Yan Deng

Yan Deng


Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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30 May 2017 in Bone Research
Verified
Journal Article
Open access
PDF file
MLMei Liu
Mei Liu
XZXin Zeng
Xin Zeng
CMChao Ma
Chao Ma
HYHuan Yi
Huan Yi
ZAZeeshan Ali
Zeeshan Ali
Nongyue HeNongyue He
Nongyue He
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.

1 June 2021 in Journal of Nanobiotechnology
Verified
Journal Article
Open access
PDF file
WGWenfei Guo
Wenfei Guo
CZChuanxiang Zhang
Chuanxiang Zhang
TMTingting Ma
Tingting Ma
XLXueying Liu
Xueying Liu
ZCZhu Chen
Zhu Chen
YDYan Deng
Yan Deng
Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.

1 April 2019 in Biosensors and Bioelectronics
Verified
Journal Article
Closed access
MLMei Liu
Mei Liu
AKArshad Khan
Arshad Khan
ZWZhifei Wang
Zhifei Wang
YLYuan Liu
Yuan Liu
GYGaojian Yang
Gaojian Yang
Nongyue HeNongyue He
Nongyue He

1 September 2019 in Biosensors and Bioelectronics
Verified
Journal Article
Closed access
GYGaojian Yang
Gaojian Yang
ZXZiqi Xiao
Ziqi Xiao
CTCongli Tang
Congli Tang
YDYan Deng
Yan Deng
HHHao Huang
Hao Huang
ZHZiyu He
Ziyu He

21 April 2020 in Journal of Nanobiotechnology
Verified
Journal Article
Open access
PDF file
CTCongli Tang
Congli Tang
ZHZiyu He
Ziyu He
HLHongmei Liu
Hongmei Liu
YXYuyue Xu
Yuyue Xu
HHHao Huang
Hao Huang
Nongyue HeNongyue He
Nongyue He
Nucleic acid is the main material for storing, copying, and transmitting genetic information. Gene sequencing is of great significance in DNA damage research, gene therapy, mutation analysis, bacterial infection, drug development, and clinical diagnosis. Gene detection has a wide range of applications, such as environmental, biomedical, pharmaceutical, agriculture and forensic medicine to name a few. Compared with Sanger sequencing, high-throughput sequencing technology has the advantages of larger output, high resolution, and low cost which greatly promotes the application of sequencing technology in life science research. Magnetic nanoparticles, as an important part of nanomaterials, have been widely used in various applications because of their good dispersion, high surface area, low cost, easy separation in buffer systems and signal detection. Based on the above, the application of magnetic nanoparticles in nucleic acid detection was reviewed.

27 October 2016 in Science China Chemistry
Verified
Journal Article
Closed access
PDF file
YLYuan Liu
Yuan Liu
YDYan Deng
Yan Deng
HDHongming Dong
Hongming Dong
KLKeke Liu
Keke Liu
Nongyue HeNongyue He
Nongyue He