Alessio Gnerucci

Dr. Alessio Gnerucci

Physics and Astronomy, Università degli Studi di Firenze, Florence, Tuscany, Italy
orcid

Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 December 2014 in Journal of Nanobiotechnology
Verified
Journal Article
Open access
PDF file
SCSonia Centi
Sonia Centi
FTFrancesca Tatini
Francesca Tatini
FRFulvio Ratto
Fulvio Ratto
AGAlessio Gnerucci
Alessio Gnerucci
RMRaffaella Mercatelli
Raffaella Mercatelli
RPRoberto Pini
Roberto Pini
The interest for gold nanorods in biomedical optics is driven by their intense absorbance of near infrared light, their biocompatibility and their potential to reach tumors after systemic administration. Examples of applications include the photoacoustic imaging and the photothermal ablation of cancer. In spite of great current efforts, the selective delivery of gold nanorods to tumors through the bloodstream remains a formidable challenge. Their bio-conjugation with targeting units, and in particular with antibodies, is perceived as a hopeful solution, but the complexity of living organisms complicates the identification of possible obstacles along the way to tumors. Here, we present a new model of gold nanorods conjugated with anti-cancer antigen 125 (CA125) antibodies, which exhibit high specificity for ovarian cancer cells. We implement a battery of tests in vitro, in order to simulate major nuisances and predict the feasibility of these particles for intravenous injections. We show that parameters like the competition of free CA125 in the bloodstream, which could saturate the probe before arriving at the tumors, the matrix effect and the interference with erythrocytes and phagocytes are uncritical. Although some deterioration is detectable, anti-CA125-conjugated gold nanorods retain their functional features after interaction with blood tissue and so represent a powerful candidate to hit ovarian cancer cells.

2 October 2020 in Mathematical Biosciences
Verified
Journal Article
Closed access
AGAlessio Gnerucci
Alessio Gnerucci
PFPaola Faraoni
Paola Faraoni
ESElettra Sereni
Elettra Sereni
FRFrancesco Ranaldi
Francesco Ranaldi

13 October 2022 in Strahlentherapie und Onkologie
Verified
Journal Article
Closed access
PDF file
AGAlessio Gnerucci
Alessio Gnerucci
MEM. Esposito
M. Esposito
AGA. Ghirelli
A. Ghirelli
SPS. Pini
S. Pini
LPL. Paoletti
L. Paoletti
SRS. Russo
S. Russo

28 June 2023 in Strahlentherapie und Onkologie
Verified
Journal Article
Closed access
PDF file
AGAlessio Gnerucci
Alessio Gnerucci
MEM. Esposito
M. Esposito
AGA. Ghirelli
A. Ghirelli
SPS. Pini
S. Pini
LPL. Paoletti
L. Paoletti
SRS. Russo
S. Russo

14 March 2024 in Microchemical Journal
Verified
Journal Article
Open access
LQLorenzo Quadrini
Lorenzo Quadrini
ESEmma Salvadori
Emma Salvadori
SLSerena Laschi
Serena Laschi
MVMargherita Verrucchi
Margherita Verrucchi
AGAlessio Gnerucci
Alessio Gnerucci
Ilaria PalchettiIlaria Palchetti
Ilaria Palchetti

1 July 2016 in Physica Medica
Verified
Journal Article
Closed access
AGAlessio Gnerucci
Alessio Gnerucci
GRGiovanni Romano
Giovanni Romano
FRFulvio Ratto
Fulvio Ratto
SCSonia Centi
Sonia Centi
MBMichela Baccini
Michela Baccini
FFFranco Fusi
Franco Fusi