Understanding the temporal and spatial patterns of flood in the Awash River basin, which is located in Ethiopia’s Afar region, is crucial. The Awash basin was picked because it is continuously in danger both spatially and temporally. The likelihood of flooding was assessed using eight independent variables: elevation, slope, rainfall, drainage density, land use, soil type, wetness index, and lineament density. Each constituent was assigned a weight based on its susceptibility to the danger, which was classified into four classifications. Exploratory regression analysis showed that the existing land use is the main factor influencing flood susceptibility. For the GIS domain, a total of 31 models were built using exploratory regression. Model number 31 was found to be the best fit model, having the highest Adjusted R² value of 0.8 and the lowest Akaike’s Information criterion value of 1536.8. The spatial autocorrelation tool’s Z score and p-value for the standard residuals are, respectively, 0.7 and 0.4, indicating that they were neither clustered nor scattered. The geographic breadth of flood susceptibility and risk is thoroughly examined in this paper, as is the significance of spatial planning in the Awash basin.