Deltaic channels are significant landforms at the interface of sediment transfer from land to oceanic realms. Understanding the dynamics of these channels is urgent because delta processes are sensitive to climate change and adjustments in human activity. To obtain a better understanding of the morphological processes of large deltaic channels, this study assessed the evolution and response mechanism of the South Channel and South Passage (SCSP) in the Yangtze Estuary between 1983 to 2018 using hydrology, multibeam echo sounding and historical bathymetry datasets. Decadal changes in riverbed volume and erosion/deposition patterns in the SCSP were assessed. The results showed that the SCSP experienced substantial deposition with a total volume of 26.90 × 10⁷ m³ during 1983–2002, but significant bed erosion with a total volume of 26.04 ×10⁷ m³ during 2003–2010. From 2011 to 2018, the estuarine riverbeds shifted from erosive to depositional, even though the deposition was relatively marginal (0.76 ×10⁷ m³). We inferred that the SCSP have most likely changed from a net erosion phase to a deposition stage in response to local human activities including sand mining, river regulation project, and Deep Water Channel Regulation Project). The channel aggradation will possibly continue considering sea level rise and the ongoing anthropogenic impacts. This is the first field evidence reporting that the lowermost Yangtze River is reaching an equilibrium state in terms of channel erosion and, in fact, the Yangtze River Estuary channels are beginning to aggrade. The findings have relevant implications for the management of the Yangtze River and other lowland alluvial rivers in the world as global sea level continues rising and human intervention on estuarine systems persists.