized bonding conditions, and static loading protocols limit prediction of long-term performance. When interpreted within these constraints and integrated with experimental and clinical evidence, FEA remains a valuable complementary tool for rational restorative decision-making.

27 August 2022 in BioMed Research International
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SNSara Naim
Sara Naim
Gianrico SpagnuoloGianrico Spagnuolo
Gianrico Spagnuolo
EOEssam Osman
Essam Osman
SMSyed Sarosh Mahdi
Syed Sarosh Mahdi
GOPI BATTINENIGOPI BATTINENI
GOPI BATTINENI
CZCarina Mehanna Zogheib
Carina Mehanna Zogheib
Objective. This study is aimed at determining two main points. First, if the Canary System™ (CS), initially used to assess caries, can measure a decalcification depth of bleached enamel quantitatively, and second, whether or not whitening has a harmful effect on enamel. This device can be considered a useful tool in the clinical assessment of the progression of demineralization after bleaching. Materials and Methods. This study collected sixty human premolars that are in a good state recently extracted for orthodontic reason. To properly disinfect and preserve the premolars, they were stored in a saline solution and later in distilled water for a period of two weeks to allow the premolars to rehydrate. Later, 24 hours before the experiment, the premolars were introduced into a solution of artificial saliva to acquire back their minerals. The mineral content of the teeth was measured by the Canary System™ before bleaching. The teeth were bleached with 30% hydrogen peroxide (fläsh HP 30%), 30 min per week and for 3 consecutive weeks to simulate the conditions of strong bleaching in the clinic. The extent of demineralized enamel was measured by the Canary System™ at three points on the enamel surface of each tooth. The data were averaged for each application of the bleaching product. The demineralization extent of the teeth was measured by the Canary System™ before and after bleaching. The significance level was set at 0.05, and SPSS version 26 was used. The data were analyzed by using Wilcoxon’s and Student’s tests. Results. Mineral loss occurred after the first bleaching session; the Canary System™ detected a decalcification in the first bleaching session (532 ± 322 μm) compared to the other sessions (p ≤ 0.05), while no significant change was detected between the second and the third sessions (p > 0.05). Conclusion. Based on the findings of the present study, under in vitro conditions, it was possible to measure the demineralization extent of bleached enamel with the Canary System™.

6 January 2023 in Applied Sciences
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KRKeerthika Rajamanickam
Keerthika Rajamanickam
KTKavalipurapu Venkata Teja
Kavalipurapu Venkata Teja
SRSindhu Ramesh
Sindhu Ramesh
Sahil ChoudhariSahil Choudhari
Sahil Choudhari
Mariangela CerneraMariangela Cernera
Mariangela Cernera
Gianrico SpagnuoloGianrico Spagnuolo
Gianrico Spagnuolo
Root canal preparation generates inorganic and organic tissue debris. Various irrigation techniques are used to remove the smear layer from the root canal system. The present study aimed to evaluate canal cleanliness using a novel irrigation device with ultrasonic and manual irrigation in extracted teeth. Twenty-one freshly extracted single-rooted teeth with specified inclusion and exclusion criteria were collected for the present study. The specimens were prepared to a size using a rotary file to size 30 and 6% taper preparation. The specimens were then divided into three groups: group I, Manual irrigation group (n = 7), group II, Automated irrigation (n = 7), group III, Passive ultrasonic irrigation (n = 7). Following the experimental irrigation, the teeth were subjected to the scanning electron microscopy (SEM). Statistically significant reduction (p < 0.05) in both smear layer and debris scores were seen in group III as compared to the other groups. Based on Hülsmann’s scoring method, it was found that the automated root canal irrigation device showed better canal cleanliness when compared with the manual irrigation technique but was less effective than passive ultrasonic irrigation.

21 December 2022 in Dentistry Journal
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NANiccoló Giuseppe Armogida
Niccoló Giuseppe Armogida
Carlo RengoCarlo Rengo
Carlo Rengo
Mariangela CerneraMariangela Cernera
Mariangela Cernera
FIFlavia Iaculli
Flavia Iaculli
Gianrico SpagnuoloGianrico Spagnuolo
Gianrico Spagnuolo
Gingival melanin hyperpigmentation is a para-physiological condition that may have a negative impact on smile esthetics. In the present study, the use of the Q-Switched Nd:YAG laser, according to a defined protocol, was proposed to treat Gingival Melanin Hyperpigmentation with a transepithelial approach. A total of 10 Patients with different grades of gingival hyperpigmentation were treated with Q-Switched Nd:YAG in one to four laser sessions without local anesthesia. The grade of depigmentation was evaluated by comparing Oral Pigmentation Index (OPI) and Melanin Pigmentation Index (MPI) at baseline and three weeks after the laser session. Additionally, oral discomfort rated by the Numeric Rating Scale (NRS) was recorded one, three, and five days after the procedure. Complete depigmentation was achieved in all cases. Patients reported no-little discomfort (NRS 0 to 3) during the laser session that lasted a maximum of five days. No major complications were reported, and no recurrences were observed at least after one year of follow-up. In addition, patients were available to be re-treated if necessary. These findings suggested that the Q-Switched Nd:YAG could be an effective and well-tolerated approach in the treatment of gingival melanin hyperpigmentation.

26 August 2021 in International Journal of Dentistry
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AMAmirhossein Moaddabi
Amirhossein Moaddabi
PSParisa Soltani
Parisa Soltani
MZMaryam Zamanzadeh
Maryam Zamanzadeh
KNKamran Nosrati
Kamran Nosrati
MMMojtaba Mollamirzaei
Mojtaba Mollamirzaei
Gianrico SpagnuoloGianrico Spagnuolo
Gianrico Spagnuolo
Background. Many dental procedures begin with local anesthesia. Subsequent increase in blood pressure in healthy individuals commonly occurs and may be affected by several factors such as mental and physical stress, painful stimuli, and action of catecholamines present in local anesthetic solutions. The aim of the present study is to compare the effects of 4% articaine with 1 : 100000 epinephrine and 2% lidocaine with 1 : 80000 epinephrine on blood pressure after maxillary infiltration technique. Materials and Methods. In this randomized clinical trial, 102 patients were randomly assigned into two groups. One group received 4% articaine with 1 : 100000 epinephrine and the other group received 2% lidocaine with 1 : 80000 epinephrine for local maxillary infiltration. Systolic and diastolic blood pressure of both groups was determined twice: once before anesthetic injection and once 10 minutes after injection. The data were statistically analyzed using descriptive statistics, Shapiro–Wilks test, Levene test, chi-square test, independent t-test, and paired t-test. Results. The mean systolic blood pressure after anesthetic injection in the articaine and lidocaine groups was 125.00 ± 5.67 and 123.16 ± 6.417 mmHg, respectively, showing no statistically significant difference ( ). The mean diastolic blood pressure after injection was 85.02 ± 7.331 in the articaine group and 81.35 ± 12.815 mmHg in the lidocaine group. These values show no statistically significant difference ( ). In both groups, the mean systolic and diastolic blood pressures have increased significantly ( ). Conclusion. Articaine can be regarded as a suitable alternative for lidocaine for maxillary local infiltration, as no significant difference was observed between the effects of the two anesthetic solutions on blood pressure.

Verified
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LSLiliana Szyszka-Sommerfeld
Liliana Szyszka-Sommerfeld
MSMagdalena Sycińska-Dziarnowska
Magdalena Sycińska-Dziarnowska
Mariangela CerneraMariangela Cernera
Mariangela Cernera
LELuigi Esposito
Luigi Esposito
KWKrzysztof Woźniak
Krzysztof Woźniak
Gianrico SpagnuoloGianrico Spagnuolo
Gianrico Spagnuolo
Background: Surface electromyography (sEMG) can provide an objective and quantitative image of the functional state of neuromuscular balance in the stomatognathic system. The objective of this systematic review is to examine current scientific evidence regarding the effects of orthodontic treatment on muscle electromyographic (EMG) activity in children. Methods: The search strategy included the PubMed, PubMed Central, Web of Science, Scopus, and Embase databases. The inclusion criteria were studies assessing EMG muscle activity in children undergoing orthodontic treatment compared with untreated children. The Cochrane risk-of-bias tool (RoB2) and the Newcastle–Ottawa Scale (NOS) were used to evaluate the quality of the studies. The quality of evidence assessment was performed using GRADE analysis. The PRISMA diagram visually represented the search strategy, as well as screening and inclusion process. Results: The search strategy identified 540 potential articles. Fourteen papers met the inclusion criteria. Six studies were judged at a low risk of bias. The certainty of evidence was rated as moderate to low, according to the GRADE criteria. Studies showed alterations in EMG muscle activity in children undergoing orthodontic treatment. Conclusions: Orthodontic treatment appears to affect muscle activity in children undergoing orthodontic treatment. However, the quality of evidence is low and, therefore, it is not possible to definitively state this effect. Further long-term studies are needed to confirm the findings of this review. Study protocol number in PROSPERO database: CRD42023491005.