Hyperthermia is the use of heat to control Varroa destructor. Various apparatuses have been proposed to effectively apply heat and recently the Bee Ethic system was developed in Italy. The Bee Ethic system is a technological hive consisting of a set of heated frames and an electronic control unit. Trials were carried out in the years 2018, 2020 and 2021 to compare colony strength and mite infestation in heat-treated and untreated control bee-hives. In addition, the influence of repeated heat treatments on the development of bee colonies and mite populations was verified by means of a mathematical model. Both in apiary and in silica results show that hyperthermia can be effectively used for V. destructor control within an IPM approach, even in the presence of substantial re-infestation phenomena.