Erosion wear is a common failure form of slotted screen in service. In this paper, based on CFD software and sand production data of a gas field in the Tarim Basin, the particle velocity and shear force at the slot of the flow field in the sieve tube were studied to determine the maximum area of erosion; at the same time, the velocity, viscosity, particle size and concentration of sand-carrying fluid were analyzed by orthogonal test, and the regression model of multi-factor maximum erosion rate was established. ① Through the analysis of the four factors on the degree of dependent variables, the order of the primary and secondary factors are: sand-carrying liquid flow rate, particle concentration, fluid viscosity, particle diameter, the effect of fluid viscosity and particle diameter on erosion rate is relatively small; ② According to the analysis of variance and range, the combination scheme of minimum erosion generation is obtained, and the calculation model of the erosion rate of the slotted screen is established. In order to reduce the erosion and abrasion in the actual oil and gas production process, the reasonable flow control and precise sand control method design and precision selection can be adopted; it provides a design basis for sand control and long-term effects of production in high-yield gas field.