Rutting has been considered the most serious distress in flexible pavements for many years. Flow number is an explanatory index for the evaluation of the rutting potential of asphalt mixtures. In this study, a promising variant of genetic programming, namely, gene expression programming (GEP), is utilized to predict the flow number of dense asphalt-aggregate mixtures. The proposed constitutive models relate the flow number of Marshall specimens to the coarse and fine aggregate contents, percentage of air voids, percentage of voids in mineral aggregate, Marshall stability, and Marshall flow. Different correlations were developed using different combinations of the influencing parameters. The comprehensive experimental database used for the development of the correlations was established on the basis of a series of uniaxial dynamic-creep tests conducted in this study. Relative importance values of various predictor variables were calculated to determine their contributions to the flow number prediction. A m...