Positioning and location tracking are two major needs of the modern era; in which logistics, industry automation, smart buildings/cities and the Internet of Things concepts are trending topics and are constantly evolving. Introduction of the Global Positioning System (GPS) solved the issue well for outdoor scenarios, however, it is not a reliable solution for indoors, where satellite communication (line-of-sight in general) cannot be maintained. Additionally, there are usually many obstructions (i.e. walls), which block or distort the signals or many signal sources causing interference and noise. Thus, indoor positioning requires different and smarter approaches. iBeacon, is new device-to-device communication technology that relies on Bluetooth Low Energy. In this work, we tested accuracy of a known method used to estimate the distance between two devices communicating through the iBeacon technology. Moreover; effects of the output power, placement of the devices, existence of walls and the possible radio interference, on the accuracy of that distance estimation are investigated.

Characterizing all possible side effects of compounds is not a trivial task due to unknown off-target proteins that might eventually lead lethal reactions. There is still a tremendous need of computational methods to identify protein targets of a new compound. We have performed a comprehensive analysis for identification of protein targets by integrating tissue-specific protein-protein interaction (PPI) networks and compound induced transcriptome data. Several network centrality metrics are computed to suggest the most probable off-targets of a given compound. The effects of interaction types between proteins and tissue-specific PPI networks are evaluated from multiple perspectives. Usage of network centrality metrics on a tissue-specific PPI network enhances the correct prediction rate of known targets of a given compound. The detailed analysis of successfully identified known targets indicated that degree and local radiality metrics are more practical for determining different types of target protein families, such as GPCR, chemokines, proteasome, and protein kinase families. Therefore, the proposed computational pipeline is applicable while investigating proteins from these families that can be especially targeted for treatment of complex diseases. To the best of our knowledge, this study for the first time presents how tissue-specific transcriptome changes alter the topological structure of PPI networks and the relative effects of tissue-specific networks in target identification. Overall, the proposed computational methods are practical tools for choosing more accurate protein targets for later computational analysis and wet-lab experiments.

Planning a journey by integrating route and timetable information from diverse sources of transportation agencies such as bus, ferry, and train can be complicated. A user-friendly, informative journey planning system may simplify a plan by providing assistance in making better use of public transportation. In this study, we presented the service-oriented, multimodel Intelligent Journey Planning System, which we developed to assist travelers in journey planning. We selected Izmir, Turkey, as the pilot city for this system. The multicriteria problem is one of the well-known problems in transportation networks. Our study proposes a gradual path-finding algorithm to solve this problem by considering transfer count and travel time. The algorithm utilizes the techniques of efficient algorithms including round based public transit optimized router, transit node routing, and contraction hierarchies on transportation graph. We employed Dijkstra’s algorithm after the first stage of the path-finding algorithm by applying stage specific rules to reduce search space and runtime. The experimental results show that our path-finding algorithm takes 0.63 seconds of processing time on average, which is acceptable for the user experience.