Cancer accounts for a huge mortality rate due to its aggressiveness, colossal potential of metastasis, and heterogeneity (causing resistance against chemotherapy). Lung and colon cancers are among the most prevalent types of cancer around the globe that can occur in both males and females. Early and accurate diagnosis of these cancers can substantially improve the quality of treatment as well as the survival rate of cancer patients. We propose a highly accurate and computationally efficient model for the swift and accurate diagnosis of lung and colon cancers as an alternative to current cancer detection methods. In this study, a large dataset of lung and colon histopathology images was employed for training and the validation process. The dataset is comprised of 25000 histopathology images of lung and colon tissues equally divided into 5 classes. A pretrained neural network (AlexNet) was tuned by modifying the four of its layers before training it on the dataset. Initial classification results were promising for all classes of images except for one class with an overall accuracy of 89%. To improve the overall accuracy and keep the model computationally efficient, instead of implementing image enhancement techniques on the entire dataset, the quality of images of the underperforming class was improved by applying a contrast enhancement technique which is fairly simple and efficient. The implementation of the proposed methodology has not only improved the overall accuracy from 89% to 98.4% but has also proved computationally efficient.

Bone tumors, such as osteosarcomas, can occur anywhere in the bones, though they usually occur in the extremities of long bones near metaphyseal growth plates. Osteosarcoma is a malignant lesion caused by a malignant osteoid growing from primitive mesenchymal cells. In most cases, osteosarcoma develops as a solitary lesion within the most rapidly growing areas of the long bones in children. The distal femur, proximal tibia, and proximal humerus are the most frequently affected bones, but virtually any bone can be affected. Early detection can reduce mortality rates. Osteosarcoma’s manual detection requires expertise, and it can be tedious. With the assistance of modern technology, medical images can now be analyzed and classified automatically, which enables faster and more efficient data processing. A deep learning-based automatic detection system based on whole slide images (WSIs) is presented in this paper to detect osteosarcoma automatically. Experiments conducted on a large dataset of WSIs yielded up to 99.3% accuracy. This model ensures the privacy and integrity of patient information with the implementation of blockchain technology. Utilizing edge computing and fog computing technologies, the model reduces the load on centralized servers and improves efficiency.

A major and essential issue in biomedical research is to predict genome disorder. Genome disorders cause multivariate diseases like cancer, dementia, diabetes, cystic fibrosis, leigh syndrome, etc. which are causes of high mortality rates around the world. In past, theoretical and explanatory-based approaches were introduced to predict genome disorder. With the development of technology, genetic data were improved to cover almost genome and protein then machine and deep learning-based approaches were introduced to predict genome disorder. Parallel machine and deep learning approaches were introduced. In past, many types of research were conducted on genome disorder prediction using supervised, unsupervised, and semi-supervised learning techniques, most of the approaches using binary problem prediction using genetic sequence data. The prediction results of these approaches were uncertain because of their lower accuracy rate and binary class prediction techniques using genome sequence data but not genome disorder patients’ data with his/her history. Most of the techniques used Ribonucleic acid (RNA) gene sequence and were not often capable of handling bid data effectively. Consequently, in this study, the AlexNet as an effective convolutional neural network architecture proposed to develop an advance genome disorder prediction model (AGDPM) for predicting genome multi classes disorder using a large amount of data. AGDPM tested and compare with the pre-trained AlexNet neural network model and AGDPM gives the best results with 89.89% & 81.25% accuracy of training and testing respectively. So, the advance genome disorder prediction model shows the ability to efficiently predict genome disorder and can process a large amount of patients’ genome disorder data with a multi-class prediction method. AGDPM has proved that it is capable to predict single gene inheritance disorder, mitochondrial gene inheritance disorder, and multifactorial gene inheritance disorder with respect to various statistical performance parameters. So, with the help of AGDPM biomedical research will be improved in terms to predict genetic disorders and put control on high mortality rates.

The study presents a framework to analyze and detect meddling in real-time network data and identify numerous meddling patterns that may be harmful to various communication means, academic institutes, and other industries. The major challenge was to develop a non-faulty framework to detect meddling (to overcome the traditional ways). With the development of machine learning technology, detecting and stopping the meddling process in the early stages is much easier. In this study, the proposed framework uses numerous data collection and processing techniques and machine learning techniques to train the meddling data and detect anomalies. The proposed framework uses support vector machine (SVM) and K-nearest neighbor (KNN) machine learning algorithms to detect the meddling in a network entangled with blockchain technology to ensure the privacy and protection of models as well as communication data. SVM achieves the highest training detection accuracy (DA) and misclassification rate (MCR) of 99.59% and 0.41%, respectively, and SVM achieves the highest-testing DA and MCR of 99.05% and 0.95%, respectively. The presented framework portrays the best meddling detection results, which are very helpful for various communication and transaction processes.