Doriano Lamba

Dr. Doriano Lamba

Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Trieste Outstation, Area Science Park, Basovizza, S.S. n°14 Km 163.5, I-34149 Trieste, Italy
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Research Focus & Metrics

Academic Career Length

44Years (1983-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2003 in Journal of Molecular Biology
Verified
Journal Article
Closed access
ZMZora Marković-Housley
Zora Marković-Housley
MDMassimo Degano
Massimo Degano
Doriano LambaDoriano Lamba
Doriano Lamba
EREdda von Roepenack-Lahaye
Edda von Roepenack-Lahaye
SCStephan Clemens
Stephan Clemens
HBHeimo Breiteneder
Heimo Breiteneder

3 December 2001 in The EMBO Journal
Verified
Journal Article
Open access
PDF file
DTDusan Turk
Dusan Turk
VJVojko Janjić
Vojko Janjić
IŠIgor Štern
Igor Štern
MPMarjetka Podobnik
Marjetka Podobnik
Doriano LambaDoriano Lamba
Doriano Lamba
BTBoris Turk
Boris Turk
Dipeptidyl peptidase I (DPPI) or cathepsin C is the physiological activator of groups of serine proteases from immune and inflammatory cells vital for defense of an organism. The structure presented shows how an additional domain transforms the framework of a papain‐like endopeptidase into a robust oligomeric protease‐processing enzyme. The tetrahedral arrangement of the active sites exposed to solvent allows approach of proteins in their native state; the massive body of the exclusion domain fastened within the tetrahedral framework excludes approach of a polypeptide chain apart from its termini; and the carboxylic group of Asp1 positions the N‐terminal amino group of the substrate. Based on a structural comparison and interactions within the active site cleft, it is suggested that the exclusion domain originates from a metallo‐protease inhibitor. The location of missense mutations, characterized in people suffering from Haim–Munk and Papillon–Lefevre syndromes, suggests how they disrupt the fold and function of the enzyme.

12 March 2015 in The European Physical Journal Plus
Verified
Journal Article
Closed access
PDF file
ALA. Lausi
A. Lausi
MPM. Polentarutti
M. Polentarutti
SOSilvia Onesti
Silvia Onesti
JPJasper Plaisier
Jasper Plaisier
EBE. Busetto
E. Busetto
GPG. Paolucci
G. Paolucci

10 October 2014 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
Eugenie  NepovimovaEugenie Nepovimova
Eugenie Nepovimova
EUElisa Uliassi
Elisa Uliassi
Jan KorabecnyJan Korabecny
Jan Korabecny
LPLuis Emiliano Peña-Altamira
Luis Emiliano Peña-Altamira
SSSarah Samez
Sarah Samez
MBMaria Laura Bolognesi
Maria Laura Bolognesi

5 December 2000 in Proteins: Structure, Function, and Bioinformatics
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Journal Article
Closed access
PDF file
CBCecilia Bartolucci
Cecilia Bartolucci
EPEmanuele Perola
Emanuele Perola
CPChristian Pilger
Christian Pilger
GFGregor Fels
Gregor Fels
Doriano LambaDoriano Lamba
Doriano Lamba

1 April 1996 in Journal of Molecular Biology
Verified
Journal Article
Closed access
Doriano LambaDoriano Lamba
Doriano Lamba
MBMargit Bauera
Margit Bauera
RHRobert Hubera
Robert Hubera
SFStephan Fischerb
Stephan Fischerb
RRRainer Rudolphb
Rainer Rudolphb
WBWolfram Bodea
Wolfram Bodea