Quantitative probability has been computed for the tsunami hazard posed by earthquakes from the Manila Trench, which has been regarded as a huge threat in the South China Sea. This study provides a spatial distribution of the tsunami hazard covering the affected area with a spatial resolution of 0.1° for disaster prevention of islands and continental coasts. The quantitative probability of the tsunami hazard is computed by an efficient model, which can realize a large amount of potential tsunami scenarios analysis in order to consider the randomness and uncertainty in earthquake magnitude, source location and focal depth. In the model, for each potential tsunami scenario, the occurrence probability of the corresponding earthquake and the intensity of tsunami waves at each target location are computed. The occurrence probability of each scenario is estimated based on the historical earthquake records. Then, the subsequent tsunami caused by each scenario is computed using a new, efficient approach, instead of direct simulation using an ocean dynamics model. A total of 1,380,000 scenarios are computed in order to obtain a stable statistical result. Based on the results, the spatial distribution of the tsunami hazard is discussed and high-hazard regions along the coast have been identified.