The fact that dietary restriction (DR) and long-term rapamycin treatment (RALL) can ameliorate the aging process has been reported by many researchers. As the interface between external and genetic factors, epigenetic modification such as DNA methylation may have latent effects on the aging rate at the molecular level. To understand the mechanism behind the impacts of dietary restriction and rapamycin on aging, DNA methylation and gene expression changes were measured in the hippocampi of different-aged mice. Examining the single-base resolution of DNA methylation, we discovered that both dietary restriction and rapamycin treatment can maintain DNA methylation in a younger state compared to normal-aged mice. Through functional enrichment analysis of genes in which DNA methylation or gene expression can be affected by DR/RALL, we found that DR/RALL may retard aging through a relationship in which DNA methylation and gene expression work together not only in the same gene but also in the same biological process. This study is instructive for understanding the maintenance of DNA methylation by DR/RALL in the aging process, as well as the role of DR and RALL in the amelioration of aging.

With the advent of the era of rapid information expansion, the massive data backlog that exists on the Internet has led to a serious information overload problem, which makes recommendation systems a crucial part of human life. In particular, the Point-Of-Interest (POI) recommendation system has been applied to many real-life scenarios, such as life services and autonomous driving. Specifically, the goal of POI recommendation is to recommend locations that match their personalized preferences to users. In existing POI recommendation methods, people tend to pay more attention to the impact of temporal and spatial factors of POI on users, which will alleviate the problems of data sparsity and cold start in POI recommendation. However, this tends to ignore the differences among individual users, and considering only temporal and spatial attributes does not support fine-grained POI recommendations. To solve this problem, we propose a new Fine-grained POI Recommendation With Multi-Graph Convolutional Network (FP-MGCN). This model focuses on the content representation of POIs, captures users’ personalized preferences using semantic information from user comments, and learns fine-grained representations of users and POIs through the relationships between content–content, content–POI, and POI–user. FP-MGCN employs multiple embedded propagation layers and adopts information propagation mechanisms to model the higher-order connections of different POI-related relations for enhanced representation. Fine-grained POI is finally recommended to users through the three types of propagation we designed: content–content information propagation, content–POI information propagation, and POI–user information propagation. We have conducted detailed experiments on two datasets, and the results show that FP-MGCN has advanced performance and can alleviate the data sparsity problem in POI recommendation tasks.

Personalized recipe recommendation is attracting more and more attention, which can help people make choices from the exploding growth of online food information. Unlike other recommendation tasks, the target of recipe recommendation is a non-atomic item, so attribute information is especially important for the representation of recipes. However, traditional collaborative filtering or content-based recipe recommendation methods tend to focus more on user–recipe interaction information and ignore higher-order semantic and structural information. Recently, graph neural networks (GNNs)-based recommendation methods provided new ideas for recipe recommendation, but there was a problem of sparsity of supervised signals caused by the long-tailed distribution of heterogeneous graph entities. How to construct high-quality representations of users and recipes becomes a new challenge for personalized recipe recommendation. In this paper, we propose a new method, a multi-level knowledge-aware contrastive learning network (MKCLN) for personalized recipe recommendation. Compared with traditional comparative learning, we design a multi-level view to satisfy the requirement of fine-grained representation of users and recipes, and use multiple knowledge-aware aggregation methods for node fusion to finally make recommendations. Specifically, the local-level includes two views, interaction view and semantic view, which mine collaborative information and semantic information for high-quality representation of nodes. The global-level learns node embedding by capturing higher-order structural information and semantic information through a network structure view. Then, a kind of self-supervised cross-view contrastive learning is invoked to make the information of multiple views collaboratively supervise each other to learn fine-grained node embeddings. Finally, the recipes that satisfy personalized preferences are recommended to users by joint training and model prediction functions. In this study, we conduct experiments on two real recipe datasets, and the experimental results demonstrate the effectiveness and advancement of MKCLN.

This paper presents a twisting controller (TC) based on a high-order sliding mode observer (HOSMO) for linear induction motors (LIMs), accounting for dynamic end effects. Based on the LIM model in the field-oriented frame, two extended subsystems are developed: a velocity extended model and a flux extended model. Using these models, two HOSMOs are designed to estimate the disturbances in each subsystem. The HOSMO outputs are then used for disturbance rejection, resulting in two second-order systems with small bounded disturbances. Two TCs are subsequently implemented to achieve finite-time velocity and flux tracking of the LIM. The primary advantage of this strategy lies in its ability to reduce chattering through active disturbance rejection. Hardware-in-the-loop (HIL) experiments validate the effectiveness of the proposed TC-HOSMO scheme.

With the rapid development of online social networks recently, more and more online users have participated in social network activities and rich social relationships are formed accordingly. These social relationships provide a rich data source and research basis for in-depth study on recommender systems (RSs), while also promoting the development of RSs based on social networks. To solve the problems of cold start and sparsity in RSs, many recommendation algorithms are constantly being proposed. Motivated by the availability of rich social connections in today’s RSs, a large number of recommendation techniques based on social relationships have been proposed recently, achieving good recommendation results, and have become the mainstream research direction in the field of RSs, attracting more and more researchers to engage in this research. In this study, we mainly review and summarize the social relationship-based recommendation methods and techniques in RSs, and study some recent deep social relationship recommendation methods and techniques based on deep learning (DL), including the latest social matrix factorization (MF)-based recommendation methods and graph neural network (GNN)-based recommendation methods. Finally, we discuss the potential impact that may improve the RS and future direction. In this article, we aim to introduce the recent recommendation techniques integrating social relationships to solve data sparsity and cold start, and provide a new perspective for improving the performance of RSs, thereby providing useful resources in the state-of-the-art research results for future researchers.