The regional economy of desertification area plays a pivotal role in the land economy. Therefore, the rational development of deserticulture is of paramount significance to the economic, social, and ecological benefits of sand areas in western China. In this paper, we constructed a comprehensive evaluation index system for the development of deserticulture and the benefits of desertification land use. The entropy method was used to calculate the weight of each index, which was then used to evaluate the level of development in Ordos City from 2010 to 2017. Additionally, we analyzed the coupling relationship between these two subsystems. The results indicate a gradual increase in the input, output, and environmental evaluation value of deserticulture development, as well as the economic, social, and ecological benefits of desertification land use from 2010 to 2017 in Ordos City. Additionally, there has been an overall improvement in the comprehensive evaluation value of both systems. The level of coupling and coordinated development between deserticulture development and desertification land use benefits has been further enhanced, with a significant increase in the degree of subsystem coordination. Initially, there was serious internal and external developmental discoordination in the system, which gradually improved to an overall state of barely coordinated.